Mankhwala atsopano a polima amathandiza kuti chikopa cha khungu chikhale bwino
Zonse zopangidwa mwatsopano kapena zochitika mwanjira ina zimapangitsa kuti ziyambike ku ntchito ya ena. Mankhwala atsopano komanso mankhwala atsopano ndi osiyana. Ngati mukukhoza kusintha pa mapangidwe a asayansi wina, ndipo kupita patsogolo kwanu kuli kosavuta, kosavuta komanso kosavuta, mwina mukupita ku chinachake.
Posachedwa, zambiri zazing'ono zakhala zikuzungulira nkhani zatsopano za khungu la ibuprofen lomwe likukonzedwa ndi akatswiri a pa yunivesite ya Warwick ndi kampani yawo yaing'ono Medherant.
Mwachiwonekere, izi zimakhala zowonjezera, zosasokonezeka komanso zimapereka mankhwala mosiyana kwambiri ndi chirichonse chimene ife tiri nachobe kuti tikhale ndi matupi athu.
Kodi Ibuprofen Ndi Chiyani?
Ibuprofen (taganizani Advil kapena Motrin) ndi NSAID (mankhwala osakanikirana ndi mankhwala osakanizidwa) omwe amaletsa mowa mankhwala a cyclooxygenase-1 (COX-1) ndi michere ya cyclooxygenase-2 (COX-2) yomwe imalepheretsa kupanga prostaglandin. Pogwiritsa ntchito prostaglandin kaphatikizidwe, ibuprofen imathandiza kuchepetsa ululu, kutupa ndi malungo. Zindikirani, zina za NSAID zimaphatikizapo aspirin ndi naproxen.
Akatswiri amaganiza kuti kuwonjezera pa kusokoneza prostaglandin kupanga, ibuprofen akhoza kuthana ndi kutupa mwa kukhudza magazi mwa njira zina, kuphatikizapo kusinthika kwa mankhwala a lymphocyte, kulepheretsa chemotaxis, kulepheretsa a neutrophil aggregation kapena activation, ndi kuchepa kwa proinflammatory maginito cytokine.
Kodi Ibuprofen Amagwiritsidwa Ntchito Chiyani?
Ibuprofen amagwiritsidwa ntchito kuchepetsa kutentha kwa thupi komanso kuthana ndi zowawa zosiyanasiyana, monga zomwe zimayambitsa kupweteka kumutu, kupweteka kumbuyo, nyamakazi, mano ndi msambo.
Chochititsa chidwi, NSAIDs monga ibuprofen ndi zabwino kwambiri pochiza ululu wa miyala ya impso. Komanso, ibuprofen ikhoza kuphatikizidwa ndi opioid (monga hydrocodone) kuti muzitha kupweteka kwambiri.
Kodi Ibuprofen Amalamuliridwa Bwanji?
Njira zosiyanasiyana zolamulira zilipo kwa ibuprofen, kuphatikizapo mapiritsi, jekeseni, ndi gels.
Ulamuliro wa ibuprofen kudzera patch ndi wolemba komanso wabwino kuposa mapulogalamu ogwiritsa ntchito gels. Magulu a Ibuprofen ndi osokoneza ndipo samapereka mankhwala nthawi zonse.
Nazi zina zomwe zimapindula phindu la ibuprofen ndi teknoloji yapamwamba yake ya polymer:
- Teknoloji yatsopano imalola kuti chigambacho chizikhala ndi mankhwala oposa asanu kapena khumi. Mwa kuyankhula kwina, 30 peresenti ya kulemera kwa chigamba ndi mankhwala enieni.
- Kutulutsidwa kwa mankhwala m'thupi kumakhala kolimba ndipo kungathe kugwira ntchito maola 12. Pakalipano, anthu omwe ali ndi mlingo waukulu wa ibuprofen angafunike kumwa mapiritsi maola anayi onse.
- Chigambachi n'chokwanira kwambiri, chosasinthasintha, chophweka komanso chosasuntha kusiyana ndi zina. Komanso, chigambacho chimasiya zocheperapo ndipo ndizochepa komanso zosaoneka bwino.
Chipangizo cha ibuprofen chinapangidwa pogwiritsa ntchito makina opangidwa ndi mapulogalamu atsopano opangidwe ndi kampani yotchedwa Bostik ndipo imaloledwa kuti agwiritsidwe ntchito ndi Medherant.
Mapulogalamu Othandizira Patch Yatsopano Angakhale Masewera-Kusintha
Malinga ndi Medherant, zambiri zomwe zimapweteketsa zopweteka zomwe zilipo pakalipano zilibe mankhwala a painkiller ndipo amatulutsa kutentha (think menthol). Momwemonso, zida zakale izi ndizochepa muzogwiritsira ntchito. Pulogalamu yatsopano ya ibuprofen ya Medherant ndizopanga m'njira zambiri.
Choyamba chifukwa chigambacho ndi chosaoneka, chochita nthawi yaitali komanso chosavuta kugwiritsa ntchito, chikhoza kuthandiza makamaka anthu ena odwala monga othamanga ndi anthu omwe ali ndi vuto lakumatira mankhwala . Mwachitsanzo, wothamanga angagwiritse ntchito chigamulo ku malo ovuta kapena kupuma kwa maola ambiri, kapena munthu amene akumwa mankhwala ambiri akhoza kukhala ndi mapiritsi ochepa kuti azidandaula.
Chachiwiri, poyendetsa mimba ndi kumasula mankhwala molunjika pakhungu, kagawo ka ibuprofen sikanapangitsa kuti mimba isakhumudwitse, zomwe zimakhala zovuta kwambiri kwa iwo omwe ali ndi miyezo yapamwamba ya NSAID.
Chachitatu, zipangizo zamakono zomwe zimagwiritsidwa ntchito popanga chigambachi zingasankhidwe kupereka mitundu ina ya mankhwala, monga ibuprofen, yomwe kale inali yosamvetsetseka kuti izi zitheke. Zindikirani, kupweteka kwamtundu wina kumaperekedwanso mu patch mawonekedwe monga fentanyl (opioid) ndi lidocaine (mankhwala opweteka kwambiri), ndipo zingakhale zosangalatsa kuona ngati kachilomboka kameneka kakuyambitsanso mankhwalawa.
Kodi Ibuprofen Ali ndi Mavuto Oipa?
Ibuprofen amagulitsidwa pa kompyutayo ndipo chiopsezo cha zotsatira zake ndizochepa. Kupsya mtima kwa m'mimba ndi zotsatira zowopsya kwambiri za NSAID monga ibuprofen. Zotsatira zina zoipa za ibuprofen zikuphatikizapo magazi (monga ubongo wamagazi kapena stroke) ndi ululu wa zilonda.
Onani nkhaniyi yokhudzana ndi momwe ma NSAID amathandizira ku mayeso osakwanira ana.
Monga tafotokozera kale, omwe amapanga kachilombo ka ibuprofen atsopano amanena kuti ndi chiwopsezo chawo, palibe chiopsezo chakumva chifukwa chakuti mankhwalawa amachotsedwa ndi khungu osati m'matumbo.
Komabe kawirikawiri, ibuprofen ikhoza kuyambitsa mitsempha yambiri, ming'oma ndi zina zomwe zimakhudza khungu. Anthu omwe ali ndi mbiri ya atopy , kapena omwe ali "hyperallergic" ndipo amavutika ndi chilengedwe, hay fever ndi asthma, amadwala kwambiri ku ibuprofen. Komabe, anthu opanda chiopsezo adayambitsa zowopsa kwa ibuprofen.
Chigawo cha ibuprofen chiri kutali kwambiri ndi kugunda msika ndipo sichiyenera kukhala chipani cha FDA. Pakalipano, pali kafukufuku wochepa kwambiri pa chigawochi. Zambiri zomwe timadziwa zimachokera ku zofalitsa, zofunsana ndi mauthenga a wailesi-ndipo tidzakhala tikuwona deta yeniyeni tisanamvetse chiganizo chatsopanochi. Mwachitsanzo, sizikudziwika bwino ngati chiwerengero cha ibuprofen chimawonjezereka kwambiri komanso chimawonjezereka mwakung'onoting'ono kake kamene kangapangitse kuti anthu azikhala ndi khungu m'malo mwa NSAID.
Poyembekezera, Medherant, yemwe amapanga chida cha ibuprofen, akuyembekezera kuti buku lake la mankhwala loperekera mankhwala lidzagwiritsidwa ntchito poyambitsa mankhwala ena osokoneza bongo komanso ambiri omwe poyamba sanalipo pa mawonekedwe. Mwachitsanzo, Medherant akuyesera ndi methyl salicylate patch. (Methly salicylate ndizomwe zimagwira ntchito ku BENGAY.)
Zotsatira
Nkhani yotchedwa "hypersensitivity yochedwa-hypersensitivity" imachokera ku ibuprofen "ndi E Nettis ndi olemba anzawo omwe amafalitsidwa mu zowopsa m'chaka cha 2003.
Kulembera kotchedwa "Ibuprofen" kuchokera ku Drug Monographs gawo la Access Medicine.