Chimodzi mwa mikhalidwe yapadera ya kansa ya prostate ndiyo kuyankha kwa kuchotsedwa kwa testosterone . Izi "Achilles Heel" za khansa ya prostate zinapezeka mu 1940 pamene kutsegula kwa makoswewo kunawonetsedwera kuti liwononge matenda a khansa. Mu 1985, Lupron, mankhwala opangidwa ndi jekeseni omwe anachita chinthu chomwecho adavomerezedwa ndi FDA.
Lupron amagwira ntchito pogwiritsa ntchito makoswe kuti asatseke testosterone.
Mphamvu
Lupron imayendetsa khansa ya prostate kwa zaka ziwiri mpaka zisanu ndi chimodzi mwa amuna omwe ali ndi matenda oopsa, ndipo kwa zaka zoposa khumi pamene mankhwala ayambitsidwa musanayambe matenda a metastatic. Pamene Lupron ayima kugwira ntchito, mavitamini ena monga Casodex kapena Nilandron angapereke chithandizo cha kanthaŵi kochepa, koma nthawi yayitali (kusunga PSA pansi) kawirikawiri kumakhala osachepera chaka chimodzi.
Kutsutsana kwakhala kovuta mu maphunziro kuti ngati kuchepa kwa PSA kuwonetsa molondola kuti kupulumuka kwa wodwalayo kudzapitilira. Choncho, masiku ano, FDA ikhoza kuvomerezana ndi mankhwala atsopano ngati mankhwala opanga mankhwala akulemba bwino kuti apulumuke mu mayesero omwe amayang'aniridwa ndi placebo. Kuonetsetsa kuti kupulumuka kwabwino ndi vuto lalikulu kuposa kungosonyeza kuti mankhwala amachititsa kuchepa kwa PSA.
Zytiga (abiraterone) yomwe idaphunzitsidwa ndi amuna omwe ali ndi matenda oopsa omwe anali atagonjetsedwa ndi Lupron anatsimikizira kuti anthu odziperekawa omwe ali ndi kansa ya prostate yosagwiritsidwa ntchito ndi Lupron omwe analandira abiraterone adasonyezedwa kuti amakhala ndi 33% kuposa amuna omwe adalandira placebo.
Zytiga ndi mankhwala opanga mankhwala omwe amagwiritsira ntchito pogwiritsa ntchito zomwe zaposachedwapa zomwe zotsutsa Lupron (zomwe zimatchedwa kansa kukula ngakhale testosterone zero m'magazi) sizotsatira za maselo a khansa omwe adaphunzira kukula popanda testosterone.
M'malo mwake, kupopera kwa Lupron ndiko chifukwa cha maselo a kansa ya prostate ataphunzira momwe angapangire testosterone awo mkati.
Zomwe zimagwiritsidwa ntchito popanga mankhwala zimagwira ntchito potseka kachipangizo kamene kakupezeka mkati mwa khansa yeniyeni, yomwe imayambitsa njira ya testosterone. Zotsatira zake zimakhala kuti kansalu ya khansa imatsekedwa kuchoka ku testosterone yake.
Zotsatira Zotsatira
Zotsatira za Zytiga zingaphatikizepo kusintha kwa ma potaziyamu m'magazi, ndipo nthawi zambiri, kutayirira kwa chiwindi. Zytiga imathandizanso kuti mapiritsi a kolesteroliti azikhala ngati Lipitor ndi Crestor kotero kuti mlingo wawo uyenera kuchepetsedwa.
Kusunga ma potaziyamu mu Zytiga wodalirika kumaperekedwa mogwirizana ndi prednisone , mtundu wa cortisone. Cortisone ingakhalenso ndi zotsatira zina. Nthawi zina zimagwirizanitsidwa ndi zilonda zam'mimba ndi zilonda zakumimba. Mankhwala a shuga a pamwamba amatha kupezeka ndi anthu omwe ali ndi shuga.