Chifukwa Chotheka cha Kupweteka ndi Kutentha Kusokonezeka mu Fibromyalgia
Ngati mukukhala ndi fibromyalgia , mwina mukudziŵa zina mwa zokhumudwitsa. Sikuti mumangokhalira kumangokhalira kulira chifukwa palibe chifukwa chomveka, koma zikuwoneka ngati palibe amene akudziwa chifukwa chake izi zimachitika. Ndipo mpaka tidziwa chomwe chimayambitsa zizindikiro, ndi zovuta kupeza mankhwala oyenera. Izi zinati, phunziro la 2013 likhoza kuwonetsa chifukwa chachikulu cha kupweteka kwakukulu ndi zizindikiro zina zomwe zimaimira fibromyalgia.
Kubwereza Kwachidule kwa Fibromyalgia ndi Zomwe Zingatheke
Fibromyalgia ndi chikhalidwe chomwe chimabweretsa ululu wambiri ndipo chimakhudza anthu pafupifupi 6 miliyoni ku United States. Pakalipano, madokotala ayenera kubweretsa zizindikiro ndi zochitika zomwe zimapezeka kuchokera ku mbiri yakale ndi kuunika kokha. Matendawa nthawi zambiri samamvetsetsa, ndipo kukhumudwa kwa kukhala ndi chikhalidwe chomwe palibe chidziwitso chotsimikizirika chimapangitsa anthu ambiri omwe ali ndi fibromyalgia akumverera okha ndikufunsidwa ndi omwe samvetsa. Kafufuzidwe kafufuzidwe kawonekere zomwe zingayambitse fibromyalgia yakhalanso yokhumudwitsa, ndipo popanda chifukwa chodziŵika, mayesero opatsirana kapena mankhwala omwe athandizidwa kuti asinthe chifukwa chake akusowa.
Chifukwa Chotheka cha Fibromyalgia: Mitsempha Yambiri
Poganizira zowonjezera kuchokera ku mankhwala P mpaka mahomoni, ofufuza akhala akudandaula za njira zenizeni zomwe zimachokera ku zizindikiro za fibromyalgia.
Koma tsopano akunena kuti anthu omwe ali ndi fibromyalgia akhoza kukhala ndi mitsempha yowonjezereka kwambiri ku gawo lina la kayendedwe kake. "Mitsempha yowonjezera "yi imatha kuwapweteka kwambiri, kuwonetsa magazi, ndipo zimakhala zovuta kuti thupi liziyenda kutentha kwake.
Arteriole-Venule Mipikisano & Chifukwa Chake Ndizofunika
Pano pali phunziro lachidziwitso mwamsanga kuti likuthandizeni kumvetsa izi.
Mu dongosolo lanu lozungulira , muli mitundu yambiri ya mitsempha ya magazi. Magazi achoka kumbali yakumanzere ya mtima mu mitsempha yayikulu. Nthambi iyi mpaka mitsempha yaying'ono ndiyeno arterioles. Mitengo yamitengo imakhala yaying'ono komanso yaying'ono, monga momwe nthambi za mtengo zimakhalira zing'onozing'ono ndi zochepetsetsa, ndipo zimathera m'magazi a mitsempha , mitsempha yaing'ono kwambiri mwazi yomwe zimapangidwira mpweya wabwino ndi zakudya. Pogwiritsa ntchito ma capillaries, magazi amayenda kudzera m'mitsempha, kupita ku mitsempha yaikulu ndi yaikulu, potsiriza kubwerera kumanja kwa mtima.
Mitundu iwiri ya mitsempha ya mthupi imene tikuyang'ana pa chiphunzitso ichi ndi arterioles ndi mavenda. Nthawi zina, malinga ndi kusintha kwa magazi oyenera kulowa m'dera linalake la thupi, magazi amawombera ma capillaries ndipo amapita molunjika kuchokera ku arterioles kupita ku mitsempha. Ganizirani za kupopera kwa mphindi pang'ono. Arterioles ndi mitsempha ndizosiyana siyana za mapaipi, ndipo amafunika ma valve kuti agwirizane nawo. Magetsi amenewo amatchedwa shunti ya arteriole-venule (AVS.)
Mitsempha ya m'magazi imasiya kuteteza ngati magazi anu amakhala mumitsuko ikuluikulu kapena amalowa m'maselo ang'onoang'ono omwe amatchedwa capillaries. Izi ndi momwe thupi lanu limalamulira kutentha, komwe kumayendayenda thupi lanu ndi magazi. AVS imatsegulidwa ndi kutsekedwa ndi mitsempha yapadera, yomwe imazindikira kuti magazi akuyenda limodzi ndi ululu ndi kutentha.
(Mungathe kuziwona nokha mwa kuzindikira momwe thupi lanu limakhalira pinki pamene muli otenthedwa ndipo mumatuluka pamene mukuzizira.)
Phunziro ili, asayansi adapeza kuti anthu omwe ali ndi fibromyalgia anali ndi mitsempha yambiri yomwe imathawira ku AVS. Mitsempha yambiri imatanthawuzira zowonjezera zowonjezera, ndipo chifukwa chake zimakhala zopweteka kwambiri kumverera monga ululu ndi kutentha.
Zikutanthauza chiyani?
Kotero, pali mitsempha yowonjezera yomwe imayankha mopitirira muyeso ku ululu ndi kutentha, ndipo mitsempha iyi imayang'anira kuthamanga kwa arteriole-venule, koma izi zikutanthawuza chiyani? Pofufuza za chikhalidwe monga fibromyalgia tingapeze kusintha kwa thupi, koma kusintha kumeneku kumagwira ntchito bwanji.
Ndipo kusintha kumeneku kumathandiza bwanji zizindikiro zomwe timakumana nazo?
Mitsempha Yowonjezerapo Imatanthauza Zambiri "Thermostats Zambiri"
Mu phunziro ili, ofufuza adawona mitsempha ndi mitsempha ya mmanja m'manja. Sitikudziwa ngati mitsempha yowonjezerayi ili ponseponse mthupi lathu, koma ngati ili, zingathandize kufotokoza chifukwa chake anthu omwe ali ndi fibromyalgia amavulaza kulikonse. Zingathenso kufotokoza chifukwa chake zotentha zathu zamkati zili ponseponse .
Nkhani Zokhetsa Magazi
Kuphatikiza pa nkhani zowonjezereka, ndi nkhani zothamanga magazi. Magazi amanyamula oksijeni ndi zakudya ku minofu, koma ngati thupi liri ndi vuto lotsogolera kuyendetsa mwazi poyankha, mphamvuzo zimachotsedwa, choncho zimakhala zofooka. Asidi a Lactic amamangirira ndipo amachititsa kuti ziwotche zomwe zimakuyenderani bwino.
Kuwonjezera apo, kodi mwawonapo mapepala owawa-ndi-singano omwe mumamva pamene phazi kapena dzanja likugona? Chifukwa cha kuchepa kwa magazi m'madera a thupi (otchedwa ischemia), ndipo madokotala ena akhala akukhulupirira kuti ischemia imayambitsa kupweteka kwa fibromyalgia .
(Mungafunenso kuyambiranso ubale wa serotonin ndi kuthamanga kwa magazi mu fibromyalgia kwa chiphunzitso china chotsatira chifukwa chake vuto la magazi limayambira.)
Mmene Kupeza Uku Kungayambitsire Mayeso Odziwa Kuzindikira kapena Chithandizo cha Fibromyalgia
Fibromyalgia pakali pano ndi matenda opatsirana pogonana, kutanthauza kuti palibe kuyezetsa kwa magazi kapena kuphunzira kwadzidzidzi zomwe zingachititse kutsimikizira kapena kusatengera matendawa. M'malo mwake, fibromyalgia kawirikawiri imadziwika kuti yanyalanyazidwa chifukwa cha mbiri yakale, kuyerekezera thupi, ndi kulamulira zochitika zomwe tili ndi mayesero.
Ochita kafukufukuyu akukhulupirira kuti -kupeza kuti matendawa ndi ofunika kwambiri. Kuonjezera apo, popeza kuti chinthu chosadziwika chakhala chikudziwika, kuyang'ana njira zomwe zingasinthire zolakwikazo zingayambitse njira zamtsogolo zamankhwala. Zonse zomwe zikuwoneka kuti zikudalira, koma ponso phunzirani zambiri. Nthawi idzanena.
Zolephera Zotheka Phunziroli
Izi ndizofunika kukumbukira phunziroli: Linalipiritsidwa ndi makampani awiri omwe amapanga mankhwala a fibromyalgia Cymbalta (duloxetine) ndi Savella (milnacipran.) Kusindikizidwa pazomwekupeza kuti mitsempha yambiri ndiyo chifukwa chake mankhwalawa akugwira ntchito; angathandize kuthandizira mitsempha yowonjezereka. Zomwe akupezazi zikubweretsa kukayikira za mankhwala atsopano monga makampani osokoneza bongo sakhala ndi chizoloŵezi chofuna mankhwala atsopano pamene angathe kulimbikitsa malonda awo omwe ali kale kumsika.
Komanso, phunziroli linali laling'ono ndi amayi 24 okha. Tifunika kufufuza zambiri tisananene, mosakayikira kuti izi ndi zomwe zikuchitika mthupi lathu. Ichi ndi chiphunzitso chochititsa chidwi chomwe chiyenera kupitiliza kuphunzira, koma mwachidwi kuti akatswiri ena azitsatira kuti azikhala ndi nkhawa.
Pansi pa Mitsempha Yambiri Momwe Mungathetsere Zizindikiro za Fibromyalgia
Chiphunzitso chakuti zizindikiro za fibromyalgia zikhoza kukhala zokhudzana ndi mitsempha yochulukirapo kwa AV shutsti zomwe zimapangitsa ululu ndi kutentha kwadontho kumakhala kosangalatsa. Ngati pali chiphunzitso ichi, sizingangowonjezera kuti chidziwitso cha matenda a fibromyalgia chingakonzedwe, koma mankhwala omwe akuwongolera zolakwikazi angapangidwe chimodzimodzi. Monga taonera, phunziro lomwe tinalongosola apa linali laling'ono, ndipo kufufuza kwina kuli kofunika kuti mudziwe ngati kuli koyenera kufufuza
Kwa anthu omwe ali ndi vuto lachikhalidwe chomwe sichingakhale chopweteka koma alibe chidziwitso chotsimikizirika, lingaliro ili lingathe kuchepetsa manyazi ndi kudzipatula omwe ali ndi zizindikiro za kukhala ndi matenda osamvetsetseka.
> Zotsatira:
> Albrecht, P., Hou, Q., Argoff, C., Storey, J., Wymer, J., ndi F. Rice. Kuchuluka kwa Peptidergic Sensory Innoring of Cutaneous Arteriole-Venule Nsonga (AVS) mu Khungu la Palmar Lalikulu la Odwala a Fibromyalgia: Zotsatira za Mafala Ozama Kwambiri Ndi Kutopa. Kupweteka kwa mankhwala . 2013. 14 (6): 895-915.
> Albrecht, P., ndi F. Rice. Matenda a Fibromyalgia Syndrome Mavuto a Chilengedwe ndi Zochitika Zachilengedwe pa Mavuto Ndi Machiritsi Osadziwika. Ndemanga za Environmental Health . 2016. 31 (2): 281-94.
> Sluka, K., ndi D. Clauw. Neurobiology ya Fibromyalgia ndi Mavuto Ofala Kwambiri. Neuroscience . 2016. 338: 114-129.