Pakhoza kukhala njira yothetsera kuphulika kwanu kosatha ndi khungu
Dermatitis , yomwe imadziwikanso kuti eczema, ndi yodwala, yodwala matenda a khungu omwe amachititsa khungu lofiira, losalala, losakanizika, komanso nthawi zina. Nthawi zambiri zimayambira mu ubwana ndipo anthu ena amatha kupitirizabe kukhala akuluakulu. Ndipotu malinga ndi magazini ya American Academy of Dermatology, pafupifupi munthu mmodzi kapena atatu pa anthu 100 alionse padziko lonse ali ndi dermatitis ya atopic.
Cholinga chenicheni cha atopic dermatitis akadakali kukangana ndi kuphunzira, koma mwachidziwikire chimaphatikizapo kusinthasintha kovuta pakati pa majini a munthu, chitetezo chawo cha mthupi, ndi kuwonongeka kwa matenda a epidermis-kutsika kwa khungu la munthu.
Dermatitis yapamwamba imatha kusamalidwa ndi:
- Kusamala bwino khungu , kuphatikizapo chinyezi.
- Kuchotsedwa kwa zokopa ndi zinthu zovuta.
- Mankhwala amagwiritsidwa ntchito pakhungu, ngati mankhwala a steroid odzola ndi mafuta odzola.
Komabe, kwa ena achikulire omwe ali ndi chiwopsezo choopsa kwambiri, matenda awo samasintha ndi mankhwala achizolowezi (kapena sangathe kutenga mankhwalawa), kotero kuti jekeseni wamagetsi ingafunike.
Dupixent (dupilumab) ndi mankhwala oyamba omwe amadwala mu FDA omwe amavomerezedwa kuti azitha kulandira chinyezi kwambiri kwa akuluakulu. Ili ndi jekeseni milungu iwiri iliyonse mu ntchafu kapena m'munsi m'mimba mwa mafuta omwe ali pansi pa khungu-izi zimatchedwa jekeseni ya subcutaneous.
Nkhani yabwino ndi yakuti dokotala wanu kapena namwino angakuphunzitseni inu kapena wokondedwa wanu kuti mupereke jekeseni, kotero mutha kuchichita chitonthozo cha nyumba yanu. Ndibwino kudziwa kuti mankhwalawa angagwiritsidwe ntchito pogwiritsidwa ntchito ndi mankhwala otchedwa topical steroid, kapena angagwiritsidwe ntchito okha.
Momwe Dupixent (dupilumab) Amagwirira Ntchito
Dupixent (dupilumab) ndi mankhwala a biologic, omwe amatanthauza kuti zimagwira thupi lonse kusintha momwe thupi lanu limagwirira ntchito.
Ndi munthu wotchedwa monoclonal antibody-mtundu wa anti-antibody wotengedwa mu labotale.
Kamodzi kamene kanakanizidwa ndi kulowa m'magazi, imamangirira malo enaake omwe amatha kuteteza mapuloteni awiri (interleukin-4 ndi interleukin-13). Mapuloteniwa amadziwika kuti amathandiza kwambiri kupanga mapangidwe a chilengedwe.
Zotsatira za Dupixent (dupilumab)
Kafukufuku wasonyeza osati kuchepa kwa thupi komanso kukula kwa ziwalo zazing'ono komanso kuchepetsa kukwatulidwa, zomwe zingakhale zofooketsa kwambiri kwa anthu okhala ndi dermatitis ya atopic. Kuonjezera apo, mu magawo awiri a masabata 16, mayesero amapezeka kuti amachepetsa zizindikiro za nkhawa komanso kupsinjika maganizo komanso kusintha moyo.
Kodi Pali Zotsatira Zowopsya Zomwe Mukuzizindikira?
Injectable ingayambitse kupweteka kwa khungu pa malo a jekeseni. Ngakhale kuti n'zosatheka, zingayambitsenso mavuto aakulu, komanso mavuto a maso monga diso lakuphwa, kuyang'ana maso, maso a pinki (wotchedwa conjunctivitis ), khungu la kutupa (lotchedwa blepharitis), kapena kutupa kwa cornea (yotchedwa keratitis). Zilonda pamlomo kapena pambali pa milomo ndi pakamwa ponse (zotchedwa oral herpes ) zanenedwa.
Ndikofunika kulankhulana ndi dokotala mwamsanga mukakumana ndi mavuto a masomphenya, ululu wa maso, kapena kukwiya kwamaso.
Ndikofunika kuleka kupereka mankhwala ndi kuchipatala ngati mukuwona zizindikiro zowoneka ngati ming'oma, kuthamanga kwa khungu kapena wopanda malungo, kutupa kwa mitsempha yam'mimba, kupweteka pamodzi, kukwatulidwa, kapena kumverera kwakukulu. Zoonadi, zomwe tatchula pamwamba sizomwe zingathe kuvulaza munthu, choncho onetsetsani kuti mukumana ndi dokotala ndi mavuto kapena nkhawa.
Pomalizira pake, anthu ena amapanga mankhwala osokoneza bongo, omwe amapezeka pamene thupi limapanga mapuloteni kuti achepetse kapena kutilepheretsa. Izi zikhoza kukayikidwa ngati munthu asiya kuyankha mankhwala, ndipo akhoza kutsimikiziridwa ndi kuyesa magazi.
Kodi Ndiyenera Kuuzanji Dokotala Wanga?
Lankhulani ndi dokotala wanu za matenda anu onse, makamaka ngati muli ndi vuto la maso, matenda opatsirana, kapena mphumu. Komanso, onetsetsani kuuza dokotala wanu ngati muli ndi mimba, akuyamwitsa, kapena mukuyenera kulandira katemera. Chifukwa cha zotsatira za chitetezo cha munthu, amalangizidwa kuti palibe amene amamwa mankhwalawa amalandira katemera uliwonse (mwachitsanzo, katemera wa chimfine kapena choster).
Ndikofunika kugawana ndi dokotala wanu mankhwala anu onse, kuphatikizapo mankhwala osokoneza bongo, mavitamini, kapena mavitamini.
Chithunzi chachikulu pano chiyenera kukonzedwa mukamachezera munthu wotsutsa. Pochita bwino ndikugawana mbiri yanu yachipatala ndi dokotala, amatha kudziwa ngati izi ndizo chithandizo chabwino kwa inu.
Mawu Ochokera
Atopic dermatitis yambiri imatha kuyambitsa mazenera ambiri a thupi pa thupi, zomwe zingakhale zomasuka komanso zakuthupi. Dupixent (dupilumab) imapereka mwayi kwa anthu achikulire omwe ali ndi matenda oopsa koma sanalandire chithandizo chomwe amayenera kuchipatala monga mankhwala opangira steroid ndi mafuta odzola. Kuonjezera apo, zikuwoneka kuti ndi zotetezeka, ngakhale kuti chiopsezo chowonjezeka cha vuto la maso chiyenera kudodometsedwa kwambiri.
Izi zikunenedwa, mankhwalawa si a aliyense, ndipo panthawi ino, amasungidwa kwa omwe alibe njira zina. Khalani pa bwalo monga momwe kafukufuku akupitilira kusinthika pa biologics yoyambitsa jekeseni.
> Zotsatira:
> American Academy of Dermatology. Dermatitis yapamwamba: Ndani Amapeza Ndi Zifukwa.
> Beck LA et al. Mankhwala a Dupilumab kwa akuluakulu omwe ali ochepa kwambiri mpaka aakulu atopic dermatitis. N Engl J Med . 2014 Jul 10, 371 (2): 130-9.
> Simpson EL et al. Mayesero awiri a Dupilumab ndi a placebo a atopic dermatitis. N Engl J Med . 2016 Dec 15; 375 (24): 2335-2348.
> Spergel JM. (February 2015). Kusamala kwa kutsutsa kwakukulu paopopitisitis (eczema). Mu: UpToDate, Dellavalle RP (Ed), UpToDate, Waltham, MA.
> Utsogoleri wa US Food and Drug Administration. (March 2017). Kufotokozera Kwathunthu : Dupixent .