Ndiyambe kumayambiriro kuti ndiuze, koma mankhwala othandiza angakhale pamapeto
Kafukufuku wina wa ku Canada wofalitsidwa ku New England Journal of Medicine akuti anthu omwe ali ndi matenda odwala matenda osiyanasiyana omwe amagwiritsidwa ntchito ndi matenda a multiple sclerosis (omwe amatchedwa CIS) omwe amatenga mankhwala ophera antibiotic minocycline angakhale ndi chiopsezo chochepa chokhala ndi multiple sclerosis.
Ndithudi, pali chithandizo chachikulu chotenga minocycline ngati mankhwala a CIS, chifukwa ndi otchipa, zosavuta kutenga (ndi mankhwala amlomo), ndipo ali ndi mbiri yabwino yotetezeka.
Komabe, zimakhala bwanji zosiyana ndi mankhwala ena othandizira matenda monga Betaseron kapena Avonex? Kuonjezerapo, phunziroli likusonyeza kuti luso lake ndi laling'ono, ndipo mayesero akuluakulu amafunikira kuti azindikire phindu lake.
Tiyeni tiwone bwinobwino za mankhwala omwe angatulukirepo. Ngakhale izo zikhoza kapena sizikugwira ntchito, kumvetsa "chifukwa" kumbuyo kwa momwe antibiotic ingakhoze kulepheretsa kuti chitukuko cha MS chikhale chokondweretsa payekha.
Minocycline monga Chithandizo Chothetsera CIS
Musanayambe kuphunzira pa minocycline ngati mankhwala a CIS, nkofunika kumvetsetsa kuti matenda omwe ali m'chipatala ndi otani, ndi momwe minocycline ingathenso kulingalira ngati njira yothandizira.
Kodi Kachilombo ka HIV Ndi Chiyani?
Matenda omwe amadzipatula okhaokha ku multiple sclerosis, kapena CIS, amatanthauza anthu omwe ali ndi zizindikiro za "MS-ngati" kwa maola oposa 24, ndipo zizindikirozi zimatha kapena sizigwirizana ndi zilonda zomwe zimawoneka pa MRI.
Wotsatsa ndilo kupatula gawo ili loyambirira, palibe zizindikiro zina zomwe munthu anali nazo kale kale MS , kaya ndi mbiri yawo kapena MRI yawo (palibe zochitika zina za ubongo zokhudzana ndi MS).
Mwa kuyankhula kwina, munthu sangokhala ndi umboni wokhudzana ndi kuchipatala kapena ma radiographic kuti adziwe kuti ali ndi MS.
Chinthu chinanso chimene chimakhalapo ndi matenda a CIS ndi chakuti dokotala ayenera kutsimikizira kuti zizindikiro za "MS-ngati" za munthu (mwachitsanzo, optic neuritis ) ndizo chifukwa cha kutaya kwa myelin-kuteteza maselo a mitsempha mu ubongo ndi msana.
Izi zingafunike kuyesedwa kofanana ngati kutaya magazi kapena kutayika , komanso kuwonetsa zinthu zina zomwe zimatsanzira MS monga matenda kapena matenda ena omwe amachititsa kuti thupi liziyenda bwino (mwachitsanzo, systemic lupus erythematosus).
Apa ndi pamene zinthu zimakhala zovuta, monga momwe katswiri wa zamaganizo amagwiritsira ntchito chiweruzo chake kuti aone ngati munthu yemwe ali ndi matenda okhudzana ndi matenda odwala matendawa akuyenera kuchipatala ndi mankhwala othandizira matenda.
Kawirikawiri, mankhwala akulimbikitsidwa ngati munthu yemwe ali ndi CIS ali ndi MRI yomwe imasonyeza zilonda zomwe zimapezeka mu MS.
Kodi Minocycline N'chiyani?
Minocycline ndi antibiotic, kotero ndi mankhwala omwe amaletsa kukula kwa mabakiteriya. Amagwiritsidwa ntchito pochiza matenda ambiri monga acne, kapena mapapo, mawere, ndi matenda.
Mungadabwe kuti kutenga minocycline kungapindulitse munthu amene ali pachiopsezo chokhala ndi MS. Akatswiri a sayansi apeza minocycline kukhala ndi zotsutsana ndi zotupa, kotero zikhoza kuchepetsa chitetezo cha munthu, kuphatikizapo kuteteza kufalikira kwa mabakiteriya.
N'zotheka kuti malo odana ndi zotupa a minocycline amachokera ku mphamvu yake yosinthira mabakiteriya m'matumbo a munthu popeza mabakiteriyawa amathandiza kwambiri pakulamulira chitetezo cha munthu.
Minocycline amakhulupirira kuti amateteza kusamuka kwa maselo ena a chitetezo cha mthupi omwe amaukira myelin mu ubongo ndi msana.
Potsiriza, kufufuza kumasonyeza kuti minocycline ikhoza kuteteza maselo a mitsempha mwa kulepheretsa imfa yawo. Iyi ndi njira ina yomwe ingathandizire anthu omwe ali ndi CIS.
Kodi Phunziroli Linasonyeza Chiyani?
Kwa zaka 4, anthu 142 omwe ali ndi CIS ochokera kuzipatala 12 zosiyana siyana za ku Canada adapatsidwa mwayi wokalandira 100mg ya minocycline kawiri pa tsiku kapena placebo.
Onsewa adakumana ndi zizindikiro zawo zoyamba zokhudzana ndi CIS m'masiku 180 asanayambe phunzirolo. Ambiri mwa anthuwa anali amayi (68 peresenti), ndipo izi ndizo za CIS (ndizofala kwambiri kwa akazi), ndi zaka zapakati pa zaka 36.
Phunziroli linali lopanda makutu awiri, kutanthauza kuti iwo sanali ophunzira kapena ofufuzawo ankadziwa ngati akulandira minocycline kapena placebo.
Ophunzirawo adayamba kumwa mankhwala (kapena placebo) mpaka atapezeka kuti ali ndi MS kapena mpaka miyezi 24 atangoyamba kumwa minocycline (kapena placebo).
Zotsatira zinasonyeza kuti pasanathe miyezi isanu ndi umodzi ophunzirawo atenga minocycline, 33 peresenti inayamba MS, poyerekeza ndi 61 peresenti ya anthu omwe amatenga malowo. Ichi ndi kusiyana kwa magawo pafupifupi 28 peresenti.
Pambuyo pokonzanso chiwerengero cha zilonda zam'mimba za MS, kusiyana kwake kunatsikira pa 18.5 peresenti, yomwe idakali yovuta. Chifukwa cha kusintha kumeneku ndikuti njira yothetsera MS inakonzedwa panthawi yophunzira. Malinga ndi ndondomeko ya McDonald ya 2010, munthu akhoza kupezeka ndi MS ngati ali ndi umboni wa MS wa matenda a ubongo, ngakhale alibe zizindikiro zokhudzana ndi zilondazo.
Ngakhale kuti chiopsezo chotembenuka ku CIS kupita ku MS chinali chochepa kwambiri mwa iwo omwe anatenga minocycline miyezi 6 poyerekezera ndi placebo, mwatsoka, izi sizinasungidwe pa miyezi 24.
Kodi Minocycline Yifanizitsa Bwanji ndi Zochiritsira Zina za CIS?
Zotsatira za phunziroli zikufanana ndi mankhwala ena ogwiritsidwa ntchito a CIS monga Betaseron (interferon beta-1b), Avonex (interferon beta-1a), ndi Aubagio (teriflunomide), kutanthauza pa miyezi isanu ndi umodzi, mankhwalawa onse akuwonetsa zoopsa zofanana pakukula MS.
Komabe, palibe mutu woti uyambe kuyesa kuyesa minocycline ku umodzi wa mankhwala omwe ali pamwambawa, choncho akadakali koyambirira kuti afotokoze momwe akufaniziradi.
Zonsezi, pamene minocycline imakhala yosangalatsa ngati mankhwala otsika komanso mankhwala otetezeka, kufufuza kuyesa kupindula kwake ngati mankhwala a CIS kunali kochepa ndipo kunali ndi zochepa zina zokhudzana ndi kuphunzira.
Maphunziro akuluakulu akufunikanso kuona kuti izi ndizofunikira kwambiri komanso zothandiza.
Kodi Pali Minocycline Yodalirika?
Mwinamwake mukudzifunsa ngati pali vuto lalikulu kuti mutenge minocycline, ngati ngati mulibe chitetezo kapena ayi. Izi ndizofunika chifukwa kutsatira ma ARV tsiku ndi tsiku kungakhale kovuta, ndipo ngati kukupangitsani kumva bwino, kumamatira kumakhala kovuta kwambiri.
Zotsatira zomwe zimachitika ndi minocycline zikuphatikizapo:
- Kutsekula m'mimba
- Chizungulire kapena kumutu
- Mutu
- Kutsekemera kwa mano (monga kukukuta kwa mano ndi pakamwa)
- Kutengeka kwa dzuwa (iwe ukhoza kukhala woipitsitsa kusiyana ndi kutentha kwa dzuwa nthawizonse)
- Matenda a fungal (mwachitsanzo, matenda a yisiti)
Palinso zovuta koma zovuta zomwe zingachitike ndi minocycline ngati pseudotumor cerebri . Kuonjezerapo, minocycline imatsutsana ndi mimba ndi kuyamwitsa, ndipo zingachepetse kupambana kwa mapiritsi oletsa kubereka.
Komabe, ngakhale mavutowa atchulidwa, minocycline ili ndi mbiri yabwino ya chitetezo ndipo anthu amakonda kuchita bwino.
Inde, monga mankhwala aliwonse, muyenera kuyankhula mwatcheru ndi dokotala za kuopsa kokatenga minocycline motsutsana ndi ubwino wake (ngati mwavomerezedwa kuti mugwiritse ntchito ku CIS), komanso kuwonanso zotsatira zake zonse.
Mawu Ochokera
Ngakhale kuti zotsatira za phunziroli ndi zosangalatsa, ndi chabe njira yachinyamata yomwe ikuwombera MS kuti isapite kwa anthu omwe amapezeka ndi zizindikiro zoyambirira. Mafukufuku ambiri amafunikira pa minocycline, makamaka momwe kafukufuku akadali wosakanikirana ndi zotsatira.
Mwachitsanzo, kafukufuku wina adawonetsa kuti minocycline yoperekedwa ndi Beta-Seron sizinathandize kuti anthu adwale matenda odwala matendawa. Kafukufuku wosatsutsikawa akungotanthauza kuti kufufuza kwina kuyenera kuchitidwa asanamwalire asanatengere odwala awo mankhwala a anti-tetracycline.
> Zotsatira:
> Marcus JF, Waubant EL. Zosinthidwa pa matenda omwe ali m'chipatala komanso njira zochizira matenda osiyanasiyana. Neurohospitalist . 2013 Apr; 3 (2): 65-80.
> Metz LM et al. Chiyeso cha minocycline mu matenda omwe ali ndi matenda osiyanasiyana a multiple sclerosis. N Eng J Med. 2017 Jun 1; 376 (22): 2122-33.
> Multiple Sclerosis Society ya Canada. (May 2017). Minocycline kwa Clinically Isolated Syndrome (CIS) FAQ.
> Sørensen PS ndi al. Minocycline yawonjezera pa intercuton β-1a mu multiple sclerosis: yophunzira randomised RECYCLINE yophunzira. Eur J Neurol. 2016 May; 23 (5): 861-70.