Kodi Kutsekula m'mimba ku IBS Kungakhale Kofananako ndi Mavuto a Matenda a Malabsorption?
Pofuna kumvetsetsa bwino kwambiri zinthu zomwe zimayambitsa matenda a m'mimba (IBS), ofufuza ena atembenukira ku chidziwitso cha idiopathic bile acid malabsorption (I-BAM).
Kodi I-BAM ndi chiyani?
Mafuta acid ndi zinthu zomwe zimapangidwa ndi chiwindi ndi kusungidwa mu ndulu . Asidi amathandiza kuthandizira mafuta, omwe amapezeka m'mimba mwawe.
Kawirikawiri, mankhwala a bile ndi amtumbo ochepa ndipo amabwerera ku chiwindi kuti agwiritsidwe ntchito ndipo amagwiritsidwa ntchito katatu patsiku. Nkhuta zochepa zokha za asidi (5 peresenti) zimadutsa pamtunda, matumbo akuluakulu .
Koma ngati bile yambiri imatulutsa njira yotsegula m'matumbo akuluakulu, imayambitsa kusungunuka kwa madzi, zomwe zimapangitsa kuti zikhale zotayirira, madzi ndi kutsekula m'mimba. Matendawa amadziwika kuti bile acid malabsorption (BAM). Ngati palibe matenda omwe amadziwika kuti ali ndi matenda kapena kuvulala, matendawa amakhala ngati mtundu 2 BAM, wotchedwa idiopathic kapena primary BAM (I-BAM kapena P-BAM).
I-BAM kawirikawiri amaganiziridwa kuti ndi chinthu chosowa. Komabe, kafukufuku wa kafukufuku anapeza kuti pafupifupi 25 mpaka 30 peresenti ya odwala okhala ndi zizindikiro za mtundu wa IBS-D amayesedwa bwino kwa I-BAM pogwiritsa ntchito sewero la 75SeHCAT.
Monga mbali ya ndondomekoyi, deta inasonyeza kuti odwala amapatsidwa mankhwala okwanira omwe ali ndi acid acid omwe amagwiritsidwa ntchito mofanana ndi momwe amachitira matendawa.
Ochita kafukufukuwo akuganiza kuti sindinadziwe bwinobwino za I-BAM chifukwa cha kusadziŵa za kufalikira kwake komanso kusowa kwa kuthandizira (sikunapezeke ku US) kungakhale kutsogolera odwala ambiri a IBS-D osalandira chithandizo choyenera ndi choyenera .
Lingaliro Lomwe Lingatheke
Ochita kafukufuku akhala akuyesera kuti amvetsetse zomwe zingathetse vutoli la acid malabsorption.
Chomwe chimakhala choyipa ndi mtundu wina wa maatoni, FGF19, womwe uli ndi udindo woyang'anira bile acid acid. Zingakhale zochepa kwambiri za homoni iyi chifukwa chimakhala ndi mavitamini ambirimbiri omwe amachititsa kuti m'mimba mwake mulowe m'mimba. Kafukufuku akupitirizabe kumvetsetsa vutoli, ndi chiyembekezo kuti zingayambitse mankhwala omwe amatsogoletsa vutoli.
Mfundo Yofunika Kwambiri
Chochititsa chidwi ndi chiwerengero cha 25 mpaka 30 peresenti, ndikofunika kuzindikira kuti dera ili lafukufuku likuwoneka ngati likuyendetsedwa ndi gulu lina la ofufuza. Ndipo, mwatsoka, ngati kanthano ka 75SeHCAT sikapezeke ku US, sizili ngati ngati mwadzidzidzi muli mayeso a magazi kuti mudziwe ngati IBS-D yanu ndi I-BAM. Komabe, ngati mutakhala ndi zotayirira, madzi ngati gawo la chithunzi cha chizindikiro chanu, mungafune kuyankhula ndi dokotala wanu kuti muwone ngati mungakhale woyesedwa kuti muyese mankhwala omwe akugwiritsidwa ntchito pochiza BAM.
Zotsatira:
Pattni, S. & Walters, J. "Kupitako patsogolo posintha bile acid malabsorption" British Medical Bulletin 2009 92: 79-93.
Walters, J. "Kutanthauzira primary bile acid m'mimba: kupanga matenda ndi kuzindikira matendawa" Expert Reviews 2010 4: 561-567.
Wedlake, L., et.al. "Kukonzekera mwatsatanetsatane: kufalikira kwa idiopathic bile acid malabsorption monga momwe anapezera ndi SeHCAT kusanthula kwa odwala otsekula m'mimba-omwe amachititsa kuti thupi likhale lopweteka kwambiri" Matenda a Pharmacology and Therapeutics 2009 30: 707-717.
Walters, J. "Kutanthauzira primary bile acid m'mimba: kupanga matenda ndi kuzindikira matendawa" Expert Reviews 2010 4: 561-567.