Kodi mankhwala otchedwa Monoclonal Antibody Therapy ndi otani?

Phunzirani Zowona za mankhwala a Monoclonal Antibody

Mankhwala otchedwa Monoclonal antibody therapy ndi omwe amathandizidwa ndi khansa . Nthawi zina amatchedwa immunotherapy. Ngakhale kuti opaleshoni , mankhwala a chemotherapy , ndi mankhwala opatsirana pogwiritsa ntchito mankhwalawa amakhalabe njira zofunika kwambiri zothandizira khansa ya coloni, mankhwala omwe amachititsa kuti mankhwalawa asagwiritsidwe ntchito. Matenda ambiri omwe amachititsa kuti tizilombo toyambitsa matenda tizilombo timene timakhala ndi khansa ndi Bevacizumab (Avastin), Cetuximab (Erbitux), ndi Panitumumab (Vectibix).

Kodi ma antibodies a Monoclonal ndi otani?

Mankhwala a monoclonal ndi mapuloteni omwe amapangidwa mu labotale. Mapuloteniwa amapangidwa kuti agwirizane ndi malo omwe ali pamwamba pa maselo a khansa ndipo amalephera kukula ndi kufalikira. Mankhwala a monoclonal ali ofanana ndi ma antibodies omwe thupi lanu limapanga mwachibadwa mukakhala ndi mabakiteriya kapena mavairasi, monga chimfine kapena chimfine.

Kodi Mankhwala a Monoclonal Akugwira Ntchito Motani?

Maselo m'thupi lathu, kuphatikizapo maselo a khansa, ali ndi malo omwe ali pamwamba pawo amatchedwa receptors. Zipangizozi zimathandiza kuchepetsa momwe maselo athu amakulira, amasiya kukula, kapena amachita chilichonse chimene maselo amachita. Ngati puloteni yoyenera ikubwera ndikugwirizanitsa (kumangirira) kwa cholandira mu selo, izi zimayambitsa selo kuti iyankhule.

Njira yabwino yoganizira za mapuloteni ndi mapuloteni awo omangirira ndi kuganizira za lock ndi key. Chikhiro sichidzatsegule popanda chinsinsi cholondola. Mofananamo, cholandira sichidzayambitsa selo kukula, kugawa, kapena kuchitapo kanthu pokhapokha "chinsinsi" choyenera kwa cholandiracho chikugwirizana.

Ndipo ma antibodies a monoclonal ndi "mafungulo" omwe apangidwa kuti agwirizane ndi mapulogalamu a khansa.

Zitsanzo za Mankhwala Omwe Amachiza Monoclonal

Epidermal Grow factor receptors (EGFRs) ndi chitsanzo chimodzi cha mapuloteni omwe amadzimadzi amodzi omwe amawunikira. EGFR alipo pa maselo abwino ndi maselo a khansa, koma ndi maselo a khansa, izi zimakhala zachilendo.

Pakhoza kukhala EGFR zambiri kapena zikhoza kuwonongeka kapena kusinthidwa (kusinthidwa) mwa njira yomwe imawalola kuti ayankhe mozama pa zizindikiro zowonjezera. Izi zimapangitsa maselo a khansa kukula msanga kapena kukula m'malo omwe sayenera kukula.

Mankhwala otchedwa antioclonal anti-inflammatory Cetuximab (Erbitux) ndi Panitumumab (Vectibix) amagwirizana kwambiri ndi EGFR yomwe imapezeka pa maselo a khansa. Akamamatirana ndi EGFRs, amalepheretsa zizindikiro zomwe zimapangitsa kuti thupi lanu lizikhala ndi khansa. Izi zimachepetsa kapena kuchepetsa kukula kwa khansa.

Kuganizira za lolo ndi kufanana kwachinsinsi, mungaganizire kuti Cetuximab ndi Panitumumab amagwira ntchito ngati wina atakaniza chingamu. Mfungulo sungakhoze kulowa ndipo khomo silikhoza kutsegulidwa chifukwa khansa yamatenda ya receptor "yayamba" ndi ma antibodies a monoclonal. Izi zikutanthauza kuti maselo a khansa salandira zowonjezera zomwe zikufunika kuti apitirize kukula ndikufalitsa.

Matenda a Monoclonal Conjugated

Kuwonjezera pa kungowonjezera ntchito za selo yotupa, maselo a monoclonal akhoza kugwirizanitsidwa ndi mankhwala a chemotherapy kapena radioactive (radioimmunotherapy) kotero iwo amatenga njira yothetsera kansa osati maselo oyenera. Izi zikugwiritsidwa ntchito ndi mitundu ina ya lymphoma ndi khansa ya m'mawere ndi mankhwala angathe kukhalapo kuti athetse mitundu ina ya khansa.

Kodi zotsatira za mankhwala a Monoclonal Antibody Therapy?

Kwa anthu ambiri, zotsatira za mankhwala a monoclonal antibody therapy ndi ovuta kuposa chemotherapy ndipo zimafanana ndi zomwe zimachitika. Zina mwa zotsatira zofala kwambiri za mankhwala a monoclonal antibody ndi awa:

• Kuphulika khungu
• Kuyamwa khungu kapena ming'oma
• Zizindikiro zofanana ndi ziwombankhanga monga fever, chills, minofu yakuda, kutopa, ndi kupweteka mutu
• Kutsekula m'mimba
• Nsowa ndi kusanza
• Kuthamanga kwa magazi

Anthu ena amachitanso chidwi kwambiri ndi mankhwala otchedwa monoclonal antibody therapy. Zotsatira zowopsa kwambiri zomwe zingayambitse dokotala kuti asiye mankhwalawa amodzi ndi awa:

• Magazi otsika kwambiri amawerengera

• Mavuto a mtima kuphatikizapo kupweteka mtima kwa mtima, kulephera kwa mtima, komanso kuopsa kwa matenda a mtima
• Mankhwala otsika a magnesium, potassium, kapena calcium m'magazi anu, omwe angayambitse matenda aakulu
• Ziphuphu zazikulu za khungu zomwe zimayambitsa matenda
• Matenda odzola
• Kuchitapo kanthu mwamsanga ku kulowetsedwa kuphatikizapo mpweya wochepa, kupuma, mantha, kutaya, chizungulire, kuwona masomphenya, kunyoza, kapena kupweteka pachifuwa kapena kupanikizika

Mwamwayi, pakakhala zochitika zowopsa, nthawi zambiri zimachitika mwamsanga, pamene mukulandira mankhwala kuchipatala chanu cha chisamaliro. Izi zikutanthauza kuti dokotala wanu ndi namwino adzakuyang'anirani ndipo adzatha kuika kulowetsedwa ngati kuli kofunikira ndikukupatsani chithandizo chamankhwala mwamsanga.

Kodi Ndingatani Kuti Ndizigwiritsa Ntchito Mankhwala Ochepetsa Matenda a Monoclonal?

Zinthu ziwiri zofunika kwambiri zomwe mungachite pofuna kuthetsa mavuto a monoclonal antibody therapy ndi:

1. Tengani mankhwala anu onse monga momwe mwafunira, chifukwa ndi kosavuta kupewa zovulaza kusiyana ndi kuwachitira iwo akangochitika.
2. Pitirizani kulankhulana momasuka ndi gulu lanu lachipatala. Chimene chimagwirira ntchito kuthetsa zotsatira za munthu mmodzi sikungagwire ntchito kwa inu. Lankhulani ndi dokotala wanu kapena namwino za njira zomwe zingakuthandizeni kuti muthe kuchipatala ndi zotsatira zochepa.

Musavomereze kumverera koteroko ndi gawo lachibadwa la mankhwala opatsirana khansa. Pakhoza kukhala njira yoti gulu lanu lachipatala liziyenda bwino. Ngati mukufuna thandizo, funsani. Ndipo nthawi zonse, ngati muli ndi mafunso okhudza zotsatirapo, funsani gulu lanu lachipatala nthawi yomweyo.

_Zotsatira

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https://medlineplus.gov/druginfo/meds/a607001.html}

_{Medline Plus. Inuximab Injection.
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_{Medline Plus. Kupweteka kwa panitumumab.
https://medlineplus.gov/druginfo/meds/a607066.html}

_{Patel DK. Kugwiritsa ntchito chipatala chotsutsana ndi epidermal kukula factor receptor monoclonal antibodies m'thupi lachilendo lakuda. Pharmacotherapy 2008 28: 31S-41S.}

_{Ramos FJ, Macarulla T, Capdevila J, Elez E, Tabernero J. Kumvetsetsa ntchito yowonongeka ya K-ras chifukwa cha epidermal kukula zomwe zimalandira chithandizo chamankhwala mu khansa yoyipa. Clin Colorectal Cancer 2008 7: S52-S57.}

_{American Cancer Society. Matenda a Monoclonal. Kupezeka: Dec. 4, 2015.
http://www.cancer.org/treatment/treatmentsandsideeffects/treatmenttypes/immunotherapy/immunotherapy-monoclonal-antibodies}