Berberine ndi mankhwala omwe amapezeka m'mitima yambiri, monga makungwa, mizu, rhizomes ya zomera zomwe zimapezeka padziko lonse lapansi, komanso zowonjezerapo m'masitolo odyetsera thanzi. Madalitso abwino a Berberine akhala akudziwika kwa zaka mazana ambiri ndipo akhala akugwiritsidwa ntchito pochiza matenda osiyanasiyana ku India ndi ku China, kuchokera ku shuga kupita ku matenda.
Chifukwa cha mtundu wake wachikasu, idagwiritsidwanso ntchito ndi zikhalidwe zina kuti zive nsalu.
M'zaka zaposachedwapa, berberine yodzipatula kuchokera ku zomera zina iphunzitsanso pochizira kutupa, khansa, nyamakazi ndi mtima wosalimba. Palinso umboni wina umene umasonyeza kuti berberine ikhoza kukhala yothandiza kuchepetsa mafuta a kolesterol ndi triglyceride.
Maphunziro Aposachedwapa Onetsani Lonjezo
Ngakhale pali maphunziro ochepa omwe amafufuza zotsatira za berberine pamagulu a lipid , ambiri mwa maphunzirowa ankachitidwa mu hamsters ndi mbewa. Berberine mu maphunzirowa adasonkhanitsidwa kuchokera ku zitsamba zosiyanasiyana, kuphatikizapo mizu ya goldenseal ndi Huanglian.
Pa maphunziro a nyama, berberine imaperekedwa kulikonse pakati pa 100 ndi 250 mg / makilogalamu a thupi tsiku lililonse. Berberine inkaoneka kuti yayamba kuchepetsa thupi lonse mpaka kufika 31 peresenti. Kuonjezerapo, magulu a triglyceride adachepetsedwa ndi pafupifupi 32% ndipo maola a LDL a m'thupi anali otsika ndi 25%.
Ngakhale HDL inayesedwa, berberine sanawoneke bwino.
Kafukufuku wochepa chabe wa anthu omwe adafufuza ka berberine anawonekera kuti awonetsere maphunziro omwe amapangidwa ndi nyama. Berberine 500 mg ankaperekedwa kwa anthu omwe ali ndi mitsempha yapamwamba ya cholesterol kawiri kapena katatu tsiku lililonse kwa miyezi itatu. Zotsatira zake, chiwerengero chonse cha mafuta m'thupi chinatsika mpaka 29%.
Mavitamini a Triglyceride ndi LDL amachepetsanso chifukwa cha kudya kwa berberine. Mwachitsanzo, maola a m'thupi la LDL adachepetsedwa ndi pafupifupi 21%, pamene magulu a triglyceride adatsitsidwa paliponse pakati pa 22 ndi 35%. Maulendo a HDL, sizinasinthe kwambiri ndi kuwonjezera kwa berberine.
Kodi Berberine Lower Cholesterol Imatani?
Ngakhale kuti njira yomwe berberine imagwirira ntchito pochepetsa cholesterol sichidziwikiratu, asayansi ali ndi mfundo zingapo pazifukwa zomwe zaposachedwapa. Zikuganiza kuti berberine ikhoza kuonjezera chiwerengero cha amalandila a LDL pachiwindi, chomwe chingathandize kuonjezera kutsegula kwa cholesterol cha LDL m'thupi. Berberine amawonekeranso kuti akugwiritsa ntchito njira zozindikiritsira njira zopangira mafuta m'thupi. Berberine amasonyezanso kuti amachitanso chimodzimodzi ndi tizilombo toyambitsa matenda mwa kuletsa kutsekemera kwa lipids kuchokera m'mimba yaing'ono.
Kodi Muyenera Kutenga Berberine Kuti Muchepetse Cholesterol?
Kafukufuku wofufuza ntchito ya berberine kuti adzichepetse cholesterol akuwoneka kuti akulonjeza, komabe kafukufuku wina amafunika kuti asanatengedwe monga wothandizira kuchepetsa cholesterol.
Berberine sayenera kuperekedwa kwa makanda, chifukwa akhoza kuwononga ubongo, kapena kwa amayi omwe ali ndi pakati ndi amayi omwe akuyamwitsa (izo zingawononge mwana kapena mwana wakhanda).
Berberine palokha ndi zovuta kupeza ngati chowonjezera kuti mutenge pansi lipids yanu. Komabe, zambiri zowonjezera zitsamba ndi zomera zimapezeka malonda omwe ali ndi berberine yambiri, kuphatikizapo:
- Mizu ya Goldenseal ( Hydrastis canadensis L )
- Mizu ya mphesa ya ku Ohio ( Berberis aquifolium )
- Barberry ( Berberis vulgaris )
- Huanglian ( Coptis chiensis )
Mitengo ya berberine imasiyanasiyana pakati pa zomera zonse. Mwachitsanzo, goldenseal ikhoza kukhala ndipakati pa 1% ndi 6% ya berberine. Choncho, mungafunikire kufufuza lemba loonjezerapo kuti muzindikire ku Berberine, m'malo mwa zitsamba zonse, piritsi lililonse.
Kuti muone zotsatira za cholesterol yomwe imatchulidwa mwa maphunziro aumunthu, muyenera kudya 500 mg ya berberine awiri kapena katatu patsiku.
Ngakhale kuti mukupezeka mosavuta, muyenera kufunsa wothandizira zaumoyo wanu musanamveke berberine - kapena mankhwala enaake owonjezera omwe ali ndi mankhwalawa - kuti muchepetse mankhwala. Zotsatira zoyipa zogwiritsidwa ntchito ndi mankhwala omwe ali ndi berberine amakhala ndi kupweteka mutu, kumimba mimba, ndi mseru. Zotsatira za zitsambazi pazochitika zina za thanzi sizidziwikiratu, ndipo sizidziwika ngati mankhwala owonjezera a berberine angagwirane ntchito ndi mankhwala ena alionse omwe mukuwatenga.
Zotsatira:
Abidi P, Chen W, Kraemer FB, Liu J. Chithandizo cha mankhwala goldenseal ndi lachilengedwe LDL-kuchepetsa wothandizira ali ndi zigawo zambiri za bioactive ndi njira zatsopano zothandizira. J Lipid wa 2006; 47: 2134-2147.
Cicero AFG, Erkek S. Berberine: zotsatira zamaganizo ndi zamtima m'mayesero owonetsetsa ndi odwala. Zakudya Zakudya Zakudya Zakudya Zam'madzi 2009; 1: 1-10
Chikhalidwe Chachilengedwe. (2015). Berberine [Monograph].
Pirillo A, Catapano AL. Berberine, chomera cha alkaloid chokhala ndi lipid ndi glucose-kutsika katundu: kuchokera mu vitro umboni kupita kuchipatala. Atherosclerosis 2015; 243: 449-461.