Ma rheumatologists akhoza kusiyana mu folic acid supplementation
Ndizozoloŵera kuti madokotala apereke mankhwala a folic acid pa odwala matenda a nyamakazi omwe amachitidwa ndi methotrexate. Folic acid yatha ndi methotrexate, choncho imayenera kubwereranso kudzera mu supplementation. Folic acid amafunika kuthandizira kuchepa kwa maselo ofiira magazi ndi kuchepa kwa magazi m'thupi. Zakhala zikuwonetseratu kuchepetsa kupwetekedwa mtima kuchokera ku methotrexate.
Methotrexate ndi DMARD yomwe imatchulidwa kawirikawiri (matenda osinthira anti-rheumatic drugs) pa matenda a rhumum ndi nyamakazi zina. Methotrexate imapezeka pakamwa komanso mujambulidwe . Mwanjira iliyonse, methotrexate imaperekedwa kamodzi pa sabata (tsiku lomwelo sabata iliyonse).
Zomwe Zamankhwala Zimanena Ponena za Folic Acid
Pali kusiyana ngati madokotala amapereka mlingo wa 1 milligram imodzi ya folic acid kapena mlingo waukulu pamlungu. Mlingo waukulu umaperekedwa tsiku lotsatira mlingo wa methotrexate. Nthawi zina madokotala amalangiza odwala awo kuti azidutsa mlingo wa tsiku ndi tsiku pa tsiku la mlingo wawo wa methotrexate.
Nyuzipepala ya National Rheumatoid Arthritis Society ku UK, "Methotrexate imatulutsa thupi la folic acid ndipo nthawi zambiri zotsatira zake zimachepetsedwa mwa kutenga mapulogalamu a folic acid. Izi zingatengedwe ngati ma milligrams 5 mpaka 10 mlungu uliwonse. mphamvu ya methotrexate ndipo ambiri a rheumatologists amalimbikitsa kutenga folic acid limodzi kapena masiku awiri pambuyo pa methotrexate, makamaka osatenga tsiku lomwelo monga methotrexate. "
Ndondomeko zosiyana zothandizira ndi folic acid zingayambitse mafunso pa zomwe ziri zolondola. Katswiri wina wa ziphuphu, dzina lake Scott Zashin, pulofesa wothandizira pa yunivesite ya Texas Southwestern Medical School, akuti, "Ndili ndi odwala anga tsiku ndi tsiku, kuphatikizapo tsiku la methotrexate. Ndikuganiza kuti mwina ndibwino kapena kulipukuta tsikulo.
Sizinaphunzirepo, koma nkutheka kuti mwina pulottiyo ndi yovulaza. "
Zotsatira Zokambirana kuchokera ku Cochrane
Mu nyuzipepala yokhudzana ndi ndemanga ya Cochrane yomwe inalembedwa mu Julayi 2013, yomwe inagwirizana ndi umboni wothandizira kugwiritsa ntchito folic acid kuchepetsa zotsatira zoyanjanitsidwa ndi methotrexate, zinanenedwa kuti folic acid amagwiritsidwa ntchito mosiyana-madokotala ena amapereka folic acid kuti azigwiritsidwa ntchito nthawi zonse ndi odwala omwe amatenga methotrexate, pamene madokotala ena amapereka mankhwala kwa odwala omwe ali ndi zotsatira za methotrexate. Enanso samawalamula chifukwa amakhulupirira kuti asidi a folic amachepetsa mphamvu ya methotrexate.
Kuwongolera, kotengera zotsatira za mayesero asanu ndi limodzi omwe amachititsa kuti pakhale ma ARV, kumathandizira kugwiritsa ntchito mankhwala ochepa a folic acid mu odwala matenda a nyamakazi omwe amachizidwa ndi methotrexate. Folic acid supplementation yachepetsa kuchepa kwa ubongo ndi chiwindi cha enzyme kukwera. Nyuzipepalayi inati folic acid 1 milligram tsiku ndi tsiku amagwiritsidwa ntchito kwambiri pophatikizapo odwala mankhwala a methotrexate.
Ndondomeko yowonjezera komanso yotsatira inayambitsanso mafunso ngati odwala ayenera kutenga folic acid miyoyo yawo yonse, komanso ngati mlingo wapamwamba ndi wopindulitsa kapena ukhoza kusokoneza methotrexate.
Zinatsimikiziridwa kuti mgwirizano wa mayendedwewo udzafuna kuphunzira zambiri.
Mfundo Yofunika Kwambiri
Pali mitundu yovomerezeka yambiri yogwiritsira ntchito folic acid pamene akuchiritsidwa ndi methotrexate, ndipo maphunziro ena angasonyeze kuti ndibwino. Kambiranani ndi dokotalayo momveka bwino kuti amvetse chifukwa chake amasankha.
Zotsatira:
> Butler R. Methotrexate mu chifuwa chachikulu cha nyamakazi. National Rheumatoid Arthritis Society. https://www.nras.org.uk/methotrexate-in-rheumatoid-arthritis.
> Singh JA. Folic acid imathandizira odwala nyamakazi omwe amamwa methotrexate: zabwino zimakhala bwino (olemba). Dongosolo la Cochrane la Zosintha Zogwirizana 2013; 7: ED000063. dx.doi.org/10.1002/14651858.ED000063
> Shea B, Swinden MV, Tanjong Ghogomu E, Ortiz Z, Katchamart W, Rader T, et al. Folic acid ndi folinic acid pofuna kuchepetsa zotsatirapo kwa odwala omwe amalandira methotrexate ya nyamakazi ya nyamakazi. Dongosolo la Cochrane la Zosintha Zogwirizana 2013; 5: CD000951. dx.doi.org/10.1002/14651858.CD000951.pub2