Matenda a shuga ndi Dementia
Kugwirizana kumveka bwino; anthu omwe ali ndi matenda a shuga a mtundu wa 2 ali ndi chiopsezo chachikulu kwambiri chokhala ndi matenda a Alzheimer ndi mitundu ina ya matenda a maganizo. Ndipotu, pali chigwirizano pakati pa matenda awiri omwe Alzheimer amachitcha kuti "Mtundu wa shuga " ndi ena.
Komabe, kafukufuku waposachedwapa akusonyeza kuti pangakhale chinachake chimene tingachite pazoopsazi.
Kwa zaka zingapo, ofufuza akhala akuyesa kuti mwina mankhwala a insulin angathandize pochiza matenda a Alzheimer's . Mwachitsanzo, kafukufuku wina anapeza mgwirizano pakati pa mankhwala ndi mankhwala ochepetsa matenda a insulini komanso kuchepa kwa chiwindi cha matenda a shuga kwa anthu omwe ali ndi shuga.
Kafukufuku
Chimodzi mwa maphunziro atsopano pa matenda a shuga ndi chifuwa chachikulu cha mthupi chimakhudza zomwe zingathandize kuchepetsa chiwopsezo cha matenda a dementia, mosiyana ndi chithandizo cha matendawa pambuyo poti ayambe.
Ochita kafukufuku ku Germany anafotokoza za inshuwalansi za umoyo pa odwala 145,928 omwe ali ndi zaka zoposa 60 pazaka za 2004 mpaka 2010. Amagawira anthu m'magulu osiyanasiyana:
- Alibe matenda a shuga
- Matenda a shuga popanda mankhwala ndi pioglitazone ya mankhwala
- Kuzindikira matenda a shuga omwe amachitidwa ndi pioglitazone ya mankhwala osachepera 8 pa kalendala
- Kuzindikira matenda a shuga omwe amachitidwa ndi pioglitazone ya mankhwala pa malo oposa asanu ndi atatu a kalendala
Kenako anayerekezera kukula kwa chifuwa cha m'magulu mwa magulu onsewa.
Zotsatira
Ndondomekoyi itatha, zotsatira zotsatirazi zapezeka:
1) Monga momwe zinkayembekezeredwa pogwiritsa ntchito kafukufuku wammbuyo, chiwopsezo chachikulu cha matenda a shuga kwa anthu omwe ali ndi shuga chinatsimikiziridwa, ndipo 23% yawonjezeka ngozi poyerekeza ndi omwe alibe shuga.
2) Anthu omwe ali ndi matenda a shuga omwe anachiritsidwa ndi pioglitazone m'malo oposa asanu ndi atatu a kalendala anali ndi chiopsezo chochepa chokhalira ndi matenda a 'dementia'.
3) Ndipotu, chiopsezo chawo cha kuchepa kwa 'dementia' chinali osachepera omwe alibe shuga - ndi 47%. Mwa kuyankhula kwina, anthu omwe akhala ndi chithandizo cha nthawi yaitali cha pioglitazone anali ndi theka la chiopsezo cha dementia poyerekezera ndi anthu omwe alibe matenda a shuga.
4) Amene ali ndifupikitsa nthawi ya pioglitazone (osachepera 8 pa kalendala) anawonetsa chiwopsezo chofanana cha matenda a maganizo poyerekeza ndi anthu omwe alibe shuga.
5) Metformin, mankhwala ena operekedwa kuti athe kuchiza matenda a shuga, amapezedwanso kuti achepetse chiwopsezo cha dementia, koma mpaka pang'onopang'ono.
Zotsatira zochititsa chidwi izi zikusonyeza kuti kugwiritsira ntchito pioglitazone kungachepetse chiopsezo cha anthu omwe ali ndi shuga. Kafukufuku wapangidwa kuti atsimikizire kuti mankhwalawa amapereka phindu limeneli tsopano. Mwamwayi, maphunziro ngati awa akulimbikitsa kwambiri kufufuza pa ubale pakati pa shuga ndi matenda a maganizo.
Zambiri za Pioglitazone
Pioglitazone (dzina lakuti Actos) ndi mankhwala m'kalasi la thiazolidinediones . Amauzidwa kuti azichiza matenda a shuga mwa kuchepetsa kuchepa kwa insulini.
Ngakhale zotsatira za phunziroli zikulimbikitsana kwambiri, pakhala pali mavuto omwe amadziwika ndi kugwiritsa ntchito mankhwalawa kuphatikizapo kupwetekedwa mtima kwa mtima , matenda a chiwindi, khansara ya chikhodzodzo komanso kuopsa kwa mafupa osweka.
Kafukufuku Wopitirira
Kafukufuku wambiri akuchitidwa pogwiritsa ntchito mankhwalawa pochiza komanso kupewa matenda a maganizo. Pitani ku US Clinical Trials kuti muwone zoyesayesa zachipatala zomwe zikuchitika motsatira pioglitazone.
Zotsatira:
Annals of Neurology. 2015 May 14. Zotsatira za mankhwala a pioglitazone pa chiwindi cha matenda a maganizo. http://www.ncbi.nlm.nih.gov/pubmed/25974006
Deutsches Zentrum for Neurodegenerative Erkrankungen eV German Center for Neurodegenerative Matenda mkati mwa Association Helmholtz. Mankhwala a shuga amachepetsa chiwopsezo cha m'maganizo. Idapezeka pa June 25, 2015.https: //www.dzne.de/en/about-us/public-relations/meldungen/2015/press-release-no-8.html
National Institutes of Health. Laibulale ya National National Medicine. Medline Plus. Pioglitazone. February 15, 2014. http://www.nlm.nih.gov/medlineplus/druginfo/meds/a699016.html