Calcitonin Yophatikizidwa ndi Mthenda ya Gene mu Kuteteza kwa Migraine

Zotsatira Zoyamba pa Mankhwala Amene Amayang'ana CGRP ndi Wopereka Wake

Peptide yamtundu wa Calcitonin (CGRP), mapuloteni opangidwa ndi maselo ena a mitsempha m'katikatikati mwa mitsempha ya pakati ndi mitsempha ya mitsempha yaumidzi, amakhulupirira kuti imathandiza kwambiri pamagraines. Mapuloteni ameneŵa amapezeka kuti akukwera pa nthawi ya migraine, koma kuchepetsa kupweteka kwa migraine ndi mankhwala a migraine otchedwa triptan amagwirizana ndi kukhazikika kwa magulu a CGRP m'magazi.

Panthawi ya kugwidwa kwa migraine, n'zotheka kuti maselo ena amachititsa kuti mitsempha ya m'magazi ichepetse, kapena yowonjezera. Mitsempha ya m'magazi yowonongeka imayambitsa katemera wambiri. Akangoyambitsidwa, magulu a mitsempha yotchedwa trigeminal nerve fibers amatumiza kupweteka kwa ubongo - zomwe zimapangitsa kumasulidwa kwa mapuloteni osiyanasiyana, monga CGRP.

CGRP imachititsa kuti mitsempha yambiri yamagazi iwonjezedwe komanso zina zotchedwa "neurogenic kutupa". Pamene migraine ikuukira, ubongo umakhala wolimbikitsidwa. Zimenezi zimapangitsa kuti munthu azivutika kwambiri pamutu komanso kuwonjezeka kwa chilengedwe.

Kodi Maphunziro Otsogolera akuwonetsa chiyani pa CGRP?

Maphunziro a Gawo lachiwiri - maphunziro opangidwa ndi ochepa odwala kuti apeze ubwino ndi zotsatira za zotsatira za mankhwala - mpaka pano akulonjeza kuti ma antibodies onsewa amateteza migraines ndipo amalekerera.

Mu phunziro limodzi, anthu 217 omwe ali ndi zaka 4 mpaka 14 amatha kusinthasintha mwezi umodzi, amangochita mwakachetechete kulandira majekeseni khungu kawiri mlungu uliwonse wa mankhwala omwe amatchedwa LY2951742 kapena malobo - shuga kapena jekeseni la madzi - kwa milungu 12.

(LY2951742 ndi anti antibody ku calcitonin yokhudzana ndi jini (CGRP) - izi zikutanthauza kuti zimamangiriza ku CGRP ndi kuimitsa kapena kuiika).

Zotsatira zimapereka kuti ophunzira omwe alandira LY2951742 amakhala ndi kuchepa kwakukulu mu chiwerengero cha masiku awo a mutu wa migraine poyerekeza ndi placebo. Uthenga wabwino ndi wakuti mankhwalawa amapezeka kuti ali otetezeka komanso ololedwa bwino ndi nkhanizo.

Izi zikunenedwa kuti zotsatira zake zikuphatikizapo:

• jekeseni wa jekeseni
• ululu wamimba
• Matenda opatsirana apamwamba (mwachitsanzo, bronchitis)

Mankhwala ena otchedwa ALD403 - komanso omwe amachititsa kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda, ayesedwe. Gawo limodzi la maphunziro omwe analandira mwakachetechete mamita 1000mg osakanikirana (kudzera mu mitsempha) mlingo wa mankhwala, pamene theka lina analandira placebo. Nkhanizo zinatsatiridwa kwa miyezi 6.

Pa masabata 5 mpaka 8, ophunzira omwe adalandira mankhwalawa adawona kuchepetsa kuchepa kwa 66 peresenti ya masiku omwe anavutika ndi migraine ndi 52 peresenti kwa iwo omwe adalandira placebo.

Komanso, pa masabata 12, odwala 16 peresenti ya omwe adalandira mankhwalawa anali osasunthika mosavuta ndi ena omwe adalandira placebo.

Pomaliza, mankhwala ena, omwe amagwiritsidwa ntchito pansi pa khungu (injection subcutaneous) yotchedwa AMG 334 - anti antibody yomwe imamangiriza ku CGRP receptor (malo otsegula a CGRP) - posachedwapa anapezedwanso pofuna kuteteza migraines. Monga mankhwala ena awiri, AMG 334 anali ololedwa bwino. Zotsatira zovuta kwambiri zinali:

• zizindikiro zozizira
• kutopa
• mutu kapena migraine (kupita chifaniziro - chochepa kwambiri, 3 peresenti poyerekeza ndi 1 peresenti mu gulu la placebo)

• kunyoza
• Matenda opatsirana apamwamba (mwachitsanzo, bronchitis).

Mfundo Yofunika Kwambiri

Izi zimakhala zotsatira zokondweretsa kwambiri kumudzi wa migraine. Ngakhale zili choncho, kuphunzira kwakukulu kachitatu - maphunziro omwe ali akuluakulu ndi kutsimikizira zomwe zimayambitsa maphunziro a Gawo II - ziyenera kuchitika musanayambe kumwa mankhwalawa.

_Zotsatira:

_{Bigal ME, Walter S, Wokhululuka AM. Calcitonin ya majeremusi yonena za peptide (CGRP) ndi kumvetsa kwamtundu wa migraine komanso chikhalidwe cha chitukuko. Mutu . 2013; 53 (8): 1230-44.}

_{Durham PL. Calcitonin Gene-Related Peptide (CGRP) ndi Migraine. Mutu. 2006; 46 (Suppl 1): S3-S8.}

_{Goadsby PJ, & Edvinsson L. Machitidwe a trigeminovascular ndi migraine: kafukufuku omwe amaonetsa kusintha kwa khungu ndi ma neuropeptide zomwe zimawoneka mwa anthu ndi amphaka. Ann Neurol. 1993 Jan; 33 (1): 48-56.}

_{Zotsatira Zoyamba za ALD403, A New Investigational Medicine for Prevention Migraine. (nd). Mu Society of Headache American. Inabweretsanso May 18th, 2014.}

_{Sun H et al. Kutetezeka ndi kuthandizira kwa AMG 334 pofuna kupewa matenda osokoneza bongo. Lancet Neurol. 2016; 15 (4): 382-90.}