Mankhwala otchedwa mirogabalin akupereka chiyembekezo cha kupumula kwa zizindikiro popanda zotsatira zochepa kusiyana ndi mankhwala opatsirana a fibromyalgia (FMS) . Ndizoyambirira kwambiri kuti mudziwe zenizeni, komabe.
Mirogabalin ndi mankhwala osayesa omwe ali membala wachitatu wa "banja" la mankhwala omwe amadziwika ndi gulu la FMS. Otsatira ake ndi Neurontin (gabapentin) ndi Lyrica (pregabalin) , amene amatchedwa "mwana wa Neurontin."
Neurontin ndi Lyrica ndi mankhwala osokoneza bongo omwe amapezeka kuti ndi othandiza pa ululu wa matenda a shuga . Lyrica ndiye idavomerezedwa ndi FDA kwa FMS ndi Neurontin kawiri kaŵirikaŵiri imatumizidwa kuchoka pa tepi. Amagwiritsidwanso ntchito pa ululu wina, kuphatikizapo ululu wam'mbuyo-opaleshoni ndi neuralgia zakuthambo .
Mirogabalin, komabe, yapangidwa mwachindunji ndi ululu wa ubongo ndi FMS m'maganizo.
Momwe Mirogabalin Amagwirira Ntchito
Malinga ndi wopanga mankhwala osokoneza bongo a Japan Daiichi Sankyo, mirogabalin amamanga njira za calcium mu ubongo, monga Lyrica ndi Neurontin. Komabe, mirogabalin imamangirira kwambiri kuposa Lyrica, yomwe ingayambitse mavuto.
Pakalipano, zotsatira zoyipa zingakhale vuto lalikulu ndi Lyrica, Neurontin, ndi mankhwala ena a FMS. Ndipotu, anthu ambiri amasiya kumwa mankhwalawa chifukwa cha iwo. Ngati kuyembekezera koyambirira kukugwira ndipo mirogabalin imapereka mpumulo wopweteka ndi zochepa zomwe zimachitika, zingakhale zambiri kwa anthu omwe ali ndi vutoli.
Mirogabalin imakhulupiriranso kukhala yaitali kuposa Lyrica, kutanthauza kuti imayenera kuchitidwa mobwerezabwereza. Phunziro lachaka cha 2016 linapereka kuti mlingo wa tsiku ndi tsiku ukhoza kukhala wabwino kuthetsa zotsatira zoyipa.
Kwa Fibromyalgia ndi Neuropathy
Daiichi Sankyo akupanga phunziro la anthu chikwi pa mirogabalin ya FMS.
Ndilo phunziro lalikulu kwambiri (ndi lofunika kwambiri) loyambirira mwamsanga, lomwe limasonyeza kuti kampaniyo ili ndi chiyembekezo chokhudza zotsatira.
Kafukufuku wamankhwala nthawi zambiri amayerekezera mankhwala ndi placebo, koma ichi ndi pitting mirogabalin mutu ndi mutu motsutsana ndi Lyrica.
Kafukufuku amene adafalitsidwa mu 2014 adanena kuti mirogabalin adalonjeza malonjezano monga chithandizo cha matenda a shuga wodwala matendawa.
Kafukufuku waposachedwapa waganiza kuti mirogabalin ikhoza kukhala yoposa 17 kuposa Lyrica; Komabe, ochita kafukufuku ena adatsutsa zopangidwe za phunzirolo.
Mlingo
Mazira a miragabalin asanakhazikitsidwe. Kafukufuku amene anapeza katundu kamodzi kameneka katchulidwa pamwambapa akuti mlingowu ukhoza kukhala wa 17.5 mg kapena wotsika, poyerekezera ndi 150 mg ya Lyrica tsiku ndi tsiku.
Maphunziro a khunyu akugwiritsa ntchito 15 mg, 20 mg, kapena 30 mg Mlingo.
Umboni wakale umasonyeza kuti miyezo yaing'ono ingakhale yofunikira kwa omwe ali ndi mavuto ovuta kapena ovuta a impso.
Zotsatira zoyipa ndi machenjezo
Zotsatira zake ndi zotheka ndi mankhwala aliwonse ndi mazere onse a iwo samadziwika mpaka atakhala pa msika kwa zaka zingapo.
Pakali pano, kafukufuku wanena kuti mirogabalin ikhoza kugwirizanitsidwa ndi:
- chizungulire
- kugona
- kugona kwa nthawi yaitali
- mutu
Kodi Mirogabalin Adzakhala Liti?
Kafukufuku wamankhwala ndi njira yochepetsera kwambiri. Ndiyeso yoyamba yoyamba yomwe idayambira mu 2015, kuphatikizapo chiwerengero chachikulu cha ophunzira, sitingathe kuyembekezera zotsatira za zaka zingapo.
Ngati mirogabalin ikupitiriza kusonyeza lonjezo ndipo Drug Application New imayendera pamaso pa FDA, zingatenge zaka zingapo kuti izo zivomerezedwe kapena kukanidwa.
Choncho pamene tikulimbikitsidwa kudziwa kuti mankhwala opatsirana opweteka omwe amachititsa kuti pakhale zovuta zingakhalepo m'tsogolomu, tiyenera kupitiriza kufunafuna mankhwala omwe angatithandize kuthana ndi zizindikiro.
> Zotsatira:
> Boston Clinical Trials. "Kodi Zolonjezedwa Zambiri Zokhudza Mirogabalin Ndi Zotani? Maumwini onse ndi otetezedwa.
> Calandre EP, Rico-Villademoros F, Slim M. Expert akumbukira za matenda a ubongo. 2016 Jul 7: 1-15. [Epub patsogolo pa kusindikizidwa] Alpha2delta ligands, gabapentin, PGB ndi MGB: kuwunika kwa mankhwala awo azachipatala ndi ntchito zothandizira.
> Daiichi Sankyo Company, Limited. "Daiichi Sankyo Adalengeza Odwala Oyambirira Mipingo Yambiri ya Zigawo 3 za MIrogabalin." Maumwini onse ndi otetezedwa.
> Hutmacher MM, ndi al. Journal of pharmacology. 2016 Jan; 56 (1): 67-77. Kuwonetseratu kuwonetsetsa kwa maulendo opweteka tsiku ndi tsiku, ndi chizungulire ndi kusowa mtendere, kwa mirogabalin (DS-5565) odwala omwe ali ndi matenda a shuga okhudza kupweteka kwa mtima.
> Zovomerezeka Zatsopano. "Mirogabalin." Maumwini onse ndi otetezedwa.
> Vinik A, et al. Chisamaliro cha shuga. 2014 Dec; 37 (12): 3253-61. Kuchita bwino ndi chitetezo cha mirogabalin (DS-5565) pofuna kuchiza matenda odwala matenda a shuga.
> Yin OQ, et al. Journal of pharmacology. 2016 Feb; 56 (2): 203-12. Kuwonetsa mankhwala a pharmacokinetic ndi kuyimilira pofufuza kuwonongeka kwa nkhumba kwa pharmacokinetics ya mirogabalin.