Njira zitatu zamagulu a mitsempha ndizopakati pa mitsempha ya ubongo (ubongo ndi msana), mawonekedwe a mitsempha ya m'mimba (ziwalo ndi ziwalo), ndi dongosolo lodzidzimitsa la mitsempha (njira yolamulira, kusunga homeostasis mu thupi). Udindo wa lupus mu dongosolo lachitetezo chaumadzi sichidziwika bwino.
Mwachidule, tidzakambirana makamaka za dongosolo la mitsempha ndi njira zina zomwe lupus zimakhudzira dongosolo.
Pulogalamu Yamkati Yamkati
Zotsatira za lupus m'katikatikatikati mwa mitsempha ndizozama. Lupus ikhoza kuyambitsa mavuto ambiri amachitidwe a mitsempha, kuphatikizapo, koma osangokhalira, kusokonezeka kwa chidziwitso, kupweteka, kugunda, ndi mutu. Matendawa akhoza kukhala okhudzana ndi vasculopathy (matenda okhudza mitsempha ya magazi), autoantibodies, kuthamanga kwa mtima ndi mitsempha yotupa. Odwala Lupus angakhalenso ndi mitsempha yapakati ya mitsempha ya vasculitis.
Mitsempha ya m'mitsempha yapakati ya vasculitis (CNS vasculitis) imatanthawuza kuti kutupa kwa ubongo ndi mitsempha ya mitsempha ya msana ndipo mwina ndi vuto lalikulu kwambiri lomwe limagwirizanitsidwa ndi systemic lupus erythematosus (SLE). Kupezeka kwake monga matenda oyambirira sikungowonjezereka kusiyana ndi zomwe zimachitika ngati matenda achiwiri, monga ndi SLE.
Zizindikilo za pakatikati za mitsempha yotchedwa vasculitis zimaphatikizapo kutentha kwambiri, kupweteka (nthawi imodzi kapena kupitilira), psychosis, kuuma kwa khosi, ndi kupwetekedwa mtima komwe sikulimbana ndi mankhwala ochiritsira.
Kugonjetsa ndi zilonda zingakhale zopanda matenda a vasculitis ndipo zingakhale zogwirizana ndi autoantibodies zomwe zimawonjezera chiopsezo cha kupwetekedwa.
Nthendayi ya CNS ndi yovuta kufotokoza ndipo nthawi zina imatengedwa kuti imapezeka ndi gulu. Mayesero ambiri, monga CT (computed tomography) amawoneka, MRIs (kujambula zithunzi za magnetic resonance), ndi zitsanzo zamadzimadzi a msana zimapereka zizindikiro zambiri kuposa kudziwunikira.
Izi ndizofotokozedwa kwambiri, koma atapezeka, madokotala akhoza kuthandizira zowona CNS vasculitis mwa kuphatikiza kwa mlingo waukulu wa corticosteroids ndi cyclophosphamide, woperekedwa kuchipatala.
Pafupifupi 10 peresenti ya odwala onse a lupus angakumane ndi mtundu uwu wa vasculitis ndipo ndiyo njira yokhayo ya matenda oyambitsa matenda amanjenje omwe ali mu American College of Rheumatology zoyenera kufotokozera SLE.
Kusokonezeka Maganizo
Odwala Lupus akhoza, panthawi zina pamoyo wawo, akumva kusokonezeka, amavutika kudzifotokozera okha, ndikupeza kufooka kwa kukumbukira, zonse zomwe zimayenderana ndi matenda awo. Pamodzi, zizindikiro ndi zizindikirozi zimatchedwa kusokonezeka kwa chidziwitso . Chifukwa chomwe amachitira ndi lupus sichidziwika.
Zizindikiro zomwe zimagwirizanitsidwa ndi kusokonezeka kwa chidziwitso kawirikawiri zimayendetsedwa ndi antitimalarials kapena corticosteroids. Mankhwala ena amatha kukhala othandiza.
Mutu
Mutu umagwirizanitsa lupus ndi ofanana ndi migraines mwamphamvu ndipo kawirikawiri amachitiranso chimodzimodzi. Corticosteroids ingathandizenso.
Fibromyalgia
Akuti pafupifupi 20 peresenti ya anthu omwe akudwala SLE ali ndi fibromyalgia, matenda omwe amabweretsa ululu ndi kutopa m'madera ena a thupi, monga khosi, mapewa, kumbuyo, m'chiuno, mikono, ndi miyendo.
Amatchedwa "zizindikiro zachifundo" chifukwa ali achisoni. Izi nthawi zambiri zimachiritsidwa ndi mankhwala opweteka ndi mankhwala, pamene zotsatira zapadera za matendawa zimachiritsidwa ndi antidepressants ndi uphungu.
Zimene Dokotala Wanu Amafuna Kudziwa
Ndikofunika kuti dokotala wanu adziwe ngati mukudwala zizindikiro kapena zizindikiro zomwe zingagwirizane ndi dongosolo lamanjenje. Dokotala wanu akufuna kudziwa chifukwa chenichenicho.
Akhoza kuyesa mayesero angapo, kuphatikizapo kuunika kwa thupi ndi kafukufuku wa ma laboratory, omwe angaphatikizepo ntchito ya magazi ndi urinalysis. Zitsanzo zenizeni zodziwitsa ndi kuzindikira momwe maselo amachititsira lupus kuphatikizapo:
- Kuyeza kwapadera, kuyesedwa kosasamala kwapadera komwe kumayendera moyenera momwe kutupa kulili m'thupi.
- Mayeso a ANA (antinuclear antibody), omwe amadziwika kuti autoantibodies omwe amaukira thupi ndi maselo.
- Kuyezetsa magazi kwa DNA, komwe kumatsimikizira ngati pali ma antibodies opangidwa ku ma genetic mu selo.
- Mankhwala oletsa anti-ribosomal P.
- Kuphatikizidwa, kuyezetsa mwazi komwe kumayesa ntchito ya mapuloteni ena mu gawo lamagazi la magazi anu.
Dokotala wanu angayambitsenso mayeso osiyanasiyana monga CT, SPECT, kapena MRI yomwe imatulutsa, electroencephalogram, phokoso la msana (kuyang'ana maselo, mapuloteni, ndi ma antibodies), kapena PET (positron emission) sewero la tomography).
Chithandizo
Mankhwala amodzi amadziwika m'magulu apamwamba, koma ziyenera kuzindikila kuti kuyankhidwa kwa chithandizo chamankhwala kumapangitsa kuti maseĊµerawo achoke mwatsatanetsatane. Koma kwa ambiri, kugwiritsidwa ntchito kwa mitsempha kumasinthidwa kwathunthu.
Zotsatira:
> Nervous System. Lupus Foundation ya America. January 2008.
> Kodi Vasculitis ndi chiyani ?. National Heart, Lung ndi Magazi Institute. August 2006.
> Zimene Mukuyenera Kudziwa Zokhudza Mapulogalamu Aakulu Amtundu wa Vasculitis. Clinical Cleveland. Dipatimenti ya Rheumatic ndi Immunologic Diseases. October 2006.
Mfundo Zachidule Zokhudza Fibromyalgia. National Institute of Arthritis ndi Musculoskeletal ndi Matenda a Khungu.