Pamene anthu amaganiza za matenda a Parkinson , zizindikiro zoyamba zomwe zimabwera m'maganizo zimagwiritsa ntchito zizindikiro monga kupumulira, kuthamanga, kapena kuyenda mofulumira.
Koma zizindikiro zosadziwika , monga mavuto a maganizo ndi kugona, zimakhalanso zachilendo ku Parkinson. Chizindikiro chimodzi chosadziŵika chimene akatswiri akuchiganizira kwambiri ndi kutaya kununkhiza, komwe kumachitika pafupifupi 90 peresenti ya anthu omwe ali ndi matenda a Parkinson oyambirira.
Kuwonongeka kwa fungo (kutchedwa hyposmia kapena kusokoneza mphamvu) sikungowononga moyo wa munthu, koma ndi chimodzi mwa zizindikiro zoyambirira za Parkinson.
Potengera lingaliro limeneli mopitirira apo, akatswiri amakhulupirira kuti ngati fungo la munthu limasokonekera msanga, lingapereke chitsimikizo ku matenda awo a m'magazi-ndipo pakali pano palifukufuku amene wasintha lingaliro ili kukhala chenicheni.
Kafukufuku Wotsutsa Kusuta Kuchepetsa Kulosera Matenda a Parkinson
Mu kafukufuku wa Neurology, mphamvu ya kununkhiza kwa anthu oposa 2500 wathanzi inayesedwa mu 1999-2000. Otsatirawa anali a zaka zapakati pa 75 ndipo onse amakhala m'madera akumidzi a Pittsburgh, Pennsylvania ndi Memphis, Tennessee.
Maganizo awo a kununkhira anafufuzidwa pogwiritsa ntchito Chidziwitso Chachidule Chodziwika (BSIT). Pachiyeso ichi, ophunzira adayamba kuwomba ndikumva fungo losiyana siyana. Kenaka amafunika kudziwa fungo la sinamoni, mandimu, mafuta, sopo, ndi anyezi kuchokera ku mayankho anayi omwe angasankhidwe.
Zida zambiri zopezera deta zinagwiritsidwa ntchito pozindikira anthu omwe adayambitsa matenda a Parkinson kudzera mu August 31st, 2012.
Zotsatira zinawulula kuti pakapita nthawi zaka 9,8 zotsatila, zochitika 42 za matenda a Parkinson zinapezeka, ndipo ndizomwezi, chiyanjano chinapezeka pakati pa kumvetsa bwino kwa fungo komanso kuopsa kwa Parkinson.
Izi zikutanthauza kuti anthu omwe anali ndi umphawi wochuluka kwambiri (kutanthauza kuti anapeza mu tertile yotsika kwambiri ya chiwerengero chonse cha BIST) anali ndi chiopsezo chachikulu chokhalira ndi matenda a Parkinson.
Chochititsa chidwi ndi chakuti, pamene phunziroli linasinthika kukhala mtundu ndi chikhalidwe, chiyanjano chinali champhamvu kwambiri kwa ophunzira a ku Caucasian, poyerekeza ndi anthu a ku Africa-America, ndi amuna, poyerekeza ndi amayi.
Kodi Zotsatira Zimatanthauza Chiyani?
Uthenga wobwerera kunyumba ndi wakuti "kuyesa zofufuzira" kungathe kufotokozera chiopsezo cha munthu chokhala ndi matenda a Parkinson. Icho chinati, pali zikhomo zochepa zomwe muyenera kukumbukira.
Choyamba ndichokuti kutaya kwa fungo kungakhale chifukwa cha mavuto ena azachuma kupatula Parkinson. Matenda ena a ubongo monga Alzheimer angachititse kusokonezeka kwa fungo, monga momwe zingakhalire zosagwirizana ndi ubongo monga rhinosinusitis . Ichi ndichifukwa chake kulingalira fungo la fungo lomwe liri loyenera kwa PD ndilofunikira, ndipo ofufuza sanayambepo zonsezi.
Chachiwiri, "kununkhiza mayesero" ayenera kuyesa kusokoneza kwabwino kwa fungo. Kungonena kuti munthu ali ndi kutaya kununkhiza sikumveka. Mwina munthu wina amavutika kusankha pakati pa zofukiza pamene wina sangathe kuzindikira zofukiza. Kapena munthu akhoza kukhala ndi malo apamwamba kuti azindikire fungo.
Ndipotu kafukufuku akusonyeza kuti ku Parkinson, kuli kovuta kufotokozera fungo, osati kununkhira, kutanthauza kuti akhoza "kununkhiza," koma osati kunena chomwe chiri.
Chomaliza, ndizofunikira kukumbukira kuti mgwirizano kapena mgwirizano ndi kugwirizana chabe kapena kupeza kuchokera pa ziwerengero-si 100% predictive wa munthu aliyense. Mwa kuyankhula kwina, munthu akhoza kutaya kununkhiza kwawo ndi kusayambitsa matenda a Parkinson. Mofananamo, palinso anthu omwe ali ndi matenda a Parkinson omwe amasunga fungo lawo.
Chifukwa cha Kutaya kwa Fungo mu Matenda a Parkinson
Sindikudziwitsanso chifukwa chake kusagwirizana kumeneku kumachitika mu matenda a Parkinson.
Akatswiri apeza kuti kununkhira kuwonongeka kwa thupi limodzi ndi nthenda yochepa ya maselo a cholinergic (maselo a mitsempha omwe amamasula ubongo, acetylcholine) m'kati mwa Meynart-dera la ubongo lomwe limapanga khungu lapamwamba lomwe mumakhala nalo fungo.
Ndidziwe izi, fungo loyang'ana pa kuchepetsa kutaya kwa cholinergic kungakhale koyenera. Ndiyambe kumayambiriro kuti ndiuze, komabe kufufuza kwakukulu kuyenera kuchitidwa.
Kuwonjezera apo, ofufuza ena amanena kuti matenda a Parkinson angayambike m'thupi ndi mababu (malo am'bongo omwe amachititsa kuti kununkhiza kumveke), osati kugawidwa kwa nigra (pomwe pamapeto pake kumatsogolera ku dopamine-producing blood cell imfa). Izi zikhoza kukhala chifukwa chake zizindikiro zoyambirira, monga kuvomereza ndi kutaya kununkhiza, kuyamba zaka zisanayambe kuyendetsa galimoto monga zizindikiro zotsitsimula ndi kuuma kwa minofu.
Mawu Ochokera
Posakhalitsa asayansi amapanga fungo loyesa kufufuza kuti (kapena ngakhale kuganizira ) matenda a Parkinson sakudziwika bwino. Koma, chidwi ichi pa kutayika kwa fungo chingayambitse madokotala kuti aganizire Parkinson pamene odwala awo akubweretsa. Kuyika mosiyana, kungateteze chizindikiro ichi kuti chisamanyalanyazedwe, chomwe chimakhalapo.
Mwina mtsogolo muno, asayansi amatha kuimitsa matenda a Parkinson muzitsulo zake, pamene zimangoyambira mu babuyi musanafike ku nigra.
> Zotsatira:
> Bohnen NI, Albin RL. Matenda a cholinergic ndi matenda a parkinson. Behav Ubongo Res. 2011 Aug 10; 221 (2): 564-73.
> Bowman GL. Zida zowonongeka koyamba kwa Parkinson matenda: Nkhope ya kusagwirizana ndi zosavuta kuzigwira. Neurology . 2017 Oct 3; 89 (14): 1432-34. lembani: 10.1212 / WNL.0000000000004383.
> Chen H et al. Matenda a Parkinson omwe amakhudzidwa ndi anthu akuluakulu ndi achikuda a US. Neurology. 2017 Oct 3; 89 (14): 1441-47. lembani: 10.1212 / WNL.0000000000004382.
> Doty RL. Zovuta zogwira ntchito mu Parkinson matenda. Nat Rev Neurol . 2012 May 15; 8 (6): 329-39.
> Michael J. Fox Foundation. Kwa Research Parkinson. Kutaya Kutayika ndi Matenda a Parkinson.