Chithandizo china Chithandizo
Pali njira zosiyanasiyana zochizira anthu omwe ali ndi psoriasis kapena psoriatic nyamakazi. Chinthu chimodzi chochepa chomwe chimagwiritsidwa ntchito ndi mankhwala a lefilunomide. Zingakhale zomveka kwa inu ngati matenda anu sakuyankha bwino, kapena ngati simungathe kumwa mankhwala ena.
Kodi Leflunomide ndi chiyani?
Leflunomide (dzina la malonda Arava) ndi mankhwala osokoneza bongo omwe angagwiritsidwe ntchito pochiza nyamakazi ya psoriatic ndi psoriasis yovuta kwambiri.
Dzina la mankhwalawa ndi N- (4'-trifluoromethylphenyl) -5-methylisoxazole-4-carboxamide.
A FDA poyamba adavomereza kuti mankhwala a nyamakazi ayambe kudwala. Malingaliro apadera, malipiro amtundu wa FDA sanavomerezedwe kuti awononge psoriasis ndi psoriatic nyamakazi-mayesero oyenerera a kuchipatala sanachitike. Komabe, psoriasis ndi nyamakazi ya nyamakazi zimakhala zozizira kwambiri zomwe zingakhudze ziwalo, ndipo zimagawana zofanana za thupi. Maphunziro ena a zachipatala amasonyeza kuti leflunomide imathandiza kuthetsa zizindikiro za khungu la psoriasis komanso zizindikiro zonse za khungu ndi ziwalo kwa anthu omwe ali ndi nyamakazi ya psoriatic. Choncho madokotala nthawi zina amapereka mankhwalawa "kuchoka pa label."
Leflunomide ndi imodzi mwa mankhwala akale omwe angagwiritsidwe ntchito pochiza psoriasis ndi psoriatic nyamakazi. Izi zimaika gulu limodzi ndi methotrexate, cyclosporine, ndi mankhwala ena.
Komabe, mankhwalawa sagwiritsidwa ntchito mofanana monga mankhwala enawa. Mungamve mankhwala awa otchedwa DMARD kapena mankhwala othandizira mankhwala oletsa antirheumatic. Monga mankhwala awa, leflunomide si imodzi mwa mankhwala atsopano "a biologic" omwe amapangidwa kuchokera ku mapuloteni a anthu kapena a nyama.
Kodi Leflunomide Zimagwira Ntchito Bwanji?
Ntchito ya Leflunomide siidziwika bwino.
Komabe, zikuwoneka kuti zimagwira ntchito mochepa mwa kulepheretsa ma enzyme oyenera kupanga DNA yatsopano (zakuthupi zomwe mwabadwa nazo). Pamene kutupa kumachitika, thupi lanu limapanga maselo atsopano oteteza thupi. Pochepetsa pang'onopang'ono DNA, kapangidwe kake kamatha kulepheretsa kutupa komwe kumayambitsa zizindikiro za psoriasis ndi psoratic arthritis. Komabe, chifukwa chimadwalitsa chitetezo cha mthupi, chikhoza kukhala ndi zotsatira zina.
Kodi Ndikutenga Bwanji Leflunomide?
Tengani mafuta pamlingo ndi chakudya, monga momwe adanenera. Mankhwalawa amapezeka mu 10mg, 20mg, ndi mamita 100mg. Pamene mumayambitsa mankhwalawa, dokotala wanu angakupatseni mlingo waukulu kuposa wotchuka, wotchedwa "kulandira mlingo" (kawirikawiri 100mg masiku atatu). Pambuyo pa mankhwala osokoneza bongo mutuluka mumthupi mwako, mutenga mlingo wochepetsetsa (pafupifupi 20mg tsiku lililonse).
Ndani Amapindula ndi Leflunomide?
Palinso mankhwala osiyanasiyana ochiritsira pakamwa pofuna kuchiza psoriasis, monga methotrexate. Mankhwala ena atsopano monga " biologic " monga Enbrel (etanercept) amapezeka. Madokotala nthawi zambiri amapereka mankhwala okhaokha pambuyo poti njira zina zamankhwala sizinapambane. Komabe, mankhwala atsopano a biologic ayenera kutengedwa kudzera mu mitsempha, ndipo ndi okwera mtengo kuposa mankhwala osakhala a biologic.
Ngati mankhwala ena osokoneza bongo sanakugwiritseni ntchito, mungayesetse kuyesa masewera musanasamukire ku biologic mankhwala. Nthaŵi zina, dokotala wanu angapereke mankhwala amodzi pokhapokha ku mankhwala ena am'lomo, monga methotrexate.
Anthu omwe ali ndi psoriasis wofatsa amayenera kugwiritsa ntchito mankhwala opatsirana ndi mankhwala osati mankhwala osokoneza bongo.
Zomwe Zingatheke za Leflunomide
Zina mwa zotsatira zofala za lefilumide zimachokera ku mkwiyo wa m'mimba. Mwachitsanzo, awa angaphatikizepo:
- Kutsekula m'mimba (kotchuka kwambiri)
- Nausea
- Zimakhumudwa m'mimba
Zina mwa zotsatira zake zingakhale:
- Chimake (chosavuta kwambiri)
- Kutaya tsitsi
- Mavitamini a chiwindi (omwe amawonetsa chiwonongeko cha chiwindi)
- Kuwonjezeka kwa chiopsezo cha matenda
- Kuchepetsa maselo a magazi kapena mapulogalamu (kuchokera kuchepa kwa kupanga mafuta m'nthaka)
Zina zoipa zotsatira zake ndi:
- Pulmonary fibrosis
- Ululu wokodza
- Zizindikiro za ubongo monga kusokonezeka kapena chizungulire
Zitsanzo ndi Kuyezetsa Maphunziro Pogwiritsa Ntchito Leflunomide
Musanayambe malipiro anu, dokotala wanu adzatenga mbiri yanu yachipatala ndikuyesera. Izi zimathandiza dokotala wanu kutsimikizira kuti palibe chifukwa chimene lefilunomide chingakhale chosankha choipa kwa inu. Onetsetsani kuuza dokotala wanu za mankhwala omwe mumatenga, kuphatikizapo mankhwala owonjezera. Izi zingakhudze mphamvu ya masewera komanso ngozi zake.
Chifukwa cha chiopsezo cha zotsatira zina za mankhwala, anthu omwe amatenga leflunomide amafunikira mayesero enaake a ma laboratory nthawi zonse. Mudzafunika izi musanayambe kulandira mankhwala komanso nthawi zonse. Mwachitsanzo, mungafunike mayesero awa:
- Kuwerengera magazi nthawi zonse (kuyang'anira maselo ofiira a magazi, maselo oyera a magazi, ndi mapulateletti)
- Mayeso a chiwindi, monga ALT
Anthu omwe amatenga lefilumoni amafunikanso kuyesedwa koyeso koyeso kuti athetse kuti alibe chifuwa chachikulu cha TB. (Mankhwala osokoneza bongo amatha kupangitsa kuti matendawa agwire ntchito.)
Katemera ndi Leflunomide
Anthu omwe amatenga malasitomu sayenera kukhala ndi mitundu ina ya katemera yomwe ili ndi kachilombo koyambitsa matenda. Izi sizikutanthauza kuti musagwiritse ntchito katemera onse. Mukhoza kupeza katemera wina (monga chifuwa chachikulu cha tetanasi ) musanayambe kumwa mankhwala.
Ndani Sangathe Kutenga Leflunomide?
Musagwiritse ntchito mankhwala osokoneza bongo ngati muli ndi zovuta zodziwika ndi mankhwala kapena chimodzi mwa zigawo zake. Iyenso sayenera kutenga masewera ngati chitetezo chanu cha mthupi chimasokonezedwa ndi zotsatirazi:
- Matenda aakulu a immunodeficiency
- Mavuto omwe alipo alipo ndi mafupa anu
- Matenda aakulu omwe sali olamulidwa
Azimayi sayenera kutengapo mbali.
Kubereka Ana Potsogolo ndi Leflunomide
Leflunomide ndi mankhwala a mtundu X panthaŵi ya mimba, zomwe zikutanthauza kuti zoopsa zodziwika za mankhwalawa zimaposa phindu lililonse. Zikuganiziridwa kuti ziwonjezere chiopsezo cha imfa ya fetus ndi zilema zobereka. Azimayi onse ofunika kubereka ayenera kuyesedwa mimba asanayambe mankhwala. Muyenera kupitiriza kugwiritsa ntchito njira yodalirika yobereka nthawi yonse yomwe mumatenga ndalama.
Ngati mutenga mchere ndikukhala ndi pakati, pitani ku ofesi ya dokotala nthawi yomweyo ndikuwauza zomwe mukukumana nazo. Dokotala wanu angakuuzeni za ngozi yomwe mungakhale nayo kuti mukhale ndi mimba. Dokotala wanu akhoza kulemba mankhwala osokoneza bongo (otchedwa cholestyramine) omwe angachepetse msangamsanga kuika kwa mankhwala. Izi zimachepetsa chiopsezo chovulaza mwana.
Ngati mutenga mimba ndipo mukufuna kukhala ndi pakati, lankhulani ndi dokotala musanayambe kuganiza. Ndikoyenera kuti amayi onse a msinkhu wobereka adutse mowa mwauchidakwa kuti apite mofulumira kwambiri. Izi ndizofunikira kwambiri kuti amayi ayesere kugona. Popanda kupyolera mu sitepe iyi, zingatenge zaka ziwiri kuti misonkho ikhale yotetezeka kwa thupi lanu. Azimayi sayenera kutenganso mafinya pamene akuyamwitsa.
Asayansi amakhulupirira kuti malipiro amtunduwu sakhala ndi chiopsezo cha kubereka kwa abambo kwa abambo obereka ana. Komabe, maphunziro a zinyama awa sanachitidwe. Pofuna kupewa chiopsezo chilichonse, abambo ayenera kusiya kumwa mankhwalawa asanayesere kutenga pakati. Momwemonso iwo ayenera kudutsa mu mankhwala osokoneza bongo.
Mawu Ochokera
Mwamwayi, pakali pano pali njira zingapo kwa anthu okhala ndi psoriasis kapena psoriatic nyamakazi. Leflunomide ikhoza kukhala chinthu chimodzi choyenera kuganizira ngati zomwe mwayesa sizinayambitse bwino matenda anu.
> Zotsatira:
> Arava. Kufotokozera Information . Bridgewater, NJ: Sanofi-Aventis; 2010.
> Leflunomide (Arava). American College of Rheumatology. Chiwongola dzanja Kusinthidwa kwa March 2017.
> Wowonjezera A, Korman NJ, Elmets CA, et al. Malangizo othandizira kusamalira ma psoriasis ndi psoriatic nyamakazi: gawo 4. Malangizo othandizira kusamalira ndi chithandizo cha psoriasis ndi azitsamba. J Am Acad Dermatol . 2009; 61 (3): 451-85. lembani: 10.1016 / j.jaad.2009.03.027.