DHEAS, kapena dehydroepiandrosterone sulphate, ndi mawonekedwe a hormone a androgenic DHEA omwe ali ndi molecule ya sulfate (atomu imodzi ya sulfure ndi 4 atomu ya oxygen) yomwe imayikidwapo. Pafupifupi onse a DHEA akuyenda m'magazi ali ngati mawonekedwe a DHEAS .
Magazi a DHEAS amawoneka kuti ali okwera kwambiri kwa amayi omwe ali ndi matenda a polycystic ovarian (PCOS). Madokotala adzayesa magawo a seramu (magazi) a steroid kuti athetse mavuto ena azachipatala omwe ali ndi zizindikiro zofanana ndi PCOS.
M'moyo wanu wonse
DHEAS imayendetsedwa ndi matenda a adrenal ndipo ndi mahomoni ambiri ozungulira steroid pakati pa anthu. Amasandulika kukhala estrogen kapena testosterone mu thupi.
Pamene adakali mu utero, DHEAS imabisika ndi mwana wosabadwa kwambiri. Pakangotha masabata angapo atabadwa, magulu amenewa amatha pafupifupi 80 peresenti, koma amaukanso posakhalitsa nthawi isanakwane, nthawi yotchedwa adrenarche.
Amayi achichepere, adrenarche oyambirira imalumikizidwa ku chiopsezo chowonjezeka cha PCOS. Pambuyo pa adrenarche, magulu a DHEAS akuwonjezeka, akuyendayenda ali ndi zaka 20, kenako akuchepa zaka makumi angapo zikubwerazi.
Kwa amayi, machitidwe apamwamba a DHEAS angayambitse zizindikiro za hyperandrogenism , chizindikiro chachikulu cha PCOS. Kutchulidwa kukwera kwa ma hormoni kungasonyeze kuti androgen imapanga ziwalo za adrenal.
Kuyesera Masitepe Anu
Pafupifupi 20 mpaka 30 peresenti ya amayi omwe ali ndi PCOS adakweza ma DHEAS. Pakati pa mankhwala anu a PCOS, dokotala wanu akhoza kulamula ntchito ya magazi kuti ayese DHEAS yanu ndi mahomoni ena.
Masamba achibadwa a DHEAS amasiyana ndi zaka komanso chikhalidwe. Kwa amayi, maseŵera omwe ali ndi zaka 18 ndi 19 amakhala ndi 145 mpaka 395 micrograms per deciliter (mcg / dL), asanatsike. Mu zaka za 20, ma DHEAS amakhala pakati pa 65 ndi 380 mcg.
Kwa akazi makumi atatu, makumi asanu ndi awiri (270) ndi 270 mcg / dL, omwe ali ndi masitepe apitirira 32 mpaka 240 mcg / dL mu 40s.
Maseŵera amasiyana kuyambira 26 mpaka 200 mcg / dL mu 50s, kuyambira 13 mpaka 130 mcg / dL mu 60s ndi 17 mpaka 90 mcg / dL mutatha zaka 69.
Popeza chiwerengero cha DHEAS chimafooka ndi msinkhu, amayi ena amatenga DHEA zowonjezera, zomwe zimatsimikiziridwa kuchepetsa zizindikiro za ukalamba, kupititsa patsogolo mphamvu ya mafupa, kuchepetsa kupanikizika ndi kupititsa patsogolo libido.
Komabe, amayi omwe ali ndi PCOS amatha kale kukweza mahomoni a androgenic ndi supplementation ndi DHEA sali kulangizidwa.
Mankhwala Angasinthe DHEAS Maseŵera
Mankhwala angapo amatha kusintha DHEAS mlingo wanu. Insulini , mankhwala opatsirana pakamwa , corticosteroids , mapulogalamu ena a m'mitsempha omwe amagwiritsa ntchito mankhwala (monga carbamazepine, clomipramine, imipramine, ndi phenytoin), mavitamini ambiri, mankhwala a dopaminergic (monga levodopa / dopamine ndi bromocriptine), mafuta a nsomba, ndi vitamini E angachepetse chiwerengero cha DHEAS.
Mankhwala omwe angapangitse ma DHEAS amakhala monga metformin, troglitazone, prolactin, danazol, calcium channel blockers, ndi nikotini.
Kusintha uku, komabe, sikokwanira mokwanira kuti kuthandizire kuchipatala kwa PCOS kapena kupanga chisokonezo pozindikira PCOS kapena zinthu zachiwiri.