Livalo (Pitavastatin)

Livalo (pitavastatin) ndi mankhwala otsika kwa mafuta m'thupi omwe ali m'gulu la mankhwala osokoneza bongo. Amagwiritsiridwa ntchito kukweza mapiritsi m'munsi mwa hyperlipidemia kapenanso matenda osokoneza bongo pamene zakudya, kusintha kwa moyo, kapena mankhwala ena sizitha kuchepetsa chiwerengero cha mankhwala. Livalo ndi imodzi mwa maonekedwe abwino kwambiri pamsika.

Malingana ndi kafukufuku, opanga mabuku a Livalo, 2 mg ya Livalo ndi othandiza kuchepetsa lipids monga 10 mg ya Lipitor (atorvastatin).

Kuwonjezera pamenepo, 2 mg ya Livalo imachepetsa mafuta m'thupi kwambiri mpaka pafupifupi 20 mg ya Zocor (simvastatin). Monga ma statins ena, Livalo imakhudza mbali zonse za mbiri yanu ya cholesterol: Ichepetsa LDL ndi triglycerides ndikukweza HDL . Maphunziro apadera owona momwe buku la Livalo likugwirira ntchito pazitsulo zakusonyeza kuti:

• Cholesterol ya LDL imachepetsedwa mpaka 44%
• Mafuta onse a mafuta a m'thupi amatsitsidwa ndi 32%.
• Triglycerides imatsitsidwa ndi 19%.
• Ma CDL a cholesterol amawonjezeka ndi pafupifupi 5%.
• Apolipoprotein B imachepetsedwa ndi pafupi 35%.

Livalo inavomerezedwa kuti igwiritsidwe ntchito ku United States ndi Food and Drug Administration (FDA) mu August wa 2009. Asanavomerezedwe ku US, pitavastatin inalipo kuti igwiritsidwe ntchito m'mayiko ena zaka zisanu zapitazo.

Kodi Livalo Imagwira Ntchito Bwanji?

Livalo imateteza tizilombo toyambitsa matenda otchedwa 3-hydroxy-3methylglutaryl coenzyme A (HMG CoA) reductase, yomwe ndi mapuloteni ofunikira omwe amafunika kuti apange cholesterol mu thupi.

Izi zimachepetsa cholesterol, LDL, ndi cholesterol cha VLDL mu thupi.

Kodi Livalo Iyenera Kutengedwa Bwanji?

Livalo ilipo papepala ndipo ikhoza kutengedwa popanda chakudya kamodzi patsiku, monga mwadongosolo ndi wothandizira zaumoyo wanu. Mlingo wa Livalo sayenera kupitirira 4 mg pa tsiku. Livalo iyenera kutengedwa pamodzi ndi zakudya kuti muchepetse cholesterol ndi triglycerides.

Livalo kawirikawiri imafotokozedwa ngati kusintha kwa moyo wanu kapena mankhwala ena sikuchepetsa kwambiri lipids yanu.

Muyenera kuonetsetsa kuti mukupita kumsonkhano wanu nthawi zonse kuchokera pamene akufunikira kuyang'anira miyezo yanu ya lipid, komanso magawo ena, pamene mukumwa mankhwalawa.

Ndani Asamalandire Livalo?

Ngati muli ndi zina mwazochiza zomwe zili pansipa, musamalandire Livalo. PAMASO awa, wothandizira zaumoyo wanu akhoza kukupatsani mankhwala osiyana kuti muchepetse lipids yanu:

• Zovuta kwa Livalo . Ngati mwapita kale ku Livalo kapena zowonjezera zake, musamamwe mankhwalawa.
• Matenda a chiwindi . Ngati muli ndi matenda a chiwindi kapena mapulaneti osakanizidwa a chiwindi, Livalo sayenera kutengedwa.
• Mimba. Buku la Livalo limagwiritsidwa ntchito ngati Mkwati wa Mamuna X. Bukuli lawonetsedwa kuti lidutse msempha wa makoswe ndipo pakhala pali malipoti okhudza kusokonekera kwa amayi komanso zovuta za mwana m'maphunziro a zinyama. Kuonjezera apo, izi zanenedwa ndi amayi apakati omwe akugwiritsa ntchito mankhwala ovomerezeka. Ngati mukukonzekera kutenga mimba kapena muli ndi pakati ndipo mutenga Livalo, wothandizira zaumoyo wanu adzayesa phindu la kumwa mankhwala pa thanzi lanu komanso mavuto omwe angakhalepo kwa mwana wanu.

• Nursing. Livalo yasonyezedwa kuti iwolowe mu chifuwa. Sikudziwika kuti zotsatirazi zingakhale zotani pa mwana wanu.
• Kuwongolera Cyclosporine. Mankhwalawa akhoza kuonjezera mabuku a Livalo m'thupi, zomwe zingayambitse mankhwala owopsa m'thupi. Wopanga amalimbikitsa kuti ngati mutenga Livalo, simuyenera kutenga cyclosporine.

Kodi Ndi Zinthu Ziti Zomwe Ziyenera Kuyang'aniridwa Pogwiritsa Ntchito Mabuku?

Ngati mutenga Livalo, wothandizira zaumoyo wanu angafunike kuyang'anitsitsa bwino ngati muli ndi matenda ena omwe angapangitse mankhwalawa. Ngati muli ndi zifukwa izi m'munsizi, wothandizira zaumoyo wanu angasankhe kukuyambitsani pa Livalo pamlingo wochepa, ndipo akuyenera kukuyang'anani kuti mudziwe ngati kutenga Livalo kungakhale koopsa kwa inu.

Mavuto awa ndi awa:

• Matenda a michere a chiwindi. Pofufuza, Livalo inachulukitsa mavitamini a chiwindi a aspartate aminotransferase (AST) ndi alanine aminotransferase (ALT). Ngakhale kuti nthawi zambiri kuwonjezeka kumeneku ndi kwa kanthaŵi kochepa, wothandizira zaumoyo wanu adzawunika mawindo awa kuti atsimikizire kuti mavitamini anu a chiwindi sali okwera kuti akhale oopsa.
• Matenda a impso. Ngati muli ndi matenda a impso ochepa kapena ovuta, wothandizira zaumoyo wanu angayambe kulandira mlingo wotsika kwambiri wa Livalo ndikuwunika thanzi lanu panthawi ya mankhwala.
• Maseŵera okwera magazi m'magazi. Kafukufuku wasonyeza kuti Livalo akhoza kuonjezera hemoglobini A1C ndi kudya msinkhu wa shuga. Ngati muli ndi shuga, wothandizira zaumoyo wanu akhoza kuyang'anira zigawo izi m'magazi anu ndi kusintha mlingo wanu wa Livalo.

Mitundu Yotani Yotsalira Idzalembedwa Chifukwa Chake?

Zotsatira zofala kwambiri zimaphatikizapo ululu wammbuyo, mavuto a m'mimba (monga kudzimbidwa kapena kutsekula m'mimba), kupweteka kwa minofu, ndi ululu pamapeto. Zotsatira zina zochepa zomwe zimachitikapo zambiri zimaphatikizapo kupweteka mutu komanso kupweteka. Ngati mukukumana ndi zotsatira zina kuchokera ku kutenga Livalo yomwe imakhala yotalika kapena yovutitsa, muyenera kulola wothandizira zaumoyo wanu kudziwa.

Mofanana ndi ma statins ena, zotsatira zosawerengeka - rhabdomyolysis - zikhoza kuchitika mwa anthu omwe amatenga Livalo. Zizindikiro za rhabdomyolysis zimaphatikizapo minofu yofooka ndi yofooka, komanso mkodzo wa mtundu wa soda. Zowopsa zowonjezera zotsatirazi zikhoza kuchitika ngati mutenga mankhwala ena, zaka zambiri, ndi matenda ena. Ngati mukumva zizindikiro za rhabdomyolysis, muyenera kumudziwitsa mwamsanga wothandizira zaumoyo wanu.

Kodi pali mankhwala omwe angagwirizane ndi Livalo?

Mankhwala otsatirawa angagwirizane ndi Livalo, kuwonjezera mwayi wa zovuta (makamaka myopathy). Kupatula mankhwala ochepetsa mafuta m'thupi, omwe ali pansipa, mankhwalawa akhoza kuonjezera mabuku a Livalo m'thupi lanu.

• Mankhwala osokoneza bongo wa cholesterol ( nicotinic acid , fibrates)
• Rifampin
• Erythromycin
• Colchicine

Iyi si mndandanda wathunthu. Muyenera kulola wothandizira zaumoyo wanu kudziwa za mankhwala onse - kuphatikizapo mankhwala osokoneza bongo komanso mankhwala osokoneza bongo - zomwe mukuzitenga mutatenga Livalo. Izi zidzakuthandizani osowa chithandizo chamankhwala kuti azikuyang'anirani momwe mungagwiritsire ntchito mankhwala osokoneza bongo mukamamwa mankhwala. Ngati mukuyenera kutenga mankhwala omwe atchulidwa pamwambapa, wothandizira zaumoyo wanu angafunikire kusintha mlingo wanu, kuyang'anirani bwino kwambiri zotsatira zake, kapena kusiya mankhwala ena.

Mfundo Yofunika Kwambiri

Livalo ndi mankhwala omwe amatsitsimula kwambiri omwe amavomerezedwa ku United States. Mu maphunziro ena, zikuwoneka kuti ndi zothandiza kwambiri pakuchepetsa lipid mu mlingo wofanana wa simvastatin ndi atorvastatin. Livalo ikuwoneka kuti ikudutsa njira ina m'chiwindi kuti ikhale yowonongeka poyerekeza ndi zina za statins, zomwe zimachepetsera chiwerengero cha mankhwala omwe amachitira anthu omwe amatenga mankhwalawa. Komabe, Livalo siinaphunzire mozama kwambiri popewera imfa kapena kulemala chifukwa cha matenda a mtima.

_Zotsatira

_{Duggan ST. Pitavastatin: kubwereza kwa ntchito yake poyang'anira hypercholesterolemia kapena osakaniza matenda a dyslipidemia. Mankhwala osokoneza bongo 2012; 72: 565-584.}

_{Lonse L, Budinski D, Hounslow N, et al. Kuyerekezera pitavastatin ndi simvastatin mu primary hypercholesterolaemia kapena kuphatikizapo dyslipidaemia. Curr Med Res & Opin 2009; 25: 2755-64.}

_{Budinski D, Arneson V, Hounslow N, et al. Pitavastatin poyerekeza ndi atorvastatin mu primary hypercholesterolemia kapena kuphatikizapo matenda ochepetsa matenda a dyslipidemia. Clin Lipidol 2009; 4: 291-302}

_{LIVALO [phukusi]. Cincinnati, OH: Kowa Pharmaceuticals America, 10/2013}

_{Micromedex 2.0. Truven Health Analytics, Inc. Greenwood Village, CO. Kupezeka pa: http://www.micromedexsolutions.com. Inapezeka pa February 10, 2016}