Udindo wa ma Genetics siwudziwika bwino kwa mabanja ogwidwa
Mankhwala amtunduwu amawathandiza kwambiri m'magulu onse a matenda a Parkinson . Komabe, ngakhale kukhala ndi mitundu yosiyanasiyana ya majeremusi kungapangitse chiopsezo chanu cha matendawa, sizikutanthauza kuti mudzachipeza.
Pafupifupi 15 mpaka 25 peresenti ya anthu omwe amakhala ndi Parkinson ali ndi mbiri ya banja, kaya ndi wachibale kapena wachiwiri.
Kukhala ndi amodzi kapena ambiri mwa achibalewa kukupangitsani kukhala pangozi yochepa ya Parkinson, koma sichikutitsimikizirani kuti mudzakula matendawa.
Mosiyana ndi zimenezo, ngati muli ndi Parkinson, siziyenera kutanthauza kuti mwana wanu aliyense kapena zidzukulu zake adzalandira matendawo. Zimangowonetsa kuti chiwopsezo chawo chili pamwamba pa omwe alibe mbiri ya banja.
Pamapeto pake, malo ambiri a Parkinson alibe chifukwa chodziwikiratu (chomwe timatcha kuti kukhala ndi matenda opatsirana pogonana kapena odwala). Ngakhale pali maonekedwe omwe amawoneka akuyenda m'mabanja, izi ndizochepa peresenti ya milandu - pafupifupi 5 mpaka 10 peresenti, zonse zanenedwa.
Kusinthika kwa Gene Key Associated With Parkinson's
Pali mitundu ina ya Parkinson yomwe imawoneka kuti imakhudzidwa ndi zilema zomwe zimayambitsa mabanja. Timakonda kuona izi ndi machitidwe oyambirira a matendawa omwe zizindikiro zikuwonekera kale kwambiri kusiyana ndi msinkhu wa zaka 60 .
Mtundu umodzi wa kusintha kwa majini ophatikizapo mtundu wa parkinsonism mumtundu umene umatchedwa SNCA . Izi ndizimene zimaphatikizapo kupanga alpha-synuclein protein, biomolecule yomwe ingapangitse kuti zikhale zosavuta mu maselo a mitsempha. Ngakhale kuti ndi osowa pakati pa anthu ambiri, SNCA gene mutation yadziwika m'madera awiri mwa mabanja 100 aliwonse omwe akhudzidwa ndi Parkinson.
Mu 2004, asayansi anapeza chikhalidwe chosinthika chamtunduwu m'mabanja angapo omwe anthu ambiri adakhudzidwa nawo. Zomwe zimatchedwa kusintha kwa LRRK2 lero zimagwirizanitsidwa ndi pafupifupi magawo awiri mpaka awiri pa milandu yonse ya Parkinson, makamaka yomwe imakhudza anthu a Chiyuda, Ashkenazi, North African Arab Berber, kapena Basque.
Kusintha kwina kwa GBA gene kumadziwika kale chifukwa cha matenda a Gaucher (matenda obadwa nawo omwe amadziwika ndi kuvulaza, kutopa, kuchepa kwa magazi, ndi kukulitsa chiwindi ndi nthenda). Kafukufuku kuyambira pano wasonyeza kuti kusintha kwa GBA kulipo mwa anthu ambiri omwe ali ndi Parkinson, akusonyeza kuti pali kusiyana pakati pa kusintha kwa matenda ndi matenda.
Genetics ndi Zinthu Zachilengedwe
Zinthu zachilengedwe zimathandizanso kuti pakhale chitukuko cha Parkinson ndipo nthawi zina zimagwira ntchito limodzi ndi majeremusi chifukwa cha matendawa . Kafukufuku wina mu 2004 anasonyeza kuti anthu omwe anasintha chibadwa cha CYP2D6 ndipo anadziwidwa ndi mankhwala ophera tizilombo anali otheka kawiri kuti akhale ndi Parkinson.
Kwaokha, mankhwala ophera tizilombo, zitsulo, zotukira, ndi zina zoledzeretsa zonse zimagwirizana ndi Parkinson. Koma chochititsa chidwi ndi chakuti iwo omwe anali ndi kusintha kwa CYB2D6 ndipo sanadziwidwe ndi mankhwala ophera tizilombo sankapezeka kuti ali pachiopsezo chachikulu chokhazikitsa vutoli.
Mawu Ochokera
Ngakhale kuti sipangakhale phindu lenileni kwa inu pakali pano, zotsatira za kuyesedwa kwa majeremusi zingathandizire kafukufuku wina wa Parkinson mwa kulola asayansi kumvetsa bwino matendawa ndi kukhazikitsa mankhwala atsopano. Ngakhale chisankho choyesera ndi chaumwini, zingakhale zopindulitsa ngati mamembala ambiri a m'banja akhudzidwa kapena ngati muli pachiopsezo chachikulu chochokera ku mtundu wanu.
Zotsatira:
> Lesage, S. ndi Brice, A. "Matenda a Parkinson: kuchokera ku maonekedwe amodzi kupita ku zifukwa za chibadwa.". Human Molecular Genetics . 2009; 18 (R1): R48-59.
> Stewart, A .; Mfundo, D .; William J. et al. Matenda a Parkinson: Kugwiritsira Ntchito Mankhwala ndi Kachilombo ka HIV . New York: Demos Publishing Medical; 2008; ISBN-10: 1933864001.