Benfotiamine ndi mawonekedwe a anthu a thiamine kapena B1. Thiamine ndi vitamini wosasungunuka ndi madzi ndipo sichigwiritsa ntchito mosavuta thupi. Benfotiamine ndizosakanikirana ndi mafuta ndipo zimapangidwira bwino komanso zimagwiritsidwa ntchito. Pali umboni wina wakuti benfotiamine ingathandize kuthetsa mavuto aakulu a shuga monga retinopathy, nephropathy, ndi neuropathy.
- Kodi matenda obwera chifukwa cha shuga ndi chiyani?
- Kodi matenda a shuga ndi Nephropathy ndi otani?
- Kodi matenda a shuga ndi chiyani?
Benfotiamine kwa Diabetes Neuropathy
Benfotiamine waphunzirapo kangapo zaka zaposachedwapa. Cholinga chachikulu cha maphunzirowa chimaphatikizapo kugwiritsa ntchito benfotiamine monga chithandizo cha matenda a shuga.
Matenda ambiri a shuga amayamba chifukwa cha hyperglycemia yaitali (shuga wambiri wa magazi) chifukwa cha kuchepa kwa magazi m'magazi kapena kupitirira kwa matenda pa nthawi. Kupaka kwa shuga koopsa m'magazi kumaikidwa m'maselo a mitsempha ndi mitsempha yaing'ono yamagazi kumapeto, kuwonongeko m'maderawa omwe amachititsa zizindikiro ndi zovuta.
Njira Zinayi Zowonongeka kwa Ma Cellular
Pali njira zinayi zosiyana zomwe zimachitika m'thupi lomwe lingayambitse kuwonongeka kwa mitsempha ya magazi chifukwa cha hyperglycemia mu shuga.
- Mapulogalamu apamwamba otsekemera m'mimba (ZAKA)
- Protein kinase C (PKC)
- Hexosamine njiraway activation
- Kugwiritsa ntchito njira ya Polyol
Benfotiamine ikuwoneka kuletsa njira zitatu izi mu maphunziro azachipatala. Nkhani ina, yomwe inalembedwa m'nyuzipepala yotchedwa Nature Medicine mu February 2003, yomwe imatchedwa "Benfotiamine Blocks Three Major Way of Hyperglycemic Damage and Prevents Retinopathy", inasonyeza kuti kachilombo ka benfotiamine kanateteza matenda a shuga m'matumba a laboratory.
Zamakono Zopangira Glycation Products
Matenda a hyperglycemia amachititsa kuwonongeka m'mitsempha ya mitsempha ndi mitsempha ya thupi, yomwe imakhala mavuto aakulu a shuga. Kuwonongeka kumachitika pamene kupitirira kwa shuga mu magazi kumathera mu maselo ndipo kumapanga chinthu chodziwika ngati mapulogalamu oyambirira a glycation endproducts (ZAKA) Izi zimagwiritsidwa ntchito pakapita nthawi. ZAKA zambiri zimapezeka m'mitsuko ya maso, impso, ndi mapeto. Amapezekanso m'mitsuko ina yambiri ya mitsempha ndipo amatsogolera ku mapangidwe a ziphuphu ndi matenda a atherosclerosis, zomwe zimawathandiza kudwala matenda a mtima.
Kodi Benfotiamine Ndi Chiyani?
Kafukufuku wasonyeza kuti benfotiamine ikuwoneka kuti imathandiza kuchepetsa mavuto a ubongo, matenda obwera m'mimba, ndi nephropathy mwa kulepheretsa kumanga shuga m'ziwiya. Izi zikutanthauza kuti zochitika za matenda a shuga zikhoza kuchepetsedwa kapena kutetezedwa. Kafukufuku wopita kuchipatala cha ADA wa shuga mu 2003 anasonyeza kuti thiamine yapamwamba komanso benfotiamine zikuwoneka kuti zimateteza microalbuminuria ndi proteinuria (mapuloteni mu mkodzo) m'magulu a shuga. Zofukufuku zomwe zachitika pa anthu zasonyeza kuti benfotiamine ikuwonekeranso kuchepetsa ululu wa ubongo.
Mkhalidwe Watsopano wa Benfotiamine
Benfotiamine akadali mu gawo la kuyesedwa kwachipatala. Maphunzirowa akhala akuchitidwa pa makoswe omwe adayambitsidwa kukhala ndi shuga.
Mayesero owonjezereka amafunika kudziwa ngati benfotiamine imagwira ntchito mofananamo kwa anthu omwe ali ndi shuga. Mankhwala ogwira ntchito sayenera kukhazikitsidwa, ndipo zotsatira za nthawi yaitali sizidziwika.
Ngakhale kuti benfotiamine sichivomerezedwa mwachindunji ndi akatswiri a zachipatala ku America panthawi ino, zikuwoneka ngati zingakhale chithandizo chodalirika cha matenda a shuga pamsewu.
Chivomerezo Chimayembekezeredwabe ndi FDA
Dongosolo la Chakudya ndi Mankhwala (FDA) silinayambe kulandira benfotiamine kuti ligwiritsidwe ntchito pagulu. Pali mikangano yokhudza momwe mankhwalawa ayenera kutchulidwira, kaya monga chakudya chowonjezera kapena vitamini.
Pali nkhawa yokhudzana ndi chitetezo cha nthawi yaitali cha benfotiamine komanso chomwe chimapangitsa kuti mukhale otetezeka. A FDA akufuna umboni wochuluka wakuti benfotiamine imapereka zotsatira zomwe zawonedwa mu mayesero.
Chaka chatha, benfotiamine idaperekedwa kwa FDA ngati chakudya chowonjezera, koma chivomerezo chikuyembekezereka panthawi ino.
- FDA Kalata Yoyankha Kugonjetsedwa kwa Benfotiamine monga Chakudya Chakudya
Zotsatira:
> Sitikupita, E., Lederman H., Kopcke W. "Benfotiamine mu Chithandizo cha Diabetic Polyneuropathy - Phunziro Loyamba Loyendetsedwa Ndilo Sabata Lachitatu." International Journal of Clinical Pharmacology, Therapy ndi Toxicology Jun 2005: 304. PubMed.gov. National Library of Medicine ndi National Institutes of Health. 09 Mar 2007.
> Huebschmann, MD, Amy G., Regensteiner, Ph.D., Judith G., Vlassara, MD, Helen, ndi Reusch, MD, Jane EB "Matenda a shuga ndi Mapulogalamu Opambana a Glycoxidation End-Products." Chisamaliro cha Shuga 2006 1420-1432. 09 Mar 2007.
> Melpomemi >, MD, Peppa, Uribarri, MD, Jaime, ndi Vlassara, MD, Helen. "Kutupa, Zakudya Zamakono Zogwiritsira Ntchito Glycation End, ndi Matenda a Shuga: Chomwe Chiri Chatsopano ndi Chimene Chimachita." Kachilombo ka matenda a shuga 2003 186-187. 09 Mar 2007.
> Kugwedeza, MD, Alin, Negrean, MD, Monica, Stratmann, > PHD >, Bernd, Gawlowski, MS, Thomas, Horstmann, Tina, > Gotting >, > PHD >, Christian, Kleesiek, MD, Knut, Mueller-Roesel , MD, Michaela, Koschinsky, MD, Theodor, Uribarri, MD, Jaime, Vlassara, MD, Helen ndi Tschoepe, MD, Diethelm, "Benfotiamine Amateteza Macro- ndi Microvascular Endothelial Dysfunction ndi Oxidative Stress mwa anthu omwe ali ndi mtundu wachiwiri wa shuga. " Chisamaliro cha shuga 2006 2064-2071. 13 Mar 2007.
> "Mankhwala Osokoneza Bongo." Kuchokera Kafufuzidwe Kunena Zoona. 2005. Juvenile Diabetes Research Foundation International. 18 Mar 2007.
> Hammes, Hans-Peter, Xueliang Du, Diane Edelstein, Tetsuya Taguchi, Takeshi Matsumura, Qida Ju, Jihong Lin, Angelika Bierhaus, Peter Nawroth, Dieter Hannak, Michael Neumaier, Regine Bergfeld, Ida Giardino, Michael Brownlee. "Benfotiamine Blocks Njira Zitatu Zambiri za Kuwonongeka kwa Hyperglycemic ndi Kuletsa Kufufuza Kwambiri kwa Diabetes Retinopathy." Nature Medicine, 18 Feb. 2003, 294-299. 18 Mar 2007.