Mmene mankhwala amphamvu oterewa amathandizira khansa ya m'mawere
Chimodzi mwa mankhwala omwe amadziwika kwambiri pa khansa ya m'mawere ndi mankhwala otchedwa Taxol (paclitaxel). Ndi pakati pa mankhwala ambiri mu kalasi yotchedwa taxanes yomwe imachokera ku mtengo wa yew. (Mtengo wa yew uli mu Taxus).
Taxol ndi mankhwala opatsirana kwambiri a khansa. Zingakhale zogwira mtima pa khansa ya m'mawere kumayambiriro oyambirira komanso khansa ya m'mawere (yomwe matendawa afalikira kumbali zina za thupi), ndipo nthawi zambiri imaperekedwa pambuyo pa anthracycline pamodzi ndi mankhwala a Cytoxan .
Amagwiritsidwanso ntchito ngati opaleshoni yoperekera chotupa musanachotsedwe.
Kuwonjezera pa khansa ya m'mawere, Taxol ingagwiritsidwe ntchito pochiza mitundu yambiri ya khansa, kuphatikizapo khansa ya ovari , khansara yamapapo, ndi Kaposi's sarcoma (khansara ya mtundu yomwe imakhudza anthu omwe ali ndi matenda a AID omwe amachititsa kuti ziphuphu zisawonongeke zikukula pansi pa khungu, .
Ngati inu kapena munthu wina amene mukuwasamalira akulamulidwa Taxol pazifukwa zilizonse, izi ndi zinthu zofunika kuzidziwa za mankhwala amphamvu awa.
Momwe Izo Zimagwirira Ntchito ndi momwe Zaperekedwa
Kuti mumvetsetse momwe Taxol amagwirira ntchito, zimathandiza kumvetsa kuti maselo otupa amakula ndi ndondomeko yotchedwa mitosis-dzina lachipatala kuti ligawikane. Taxol ndi mitotic inhibitor: Imafuna kuti maselo a khansa akule mwamsanga mwa kulowa mkati mwawo ndikugwirizanitsa ndi mawonekedwe a maselo otchedwa microtubules. Mwa njira iyi, mankhwalawa amaletsa maselo a khansa kugawanitsa.
Taxol ndi madzi osakanikirana omwe ali osakanikirana ndi Cremophor EL (mafuta a polyoxyethylated castor) ndipo amaperekedwa mwa kulowetsedwa -mwazinthu zina, zimaperekedwa mwachindunji mumsana, kutanthauza kuti muyenera kupita kuchipatala kapena kuchipatala kuti mulandire.
Ndi madzi osadziwika opanda madzi, koma ndi obiriwira komanso othandizira, kotero mpope ndi wofunikira kuti uwugwiritse ntchito bwino. Ikhoza kupatsidwa ngati chemo yapamwamba, kamodzi pakatha milungu iwiri kapena itatu, kapena pamsika wochepa kamodzi pa sabata. Nthaŵi zina, Taxol imaperekedwa pang'onopang'ono pa kulowetsedwa kwa maola 24.
Zotsatira Zachimake ndi Zopinga Zogonjetsa
Mutha kumasulidwa podziwa kuti anthu ambiri amalekerera Taxol bwino, makamaka pazifukwa zochepa.
Zili ndi zotsatirapo, koma izi ndizochepa.
- Matenda a ubongo (kupweteka ndi kupweteka m'manja ndi mapazi chifukwa chokhumudwa ndi mitsempha)
- Anemia
- Neutropenia (chiopsezo chachikulu cha matenda)
- Matenda ndi minofu
- Kutaya tsitsi
- Kutopa
- Nausea
- Kuthamanga
- Kutsekula m'mimba
- Mucositis (kukwiya kwa mucous membrane mkati mwa pakamwa)
- Amenhorrea (ngati ndinu mkazi amene akusala, amasiya nthawi yanu)
- Misomali yokongola kapena yachikasu
Anthu ena akhoza kukhala ndi vuto la Taxol kapena Cremophor EL . Ikugwirizananso ndi kusabereka kwa mtsogolo. Ndipo ngati muli ndi pakati, Taxol ingawononge mwana wanu amene akukula.
Pali njira zothetsera mavuto ena omwe angayambitse zotsatirazi. Musanayambe kulandira chithandizo ndi Taxol, dokotala wanu mwinamwake mutenga mankhwala owonjezera a amino acid wotchedwa L-Glutamine pofuna kupewa matenda a ubongo; Mwinanso mungakhale ndi jekeseni ya Neupogen (filgrastim) kapena Neulasta (pegfilgrastim) kuti likhale ndi mphamvu zoyera za maselo oyera .
Mudzalangizidwa kuti musamamwe pamene mukugwiritsidwa ntchito ndi Taxol, komanso kuti muzigwiritsa ntchito njira yoberekera ngati mukugonana. Mwinamwake musakhale ndi katemera, chifukwa chitetezo chanu cha mthupi chidzasokonezeka ndipo simuyenera kutenga aspirin.
Nanga misomali yachikasu: Mungathe kuwateteza ndi msomali wa msomali.
> Zotsatira:
> Medline Plus. "Paclitaxel Injection." Feb 1, 2011.