Kugwiritsira ntchito nthawi yaitali kapena kugwiritsidwa ntchito mopitirira muyeso wokhudzana ndi matenda aakulu
Proton pump inhibitors (PPIs) ndi gulu la mankhwala omwe cholinga chake ndi kuchepetsa mimba ya asidi. Amagwiritsidwa ntchito pochiza matenda ambiri okhudzana ndi asidi kwa zaka zopitirira 20 ndipo amadziwika kuti ali otetezeka komanso ogwira mtima kwambiri kotero kuti athandizidwa kwambiri ndi H2 monga mankhwala osankhidwa.
Izi sizikutanthauza kuti ma PPI alibe zovuta kapena zoperewera.
Ngakhale kuti zotsatira zambiri zimakhala zosavuta komanso zogwiritsidwa ntchito, pali zochitika zambiri zovuta zomwe zingagwiritsidwe ntchito nthawi yaitali kapena kugwiritsira ntchito mopitirira muyeso. Izi zikuphatikizapo mavuto ndi kuyamwa kwa mchere, kusintha kwa mafupa, ndi kuopsa kwa matenda ena osatha.
Momwe Mavitamini a Pulotoni Amagwirira Ntchito
Proton pump inhibitors amagwiritsidwa ntchito pochiza matenda monga reflux gastroesophageal (GERD) , zilonda zam'mimba , ndi zilonda zam'mimba , Madokotala angagwiritse ntchito kugwiritsa ntchito PPI yekha kapena kuphatikizapo antacids. Angagwiritsenso ntchito kuphatikiza ndi mankhwala enaake pamene akuchiza Helicobacter pylori (mabakiteriya omwe amagwirizanitsa ndi zilonda za m'mimba).
Mapulogalamu a PPI amagwiritsa ntchito selo pamtambo wa m'mimba yomwe imatchedwa parietal cell yomwe cholinga chake ndi kupanga hydrochloric acid (HCL). Pochita zimenezi, mimba sichikhoza kutulutsa HCL, kuti zilonda zichiritse komanso zisamayende bwino.
Mapulogalamu a PPI amasiyana ndi a H2 omwe amapanga mapaipi a asidi pamene amadzimadzi a H2 pomwe H2 amatha kuletsa chizindikiro chomwe chimayambitsa kupanga acid. Chifukwa cha izi, PPI imagwira ntchito kwa maola 24 ndikupereka mpumulo kwa maola 72. Olemba H2, mosiyana, amagwira ntchito maola 12.
Mitundu ya Proton Pump Inhibitors
Nthawi zambiri, PPI imasiyana kwambiri ndi ena.
Onse ali ndi njira zofananamo zofanana ndi mitengo yofananamo yogwira ntchito. Ma PPI ovomerezekawa ndi awa:
- Prilosec (omeprazole)
- Prevacid (lansoprazole)
- Protonix (pantoprazole)
- Aciphex (rabeprazole)
- Nexium (esomeprazole)
- Dexilant (dexlansoprazole)
Ngakhale kuti iwo ali ofanana, ma PPI amawoneka othandiza kwambiri pochiza mikhalidwe yeniyeni. Mwachitsanzo, Dexilant ndi Protonix sizimagwiritsidwa ntchito pochiza matenda a H. pylori ; enawo ali. Chifukwa chothandizira kupweteka kwa mtima, Prilosec ndi Prevacid akulimbikitsidwa pamene ena sali. Choncho, ndikofunikira kulankhula ndi dokotala kuti muonetsetse kuti kugwiritsa ntchito PPI n'koyenera.
Zotsatira Zotsatira ndi Kuyanjana
Mukatenga nthawi yochepa, zotsatira zambiri zokhudzana ndi PP! ntchito ndi yofatsa komanso yachangu. Zowonjezereka zimaphatikizapo kudzimbidwa, kutsegula m'mimba, kupweteka kwa mutu, kupweteka mutu, kupwetekedwa m'mimba, kunyoza, ndi kusanza.
umboni wochuluka umasonyeza kuti kugwiritsa ntchito nthawi yaitali kungabweretse mavuto aakulu. Mwa iwo:
- Anthu ena amanena kuti kugwiritsa ntchito PPI kungalepheretse kutsegula kwa calcium, zomwe zimapangitsa kuti mafupa a mafupa ena asokonezeke. Poyankha, bungwe la US Food and Drug Administration linachenjeza mu 2011 kuti alangizi a PPI apitirize kugwiritsidwa ntchito kwa masiku osachepera awiri pa nthawi ya mankhwala atatu kufikira chaka.
- Kugwiritsa ntchito PPI kwa nthawi yayitali kunayanjananso ndi kuwonjezeka kochepa pa chiopsezo cha chibayo chopezeka m'midzi ndi matenda a Clostridium difficile .
- Kafukufuku wasonyeza kuti kugwiritsa ntchito ma PPI kwa zaka khumi ndi khumi ndi khumi ndi ziwiri (12.5%) ya chiwopsezo cha matenda a impso, omwe ndi oposa 8.5 peresenti.
- Kafukufuku wofanana uja akuti anthu omwe anatenga PPIs zaka zisanu ndi ziwiri anali ndi mwayi wokwana 13 peresenti ya kutenga dementia poyerekeza ndi omwe sanatero.
Zambiri mwa zotsatirazi zikuwoneka kuti zogwirizana ndi mfundo yakuti PPI sikuti imachotsa mapampu a asidi m'mimba koma thupi lonse.
Izi zikuphatikizapo gawo la selo lotchedwa lysosome yomwe imagwiritsa ntchito asidi kuchotsa zinyalala. Popanda njira yotere, zowonongeka zingathe kuwonjezereka ndikupangitsa selo kuti iwonongeke komanso kuti ifike zaka zambiri. Chodabwitsa ichi chikhoza kuwerengera kuwonjezeka komwe kumawoneka mu maphunziro.
Zomwe anapezazi zikutsindika mfundo yakuti ma PPI ayenera kugwiritsidwa ntchito panthawi yothandizira kapena chithandizo cham'tsogolo m'malo mwa njira yothetsera matenda opatsirana pogwiritsa ntchito nthawi yayitali.
> Chitsime
- > Jacob Schoenfeld, J. ndi Grady, D. "Zotsatira Zoipa Zogwirizana ndi Proton Pump Inhibitors." Journal ya American Medical Association. 2016: 176 (2): 172-174.