Ngati cholesterol yanu ili pamwamba, wothandizira zaumoyo wanu angasankhe kuwonjezera sequestrant ya bile acid ku regimen yanu yochepetsetsa mafuta. Mafuta a acid acid, omwe amatchedwanso bile acid resins kapena BARs, ndi kalasi ya mankhwala omwe amathandiza kuchepetsa makasitomala anu. Pakalipano, mankhwala atatu m'kalasi ili akupezeka ku United States:
- Wophunzira (colestipol)
- Welchol (colesevelam)
- Questran (cholestyramine)
Welchol (colesevelam) amapezeka ngati piritsi kapena utomoni wa ufa. Colestid (colestipol) ndi Questran (cholestyramine) zimapezeka pokhapokha ngati ufa wa utomoni.
Kodi Mafupa Amadzimadzi Amatsitsa Bwanji Cholesteroliti Yanu?
Mankhwalawa amagwiritsidwa ntchito pomangirira ndi acids ndikuletsa kutsekemera kwa bile acid kuchokera m'mimba yaing'ono. Mmalo molowa mu magazi, kuphatikiza kwa bile acids ndipo mankhwalawa amachotsedwa mu nyansi. Poyankha kuchepetsa bile acids mu thupi, chiwindi chanu chimasintha cholesterol mu zambiri zamchere. Kuwonjezera pamenepo, amalandila a LDL adzawonjezeredwa m'chiwindi. Zochita zimenezi zimathandiza kuchepetsa ma cholesterol m'magazi.
Chotsatira chake, ndi acid acid sequestrants makamaka kuchepetsa LDL cholesterol pakati 15% mpaka 30% ndipo pang'ono kukweza HDL cholesterol pafupifupi 3% mpaka 5%.
Mankhwalawa samawoneka kuti amakhudza magulu a triglyceride koma, nthawi zina, bile acid sequestrants akhoza kwenikweni kutulutsa triglycerides ngati amatengedwa kwa nthawi yaitali.
Chifukwa chakuti sanatsimikizidwe kuchepetsa chiopsezo cha mtima kapena kupwetekedwa mtima, bile acid sequestrants si monga momwe anthu ambiri amalembera monga mankhwala ena otsika kwa mafuta m'thupi, makamaka statins. Komabe, amatha kutengedwa okha kapena kuphatikizapo mankhwala ena otsika kwa kolesitoloni kuti akuthandizeni kuyendetsa bwino mankhwala anu.
Zotsatira Zowonongeka za Bile Acid Sequestrants
Zotsatira za kutenga acid acid sequestrants makamaka zimakhala ndi m'mimba mavuto, kuphatikizapo:
- Nausea
- Kutsekedwa
- Kutseka
- Flatulence
Zotsatira zake zimatha kuyendetsedwa ndi kuwonjezerako kudya kwa madzimadzi, kutenga chochepetsera choponderezeka kapena kuwonjezera zakudya zamagetsi.
Anthu ena angavutike kuti azitenga nthawi zonse mankhwala awo a bile acid sequestrant. Mwachitsanzo, anthu ena angapeze kuti ma resin akhale okhwima kwambiri - makamaka ngati atenga nthawi yochuluka pa tsiku. Ngakhale pali njira zowonjezera kukoma kwa utomoni, ena amatenga mankhwalawo sangathe kulekerera kukoma kwawo. Kuwonjezera pamenepo, piritsi la Welchol ndi lalikulu ndipo zingakhale zovuta kuzimeza kwa anthu ena. Ngati mwalangizidwa kuti mukhale ndi acid acid sequestrant ndipo mukuvutika kutenga mankhwala anu, muyenera kulola wothandizira zaumoyo wanu kudziwa izi.
Ndani sayenera kutenga mchere wa sequestrant?
Zina kupatula kufotokoza mbiri yanu yachipatala, muyenera kudziwitsa wothandizira zaumoyo wanu ngati muli ndi zina mwazifukwa izi:
- Ngati muli ndi magulu akuluakulu a triglyceride kapena omwe mwakhala mukukumanapo ndi mankhwala chifukwa cha triglycerides yapamwamba kwambiri, monga chifuwa chachikulu. Izi ndi chifukwa chakuti bile acid sequestrants angadzetse mapulaneti anu triglyceride patsogolo.
- Mafuta omwe amamwa mankhwalawa amatha kugwirizana ndi mavitamini ena kapena mankhwala ena omwe mukuwatenga. Choncho, muyenera kudziwitsa anthu onse omwe ali ndi chithandizo chamankhwala ngati mukufuna kutenga mankhwala a bile acid sequestrant kuti athe kuonetsetsa kuti mankhwalawa sakugwirizana ndi mankhwala ena onse, mavitamini kapena mavitamini omwe mukuwatenga. Nthaŵi zina, wothandizira zaumoyo wanu angafunse kuti muwonjezere kuchuluka kwa nthawi pakati pa kutenga bile acid sequestrant ndi mankhwala ena.
- Zomwe anthu ochita masewera olimbitsa thupi samadziwika sizinaphunzirepo kwa amayi omwe akuyamwitsa kapena omwe ali ndi pakati. Ngakhale kuti bile acid sequestrants samawoneka kuti alowa m'magazi, akhoza kuchepetsa kuyamwa kwa mavitamini ena ofunikira.
- Ngati muli ndi mimba, monga mafinya kapena kudzimbidwa, kutenga acid acid sequestrants kungapweteke mikhalidwe imeneyi. Kuonjezerapo, muyenera kulola wothandizira zaumoyo wanu kudziwa ngati mwakhalapo ndi chitetezo cha m'mimba.
Wopereka chithandizo chaumoyo wanu adzayesa ubwino ndi zoopsa za kulongosola sequestrant ya bile acid kwa inu mu zochitika izi kuti akuthandizeni kusamalira lipids.
> Zotsatira:
> Dipiro JT, Talbert RL. Pharmacotherapy: Njira ya Pathophysiological, 9th, 2014.