Mikangano Yoyambitsa Levodopa Zakale Pambuyo Pambuyo pa Matenda a Parkinson
Dopamine ndi mphuno ya ubongo yomwe imadziwika kuchokera ku nkhono ya nigra, yomwe ili m'dera la ubongo lomwe limafota mu matenda a Parkinson . Monga chilengedwe cha dopamine mu ubongo chiyamba kugwa, zizindikiro za matenda a Parkinson zimawonekera. Ngati dopamine imalowetsedwa, zizindikiro zambiri zimakula.
Mmodzi amaganiza kuti dopamine ayenera kuperekedwa mwamsanga.
Pali zina zomwe mungasankhe. Kuwonjezera pa kupatsidwa dopamine mwachindunji (mankhwala otchedwa carbidopa-levodopa), odwala a Parkinson amatha kupindula ndi mankhwala osokoneza bongo omwe amatchedwa dopamine agonists. Izi ndi mankhwala omwe sali a dopamine koma amakhala ofanana pa dongosolo la manjenje. Madokotala ena akhala akutsutsa kuti dopamine agonists ayenera kugwiritsidwa ntchito kale pa matendawa komanso kuti okalamba okha omwe ali ndi chilema choyenera ayenera kulandira levodopa.
Zokambirana za Aleviopopa Oyambirira Gwiritsani ntchito matenda a Parkinson
Levodopa ndi mankhwala ogwiritsidwa ntchito kwambiri pochita zizindikiro za Parkinson. Izo zinati, ziribe zotsatirapo.
Imodzi mwa mantha a levodopa amagwiritsidwa ntchito ndikuti ingayambitse kuthamanga kwambiri kotchedwa dyskinesia . Anthu omwe ali ndi dyskinesia ali ndi kayendetsedwe kake kamene sali m'manja mwawo. Ngakhale kuti zikuwoneka zosasangalatsa, komabe ambiri omwe ali ndi dyskinesia amazisankha kuti parkinsonism, ndipo kafukufuku amasonyeza kuti dyskineia pamapeto pake sichikhudza kwambiri moyo.
Akatswiri ena amanena kuti dopamine ingathe kupititsa patsogolo matendawa poyambitsa zizindikirozo. Kafukufuku wambiri sanavomereze maganizo awa, komabe.
Zizindikiro zimasinthasintha panthawi ya dopamine, kutanthauza kuti pangakhale nthawi yowonjezereka, kusagwedera, ndi kuyenda mofulumira kuposa ena.
Kumbali ina, sikudziwika bwino momwe kusinthaku kumakhudza moyo wa moyo. Komanso, anthu omwe amamwa mankhwala ena monga dopamine agonists amatha kusintha.
Zifukwa zina zothandizira kugwiritsidwa ntchito koyambirira kwa levodopa zimati zidzasintha khalidwe labwino kumayambiriro kwa matendawa, zomwe sizinaperekedwe mosamala. Levodopa ndi yotsika mtengo kwambiri kuposa dopamine agonists.
Makampani a mankhwala osokoneza bongo sakulimbikitsanso kugwiritsa ntchito levodopa chifukwa pali mitundu yambiri yowonjezera. Mwa kuyankhula kwina, pali otsogolera ndalama ku makampani opanga mankhwala kulimbikitsa kugwiritsa ntchito mankhwala ena, okwera mtengo kwambiri kumayambiriro kwa matenda a Parkinson, m'malo modalira pa levodopa yakale, yoyesera ndi yowona, ndipo izi zingakhudze kusankha kwa madokotala.
Zotsutsana ndi Alevi Oyambirira Kugwiritsa ntchito mu Matenda a Parkinson
Ndi ochepa chabe omwe angatsutsane za kupambana kwa mankhwala a levodopa, ndipo odwala onse a Parkinson mwina amafunikira mankhwalawa. Pali zifukwa zina zowonetsera poyambanso pambuyo pazochitika za matenda.
Mankhwala amafunika kutchulidwa pa matenda onse. Mwa kuyankhula kwina, munthu yemwe ali ndi matenda a Parkinson omwe amayamba pa levodopa adzafuna kuti mankhwalawa aziwonjezeka pamene matenda awo akufalikira.
Kawirikawiri, mphamvu ya dopamine idzatha pambuyo pa zaka zitatu. Pamene mlingo waukulu wa levodopa sungathe kulamulira zizindikiro, ndiyanso yowonjezera yowonjezera? Popanda mankhwala olimbitsa mphamvu, opaleshoni ingakhale yokhayo yomaliza. Kodi si bwino kupulumutsa "mfuti yayikulu" pamapeto pake, pamene zizindikiro zowopsa kwambiri?
Kuwonjezera pa zotsatira za levodopa zomwe zatchulidwa kale, palinso mavuto ena omwe angaphatikizepo kuwonjezereka kwa chidziwitso, psychosis, ndi kuchepetsa kuganiza mofulumira. N'zoona kuti mankhwala ena monga dopamine agonists amakhalanso ndi zotsatira, monga kutupa, kusasamala komanso mavuto a maganizo, monga kutchova njuga.
Mwachidule, nchifukwa ninji mungagwiritse ntchito "mfuti" yanu mofulumira, makamaka ngati ochita kafukufuku wakale (ngakhale atakhala otsutsana) adanena kuti zikhoza kuwonjezera matendawa? Makamaka pamene mungagwiritse ntchito mankhwala ovuta omwe angachepetsere matendawa, kuphatikizapo kuthandizira zizindikiro?
Kodi Pali Njira Zina Zothandizira Matenda a Parkinson?
Njira ina ingakhale kuyamba kuyamba mankhwala monga monoamine oxidase inhibitor. Chitsanzo ndi rasagiline, chomwe chikuwoneka kukhala chothandiza kwambiri mutayambika mofulumira. Kafukufuku wina wanena kuti rasagiline ikhoza kuchepetsa kuwonongeka kwa ubongo kuphatikizapo kulamulira zizindikiro, zomwe maphunzirowa ndizovuta kwambiri. Izi ndi zosiyana ndi dopamine, momwe maphunziro ena oyambirira adayambitsira matenda kuwonjezereka ndi mankhwala.
Kuthetsa Kusamvana:
Kodi mfundo ziwirizi zingagwirizanitsidwe bwanji? Pamapeto pake, palibe mankhwala omwe amathandiza aliyense. Anthu ndi osiyana ndipo akusowa mankhwala ovomerezeka payekha. Njira imodzi yomwe mungathe kuyambira ndiyo kuyamba ndi mankhwala monga rasagiline, ndikutsatiridwa ndi mlingo wa levodopa. Pamene nthendayi ikupita, dopamine agonist ikhoza kuwonjezeredwa, motsogozedwa ndi mlingo waukulu wa levodopa. Komabe, pomaliza, njira yabwino kwambiri idzakhala yosiyana malinga ndi zosowa za wodwala komanso zomwe adokotala amakonda pazosiyana ndi mankhwala.
Zotsatira:
Marras C, Lang A, Krahn M, Tomlinson G, Naglie G; Parkinson Study Group. Kukhala ndi moyo mu matenda oyambirira a Parkinson: zotsatira za dyskinesias ndi kusintha kwa magalimoto. Mov Disord. 2004 Jan; 19 (1): 22-8.
Parkkinen L, O'Sullivan SS, Kuoppamäki M, Collins C, Kallis C, Holton JL, Williams DR, Revesz T, Lees AJ. Kodi levodopa imathandizira kudwala matenda a Parkinson matenda? Neurology. 2011 Oct 11; 77 (15): 1420-6.
Vlaar A, Crovestadt A, Van Laar T, Bloem BR.Kulandira matenda a Parkinson oyambirira: levodopa kukonzanso. Pract Neurol. 2011 Jun; 11 (3): 145-52.