Juxtapid (limitapide) ndi mankhwala omwe amagwiritsidwa ntchito kwambiri pochepetsa mafuta okwanira m'thupi, LDL, ndi ma apolipoprotein B - kuphatikizapo zakudya ndi zina zothandizira - mwa anthu omwe ali ndi vuto lachidziwitso la a hypercholesterolemia , lomwe ndi losabadwa, limene limayambitsa kwambiri LDL cholesterol ndi mitsempha ya mtima matenda kumayambiriro kwa moyo. Juxtapid inavomerezedwa kuti igwiritsidwe ntchito ku United States ndi Food and Drug Administration mu December 2012.
Juxtapid yakhala ikuphunzitsidwa bwino mwa anthu omwe amapezeka kuti ali ndi vuto lachilendo la amayi omwe ali ndi HIV komanso osati ndi anthu omwe ali ndi vuto linalake lomwe limayambitsa ma cholesterol. Mu kafukufuku wina, Juxtapid 5 mpaka 60 mg tsiku lililonse ankaperekedwa kwa anthu omwe kale amatenga mankhwala ena ochepetsa mafuta a kolesterolini chifukwa cha miyeso yawo yapamwamba ya LDL. Kafukufukuyu adawonetsa kuti kuonjezera Juxtapid ku mitundu ina yothandizira inachepetsa ma LDL ndi 50%. Mabala a Triglyceride, ma apolipoprotein B, VLDL ndi mafuta onse a kolesteroloni amachepetsanso kwambiri.
Kafukufuku wina adafufuzanso kuti anthu omwe ali ndi matenda ofanana ndi Juxtapid okhawo amalephera kuchepetsa makasitomala. Pamapeto pa phunziroli, pa mlingo wa 1 mg / kg / tsiku, ma level LDL ndi ma apolipoprotein B amatsitsidwa ndi pafupifupi 50%.
Ngakhale kuti zofukufukuzi zathandiza kwambiri cholesterol mu odwalawa, awonetsanso Juxtapid zingayambitse mavuto akuluakulu - kuphatikizapo m'mimba komanso zotsatira za matenda a chiwindi.
Kuonjezerapo, popeza maphunzirowa atha kwa masabata 78, maphunziro ena akuchitika panopa kuti adziwe kuti chitetezo cha Juxtapid chidzakhalapo nthawi yaitali.
Kodi Zimagwira Ntchito Bwanji?
Juxtapid imachepetsa cholesterol cha LDL potseka puloteni ya microsomal triglyceride (MTTP), molekyu m'thupi lomwe limalepheretsa VLDL ndi ma chylomicrons kupanga chiwindi.
Chifukwa chakuti VLDL isandulika LDL, izi zidzachepetsanso ma LDL m'magazi.
Kodi Ndizitenga Bwanji Mankhwalawa?
Juxtapid iyenera kutengedwa pakamwa, ndi madzi, pamimba yopanda kanthu. Akuti mankhwalawa amatengedwa osachepera maola awiri atatha kudya. Wopereka chithandizo chaumoyo wanu adzayesa kuyesa magazi - kuphatikizapo kuyesa michere ya chiwindi ndi ma cholesterol - musanatchule Juxtapid kwa inu.
Zotsatira Zowonongeka Zotheka
Mavitamini amphamvu a chiwindi ndi kuphatikiza mafuta m'chiwindi zakhudzana kwambiri ndi kutenga Juxtapid. Choncho, dokotala wanu adzafunika kuyesa kafukufuku wamagazi kuti azindikire kuchuluka kwa mavitamini a chiwindi, kuphatikizapo alanine aminotransferase, aspartate aminotransferase, ndi alkaline phosphatase, kuwonjezera pa kuyang'anira makilogalamu anu a cholesterol. Chifukwa cha zotsatira zake, Juxtapid ali ndi "warning box" ya hepatotoxicity, yomwe ndi chenjezo lamphamvu lochokera ku Food and Drug Administration chifukwa chakuti mbali iyi yakhala ikudziwika pofufuza kufufuza kwa mankhwalawa. Chifukwa cha kuopsa kwa juxtapid kuli pachiwindi, dokotala wanu adzakulembetsani mu pulogalamu yokhazikika, yotchedwa pulogalamu ya Juxtapid REMS.
Pansi pa pulojekitiyi, ndi madokotala ndi apamayi okha omwe amatsimikiziridwa kuti amvetse mankhwalawo ndi zoopsa zake akhoza kupereka ndikugawa Juxtapid.
Matenda a m'mimba, monga kunyoza, kusanza, kupweteka kwa mtima, kutsekula m'mimba, kudzimbidwa ndi kupweteka kwa m'mimba, akhala ndi zotsatira zoyipa kwambiri mwa anthu omwe amatenga Juxtapid. Anthu ena adanenanso kuti akudwala, amamva kupweteka pachifuwa, ndi kutopa pamene akutenga mankhwala.
Ndani Sayenera Kuzitenga?
Pakalipano, Juxtapid yakhala ikuwerengedwa mwa anthu omwe amapezeka kuti ali ndi vuto lachilombo chowopsa chifukwa cha chiopsezo chachikulu cha matenda a mtima.
Choncho, sizikudziwika ngati juxtapid imakhala yogwira mtima kwa anthu omwe ali ndi matenda ena omwe amachititsa kuti thupi lizizizira kwambiri. Anthu ena omwe ayenera kufunsa dokotala wawo asanatenge Juxtapid ndi awa:
- Anthu omwe ali ndi matenda a chiwindi - Juxtapid amatha kuonjezera mavitamini a chiwindi monga transaminase ndi kuwonjezera mafuta a chiwindi.
- Anthu omwe ali ndi matenda a impso - Magulu a Juxtapid amatha kuwonjezeka m'magazi.
- Azimayi omwe ali ndi mimba - Juxtapid yasonyezedwa kuti ndi yoopsa kwa mwana wosabadwa pa maphunziro a nyama. Akazi omwe angathe kubereka ayenera kuyesedwa koyambitsa mimba asanayambe Juxtapid ndipo ayenera kugwiritsa ntchito njira zina zothandizira kubereka komanso kutenga mankhwala.
- Azimayi omwe akuyamwitsa - Juxtapid sanaphunzire kwambiri. Chifukwa cha kukula kwa ntchentche mu mbewa, ndibwino kuti namwino - kapena mankhwala - ayenera kusiya.
Kuyanjana kwa Mankhwala
Palinso mankhwala ena omwe angagwirizane ndi Juxtapid, zomwe zingachititse kuti juxtapid kapena mankhwala ena adziwononge thupi. Zotsatirazi ndi mndandanda wa mankhwala omwe angagwirizane ndi Juxtapid kotero ngati mutenga mankhwala amodzi kapena ambiri, muyenera kufunsa dokotala wanu.
- Mavitamini ndi zakudya monga mavitamini A, D, E, ndi K, ndi omega-3 fatty acids , sangathenso kutengeka pamene akutenga Juxtapid.
- Juxtapid ingapangitse magazi ochulukirapo magazi ena, monga warfarin, m'magazi. Izi zikhoza kukuchititsani kuti mumve magazi kapena kuvulaza mosavuta.
- Ngati mukugwiritsa ntchito atorvastatin kapena simvastatin, Juxtapid ingawonjezere magazi mwa mankhwalawa. Dokotala wanu angasinthe mankhwala anu a mankhwala pamene akutenga Juxtapid.
Chifukwa cha njira yomwe juxtapid imagwiritsira ntchito thupi, imatha kuwonjezera mankhwala ena omwe mumatenga - chifukwa chake mumapanga mankhwala oopsa kwambiri. Izi zimaphatikizapo mankhwala ena osokoneza bongo, antibiotic, mankhwala osokoneza bongo, mankhwala a magazi, mankhwala omwe amagwiritsidwa ntchito pofuna kupweteka mtima, komanso mankhwala (monga goldenseal, mphesa). Choncho, muyenera kuonetsetsa kuti odwala onse akudziŵa mankhwala alionse amene mukuwatenga kuti athe kuwonetsa mokwanira zoyenera kuchita ndi Juxtapid. Dokotala wanu angasankhe kusintha mlingo wanu wa Juxtapid kapena mankhwala ena ngati kugwirizana kukupezeka.
Pansi
Juxtapid ndi mankhwala ochepetsa kupatsa kwa mafuta m'thupi, omwe amaletsa MTTP. Ngakhale kuti kafukufuku wasonyeza kuti Juxtapid imaphatikizapo mphamvu zina zochepetsa LDL mwa anthu omwe ali ndi vuto lodziwika bwino la hypercholesterolemia, pali zinthu zambiri zotetezedwa ndi Juxtapid ndipo ntchito yake yakhala yongoperekedwa ku matendawa chifukwa cha zoopsazi. Dokotala wanu adzayesa ubwino wokatenga Juxtapid, komanso kuopsa kwa zotsatirapo ndi mankhwala. Chifukwa chakuti zotsatira za nthawi yaitali zotenga juxtapid sizidziwika - kuphatikizapo kuthekera kwake kuteteza matenda a mtima - pali maphunziro omwe akupitilira kuti ayese izi.
Zotsatira:
Cuchel M, Meagher EA, Theron HD, et al. Kuchita bwino ndi chitetezo cha microsomal triglyceride transfert protein inhibitor kwa odwala omwe ali ndi vuto lachilendo la azimayi la hypercholesterolemia: dzanja limodzi, lotseguka, phunziro lachitatu. Lancet 2013; 381 (9860): 40-6.
Cuchel M, Bloedon LT, Szapary PO, et al. Kuletsa microsomal triglyceride kupititsa mapuloteni m'mabanja a hypercholesterolemia. N Eng J Med 2007; 356: 148-156.
Juxtapid ® (pamitapide) Package Insert. Aegerion Pharmaceuticals. March 2016.