Antihistamines amagwiritsidwa ntchito kwambiri mankhwala ochizira matenda a rhinitis , komanso mavuto ena azachipatala monga kusowa tulo, kunyoza ndi kusanza, matenda oyenda ndi chizungulire. Mankhwalawa amagwiritsidwanso ntchito panthawi yomwe ali ndi mimba, monga antihistamines ambiri ali ndi kachilombo ka B , komanso kuti antihistamines ambiri amapezeka pa-counter-a-counter (OTC) popanda mankhwala.
Choncho, ngakhale kuti nthawi zambiri zimatengedwa ngati "zotetezeka" panthawi yomwe ali ndi mimba, pali mayanjano angapo apakati pakati pa amayi omwe ali ndi pakati omwe amatenga antihistamines m'nthawi ya trimester yoyamba ndi zolekanitsa zobadwa.
Mabwenzi Okhoza Kukhalapo pakati pa Antihistamines ndi Matenda a Kubadwa
Mgwirizano pakati pa antihistamines womwe watengedwa m'kati mwa trimester yoyamba ya mimba ndi zina zolepheretsa kubadwa zikuphatikizapo:
- Diphenhydramine (Benadryl) : Cleft lip ndi cleft palate , neural tube ziphuphu, Spina Bifida , kuchepa kwa miyendo , gastroschisis .
- Loratadine (Claritin)) : Hypospadias .
- Chlorpheniramine (Chlor-Trimeton)) : Zowonongeka kwa diso, kumva zofooka, Spina Bifida, kumveka bwino komanso kumveka bwino.
- Doxylamine (Unisom)) : Cleft lip ndi cleft palate, pyloric stenosis, matenda osokonezeka a mtima, Spina Bifida, ndi neural tube defects.
Chifukwa chakuti pafupifupi 15% mwa amayi apakati akufotokoza kutenga antihistamine m'zaka zitatu zoyambirira, kagulu ka ofufuza a ku Boston, Massachusetts, ndi Singapore anafuna kupeza chitetezo cha antihistamines chomwe chinatengedwa pa 1 trimester yoyamba ya mimba.
Ofufuzawa anafufuza deta yomwe yasonkhanitsidwa zaka 12, kuchokera mu 1998 mpaka 2010, pa ana opitirira 13,000 obadwa ndi zilema zobereka, ndipo amawayerekezera ndi ana pafupifupi 7,000 opanda zilema zobereka. Pafupifupi ana 14 peresenti ya ana onse anali atagonjetsedwa ndi antihistamines osiyanasiyana omwe amayi adatenga pakati pa trimester yoyamba ya mimba.
Ma antihistamines ena, monga Benadryl ndi Claritin, awonjezeka pa nthawi yogwiritsira ntchito mimba, pamene kugwiritsa ntchito ma antihistamines, monga Chlor-Trimeton ndi Unisom achepa.
Kodi Antihistamine Amaonedwa Kuti Ali Otetezeka Pakati pa Mimba?
Deta kuchokera pa phunziroli ikulimbikitsa kwambiri kuti antihistamines nthawi zambiri amawoneka otetezeka pa nthawi ya mimba. Mgwirizanowu wakale pakati pa ntchito ya antihistamine pa zovuta zoyambirira ndi zitatu za kubadwa sizinatsimikizidwe mu phunziro lino. Komabe, pofuna kuyesa chiopsezo chotenga zolakwika zina zobereka, ochita kafukufukuwa anapeza mgwirizano pakati pa kugwiritsa ntchito Chlor-Trimeton ndi kachilombo ka neural kapenanso matenda osiyanasiyana. Panalinso mgwirizano pakati pa kugwiritsidwa ntchito kwa Benadryl ndi mtundu umodzi wa maganizo okhudzidwa mtima ( kusintha kwa mitsempha yayikulu ). Komabe, olembawo amasamala kuti afotokoze kuti izi ndizo zifukwa zokha zomwe zimafuna kuphunzira mopitirira.
Choncho, ngakhale kuti palibe mankhwala otetezeka pa nthawi yomwe ali ndi mimba, mgwirizano wapakati pakati pa antihistamine wogwiritsira ntchito m'zaka zitatu zoyambirira ndi zolephereka kubadwa sizinatsimikizidwe mu phunziro lalikulu laposachedwapa. Ngakhale kuti antihistamines ambiri alipo OTC popanda mankhwala, amayi apakati ayenera kupeza uphungu kwa dokotala musanayambe kumwa mankhwala, makamaka pa 1 trimester yoyamba ya mimba.
Mankhwala aliwonse omwe atengedwa pa nthawi yomwe ali ndi mimba amatengedwera bwino kwa nthawi yayitali kwambiri, ndipo pa mlingo wotsikira kwambiri umene umathandiza kuchiza zizindikiro. Phindu la kumwa mankhwala alionse liyenera kuyeza kuti lisamamwe mankhwala.
> Zotsatira:
> Li Q et al. Kuyezetsa kwa Antihistamine Gwiritsani Ntchito Kumayambiriro kwa Mimba ndi Zofooka za Kubadwa. J Zachilombo Zamtundu wa Immunol. 2013; 1: 666-74.
> Honein MA, ndi al. Chitetezo kapena ngozi ya Antihistamine Kugwiritsa Ntchito Pathupi: Deta Yolimbikitsa Ndi Yothandiza Koma Siyokwanira. J Zachilombo Zamtundu wa Immunol. 2013; 1: 675-6.