Kodi odwala nyamakazi ayenera kudandaula?
Ena odwala nyamakazi a nyamakazi amawopsya ngati atayikidwa methotrexate . Mankhwalawa amadziwika kuti ndi mankhwala a chemotherapy omwe amagwiritsidwa ntchito pochiza khansa. Koma, kodi ndi zolondola kugawa kapena kuganizira methotrexate mankhwala a chemotherapy pamene akulamulidwa ndi nyamakazi ya nyamakazi? Mwina izi zimawoneka ngati funso losafunikira kwa ena, koma ngati maganizo olakwika amachititsa mantha osafunikira kapena amachititsa odwala kugwiritsa ntchito mankhwala omwe angawathandize, funsolo ndilofunika kwambiri.
Tiyeni tione zenizeni.
Yankho Lalifupi
Zaka zoposa 50 zapitazo, methotrexate inayambitsidwa ngati chithandizo cha khansa chifukwa cha zotsatira zake zotsutsana ndi mankhwala. Kwa zaka 25 zapitazi, mankhwalawa akhala akugwiritsidwa ntchito ngati mankhwala osokoneza bongo (DMARD) omwe amachititsa kuti matenda a nyamakazi ndi matenda ena a rheumatic. Methotrexate kwenikweni imatengedwa kuti ndi golide woyenera mankhwala, kapena mankhwala osankhidwa, pochiza matenda a nyamakazi.
Malinga ndi chaputala cha DMARD m'bukuli, Rheumatoid Arthritis: Matenda Oyamba Kwambiri ndi Chithandizo , "Kutchuka kwake kumakhala kosavuta kugwiritsa ntchito (pamlomo kapena pamsewu, mlingo wa mlungu uliwonse), poizoni bwino, mapulogalamu ochizira mofulumira (nthawi zambiri mkati mwa 6 kwa masabata asanu ndi atatu), kupirira, mtengo wotsika mtengo, zopindulitsa zowonjezereka pokhala ndi ma regimens ena a DMARD, ndi kuthekera kwake kuchepetsa kuwonongeka kwa mafilimu. "
Mmene Methotrexate Imagwira Ntchito
Zomwe tazitchula kalezi zikuganiziridwa kuti zikugwirizana ndi kulepheretsa dihydrofolate reductase ndi folic acid kupanga.
Pogwiritsidwa ntchito ngati DMARD, ubwino wa methotrexate umawoneka ngati wokhudzana ndi kudulidwa kwa adenosine, komabe, yemwe ndi wotsutsa wotsutsa-kutupa. Poonjezera zotsatira za methotrexate pa folic acid yopanga, kupatsirana tsiku ndi tsiku ndi folic acid ndi mbali ya kachitidwe ka regimen kwa odwala matenda a rheumatic.
Pogwiritsidwa ntchito ngati mankhwala a chemotherapy, methotrexate imateteza maselo kuti asagwiritse ntchito zojambula kupanga DNA ndi RNA, motero amachepetsa kukula kwa maselo a kansa.
Mlingo Wamtundu Uyenera Kukhala ngati DMARD
Pogwiritsidwa ntchito monga mankhwala a chemo, methotrexate imaperekedwa muzenera mpaka mlingo waukulu. Mlingo umatsimikiziridwa ndi kukula kwa wodwalayo, mtundu wa khansa yothandizidwa, ndi ntchito ya impso. Mlingo waukulu kapena wofanana ndi 500mg / m2 umawoneka wamtali, pamene 50 mpaka 500 mg / m2 ali pakati. Mlingo wochepa umalingaliridwa pansi pa 50 mg / m2.
Pamene methotrexate imagwiritsidwa ntchito pofuna kuchiza nyamakazi, chiwerengerocho chimaonedwa kuti n'chochepa - kawirikawiri chimayamba pa 7.5 mpaka 10 mg / sabata. Ngati nkofunika, mlingowu ukhoza kuwonjezeka mwakuya mpaka 25 mg / sabata.
Ngati zotsatira zake kapena za poizoni zikukula, zimamveka kuti kuchepetsa mlingo kapena kusintha kuchokera pamlomo kupita ku methotrexate kumayambitsa mavuto. Kawirikawiri kuyesedwa kwa magazi kumachitidwa kwa odwala omwe amatha methotrexate (kumaliza magazi, chiwindi ndi mbiri ya impso) kuti azindikire mavuto oyambirira kuti kusintha kungapangidwe. Ngati zosavuta, zovuta zowonongeka zikuchitika, kuthetsa methotrexate kungakhale kotheka.
Mfundo Yofunika Kwambiri
Mukafunsidwa kuti mutsimikizire ngati methotrexate iyenera kuopedwa chifukwa imagwiritsidwa ntchito monga chemotherapy, Scott J.
Zashin, MD (www.scottzashinmd.com/) anayankha kuti, "Ngakhale kuti methotrexate yapamwamba imatha kugwiritsidwa ntchito kwa chemo, rheumatologists amagwiritsa ntchito methotrexate yaing'ono chifukwa chotsutsana ndi zotupa. Kuyanjana pakati pa NSAID (mankhwala ochiritsira matenda a nyamakazi) ndi methotrexate koma sizikumveka kuti ndikulumikizana kwakukulu ndi mlingo wochepa wa mankhwala ogwiritsidwa ntchito pa nyamakazi ya rhumum. Odwala ayenera kukumbukiranso kuti mankhwala akuyenera kuti atengeke kamodzi kamodzi pamlungu kuti athetse zotsatira zake. "
Zotsatira:
Matenda a Nyamakazi: Matenda Oyambirira ndi Chithandizo. Kushi, Weinblatt, ndi Kavanaugh. Kusintha kwachitatu. Mutu 11 - Matenda-Kusintha Mankhwala Osokoneza Bongo.
Kugwiritsa Ntchito Mankhwala ndi Poizoni wa Methotrexate. Ann S. LaCasce, MD. Zaposachedwa. Inayambiranso November 2013.
Methotrexate. American Cancer Society. 12/29/2011.