Njira Yothandizira kwa Fibromyalgia
Pa January 14, 2009, FDA inavomereza Savella (milnacipran HCl) kuti ayambe kugwiritsira ntchito fibromyalgia . Savella amatchulidwa kuti ndi serotonin ndi norepinephrine yomwe imayambanso kubwereza. Mankhwalawa akhala akugwiritsidwa ntchito kwa zaka zingapo ku Ulaya ndi ku Asia kuti athetse kuvutika maganizo.
Kodi Serotonin Yosankha ndi Norepinephrine Dual Reuptake Inhibitor Ndi Chiyani?
Monga serotonin yosankhidwa ndi norepinephrine yomwe imadziwika kuti reuptake inhibitor, yomwe imadziwika kuti SSNRI, Savella imapangitsa norepinephrine ndi ntchito ya serotonin mu ubongo.
Mu chubu choyesa, Savella akuwoneka kuti ali ndi zotsatira zambiri pa ntchito ya norepinephrine. Izi ndizofunikira kwa odwala fibromyalgia chifukwa chiwerengero cha ubongo cha norepinephrine chimagwirizana kuti chikugwirizana ndi mavuto owonjezereka ndi "malingaliro a ubongo").
Kodi Savella Amapatsidwa Bwanji?
Savella imaperekedwa mu magawo awiri ogawanika patsiku. Mlingowo ukuwonjezeka pang'onopang'ono pamapeto pa sabata yoyamba kufika pa mlingo woyenera wa 100 mg / tsiku.
Savella amapezeka ngati 12.5 mg, 25 mg, 50 mg, ndi mapiritsi 100 mg. Tsiku la 1, mutenga 12.5 mg kamodzi. Pa masiku 2 mpaka 3, mumatenga 12.5 mg / kawiri pa tsiku. Pa masiku 4 mpaka 7, mumatenga 25 mg / kawiri tsiku lililonse. Patsiku la 7, mlingo wamba ndi 50 mg / kawiri tsiku lililonse. Odwala ena angafunike 200 mg / tsiku - ndipo ena angafune mlingo wotsika ngati ali ndi vuto la impso (impso).
Kodi Savella Amachitidwa Bwanji M'madokotala?
Kupulumuka ndi kuthandizira kwa Savella kunatsimikiziridwa kuchokera ku zotsatira za mayesero awiri a chigawo chachitatu ku United States Panali odwala oposa 2,000 omwe ali ndi fibromyalgia omwe amagwira nawo maphunziro.
Malingaliro a Savella
Savella amatsutsana (sayenera kugwiritsidwa ntchito) kwa odwala omwe ali ndi glaucoma yopanda mphamvu. Savella sayenera kugwiritsidwanso ntchito ndi odwala omwe amatenga MAOIs (monoamine oxidase inhibitors), omwe amagwiritsidwa ntchito poponderezedwa. Savella sichivomerezedwa kuti zigwiritsidwe ntchito kwa ana.
Machenjezo Ogwirizana ndi Savella
Odwala omwe anapatsidwa Savella ayenera kudziwa machenjezo ndi machenjezo otsatirawa:
- Kuwopsa kwa zizindikilo zowawa komanso kudzipha ndizotheka ndi Savella
- Matenda a Serotonin (zomwe zimachititsa kuti thupi likhale ndi mankhwala oopsa kwambiri a serotonin) n'zotheka.
- Kuthamanga kwa magazi komanso kuthamanga kwa mtima kumachitika ndi Savella.
- Kugonjetsedwa kwafotokozedwa kwa odwala omwe amatenga Savella.
- Mankhwala a hepatotoxicity adanenedwa (odwala omwe amamwa kwambiri mowa kapena matenda aakulu a chiwindi ayenera kupewa Savella).
- Zizindikiro zobwereka zikhoza kuchitika ngati Savella sakulephereka pang'onopang'ono.
- Savella angapangitse ngozi yoika magazi makamaka kwa odwala omwe amatenga NSAID , aspirin , kapena mankhwala ena omwe amakhudza magazi.
- Pakhoza kukhala maulendo apamwamba a zochitika zosokoneza bongo ndi Savella ntchito.
Savella adasankhidwa kukhala Mgwirizano wa C-C, ndipo amatanthawuza zoopsa za mwana wamasiye. Wopanga Savella akuti palibe maphunziro okwanira kapena osamalidwa omwe awonetsedwa kwa amayi apakati, choncho ayenera kugwiritsidwa ntchito panthawi yomwe ali ndi mimba pokhapokha ngati phindu limapangitsa kuti pakhale zoopsa kwa mwanayo.
Maphunziro ogwirizana a Savella sanachitidwe pa amayi okalamba.
Zotsatira Zowonongeka ndi Zovuta Zochitika
Khungu, kupweteka mutu, kudzimbidwa, chizungulire, kusowa tulo, kuthamanga, kutuluka thukuta, kusanza, kupweteka, ndi pakamwa youma ndizovuta zomwe zimagwirizana ndi Savella.
Zotsatira:
Savella Kulemba Zowonjezera. Savella.com. 01/08/2009.
http://www.allergan.com/assets/pdf/savella_pi
Milnacipran (Savella), Chithandizo cha Kuchiza kwa Fibromyalgia. P & T (Pharmacy & Therapeutics) P T. 2010 May; 35 (5): 261-266.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873711/