Matenda a Parkinson amapezeka pamene maselo ena a mitsempha (omwe amatchedwa neurons) omwe ali mu gawo lina la ubongo amasiya kugwira ntchito bwino kapena kufa. Ma neuroniwa nthawi zambiri amabweretsa mankhwala ofunika kwambiri omwe amatchedwa dopamine, omwe amathandiza kuchepetsa minofu.
Ngati mulibe dopamine okwanira chifukwa ma neuroni awa sakuwulutsa, simungathe kutsogolera kapena kuteteza kusuntha kwanu kawirikawiri.
Ndichifukwa chakuti dera lanu la ubongo lomwe limakhala ndi neuroni (dera la ubongo lotchedwa substantia nigra) silingatumize zizindikiro kumalo otsatira omwe amatchedwa "relay station" ya ubongo, corpus striatum.
Kafukufuku wasonyeza kuti odwala a Parkinson akusowa maselo 80% kapena oposerapo a dopamine mu nigra. Kulephera kwa dopamine kumabweretsa zovuta zowuma, zomwe zimapezeka mu matenda a Parkinson.
Nchiyani Chimachititsa Kuwonongeka kwa Dopamine ku Parkinson?
Asayansi sakudziwa chifukwa chake maselo a ubongo mumbali ya ubra ya ubra amasiya kupanga dopamine, koma pali ziphunzitso zambiri.
Genetics ikhoza kugwira nawo ntchito zina za matenda a Parkinson. Pafupifupi 15% mpaka 25% mwa omwe amapezeka ndi Parkinson ali ndi wachibale amene ali ndi vutoli, kusonyeza kuti akhoza kugwirizana. Kuwonjezera apo, pali mitundu yina ya matenda a Parkinson omwe amathamangira m'mabanja, ndipo zina mwa majeremusi okhudzana ndi matendawa apezeka.
Koma anthu ambiri omwe ali ndi matenda a Parkinson sakuwoneka kuti ali ndi mbiri yolimba ya banja, ndipo kotero akatswiri akuyang'ana kwina chifukwa cha vutoli.
Mfundo Zomwe Zimayambira Muzu
Chiphunzitso chimodzi chokhudza chiyambi cha matenda a Parkinson - chiwonongeko cha maselo a mitsempha omwe amachititsa kuti dopamine - agwire kuti maselo awonongeke chifukwa cha zowonongeka m'thupi.
Zosintha zamadzimadzi zimakhala zosasunthika, zomwe zingathe kuwononga mamolekyu omwe amapangidwa ndi machitidwe oyenera a thupi.
Anthu ochita masewera olimbitsa thupi amayankha ndi makompyuta oyandikana nawo (makamaka zitsulo monga chitsulo) mu njira yotchedwa okosijeni. Kutsekemera kumaganiziridwa kuti kukhoza kuwononga zinyama, kuphatikizapo neurons. Kawirikawiri, kuwonongeka kwakukulu kwaulere kumayang'aniridwa ndi antioxidants, mankhwala omwe amateteza maselo kuwonongeka uku.
Odwala omwe ali ndi matenda a Parkinson apezeka kuti ayamba kuchuluka kwa ubongo, makamaka mu nigra, ndi kuchepa kwa ferritin, mapuloteni omwe amapezeka mu thupi lomwe limakhala ndi chitsulo ndikulipatula, motero amateteza matupi a mthupi.
Mfundo ina imaphatikizapo mankhwala ophera tizilombo ndi poizoni wina. Asayansi ena amanena kuti matenda a Parkinson akhoza kuchitika pamene poizoni m'deralo amawononga mitsempha yomwe imapanga dopamine. Pali mitundu yambiri ya poizoni (1-methyl-4-phenyl-1,2,3,6, -tetrahydropyridine, kapena MPTP, ndi imodzi) yomwe ingayambitse matenda a Parkinson.
Pakalipano, palibe kafukufuku amene wapereka umboni wotsimikizira kuti poizoni ndi amene amachititsa matenda.
Koma nthano ina imanena kuti matenda a Parkinson amapezeka pamene, chifukwa cha zifukwa zosadziwika, zachibadwa, zokhudzana ndi zaka zowonjezera za dopamine zimathamanga mwa anthu ena.
Chiphunzitso ichi chimatsimikiziridwa ndi lingaliro lakuti ife timataya pang'ono pang'onopang'ono njira zomwe zimatetezera mitsempha yathu pamene ife tikulamba.
Ofufuza ambiri amakhulupirira kuti njira zinayi izi: - kuwonongeka kwa oxidative , poizoni, chilengedwe, komanso kukalamba - zikhoza kusonyeza kuti zimayambitsa matendawa.
Zotsatira:
Matenda a Parkinson Foundation. Zimayambitsa zowonjezera.
Matenda a Parkinson Foundation. Zochitika Zakachisi ndi Parkinson: Kodi Taphunzira Chiyani? pepala lolemba.