Thiazolidinediones ndi mankhwala omwe amathandiza kuchepetsa shuga m'magazi a mtundu wa 2 shuga . Kuwonjezera pa zakudya zabwino ndi zolimbitsa thupi, ndi njira ina yothetsera shuga wa magazi. Amadziwikanso kuti glitazones.
Ku US, thiazolidinediones panopa muli Actos (pioglitazone), Avandia (rosiglitazone), komanso Avandamet (rosiglitazone ndi metformin).
A FDA adaletsa kulembedwa kwa mankhwala a rosiglitizone m'chaka cha 2013 atatha kufalitsa umboni watsopano sanasonyeze kuti chiwopsezo cha mtima chikuwonjezeka, koma ku Ulaya kulibe chiletso.
Dos ndi Dont
Thiazolidinediones amathandiza kuchepetsa kuthamanga kwa insulini m'maselo, kusintha njira yomwe thupi limayankhira ndi insulini. Iwo amatha kutengedwa kamodzi kapena kawiri tsiku ndi tsiku. Kuonjezerapo, iwo angagwiritsidwe ntchito okha, ndi mapiritsi ena, kapena ndi insulini. Thiazolidinediones siimalowa m'malo mwa insulini m'thupi kapena imachititsa thupi kupanga insulini yowonjezera. Iwo sali otsimikiza kuti asinthe chakudya chopatsa thanzi adokotala amalangiza mwina.
Mbiri Yogwiritsira Ntchito
Kuyambira kumapeto kwa zaka za m'ma 1990, thiazolidinediones agwiritsidwa ntchito pochiza mtundu wa shuga wa mtundu wa 2. Mankhwala oyamba m'kalasi iyi, Rezulin, anachotsedwa ku msika wa US chifukwa cha mavuto osawoneka koma oopsa a chiwindi. Nkhani zina zakhala zikudetsa nkhaŵa za kuwonjezeka kwa chiopsezo cha mtima kwa odwala omwe amatenga Avandia.
Malipoti ena adanena kuti chiopsezo cha mtima wa thiazolidinediones chikhoza kuwonjezeka, ngakhale kuti chiyanjano ichi sichitha.
A FDA adalamula, mu 2006, kuti mankhwala a mankhwalawa a Avandia akuchenjeza za kuopsa kwa matenda a mtima komanso kumva kupweteka kwa odwala. Kugwiritsidwa ntchito kwa Avandia kunatsika kwambiri pambuyo poti machenjezo oyambirira adatulutsidwa.
Mu 2010 a FDA analetsa malamulo atsopano a Avandia kwa anthu okha omwe sanathe kulamulira shuga ndi magazi ena a shuga kapena omwe sanathe kutenga Actos.
Mu 2013, zotsatira za mayeso a zachipatala za RECORD sizinapezeko vuto lalikulu la matenda a mtima ndi Avandia (rosiglitazone). Chotsatira chake, mu 2013 a FDA adakweza malamulo omwe adawaika pa Avandia. Pa December 16, 2015, a FDA anachotsa Mchitidwe Wowunika ndi Kukhazikitsa Mphamvu kwa mankhwala a rosiglitazone, poganiza kuti phindu liposa mowopsa.
Komabe, European Medicines Agency inayimitsa malonda a rosiglitazone mu 2010 ndipo Agence za ku France ndi Germany za Ma ARV zimayimitsa ntchito ya pioglitazone (Actos) mu 2011.
Zotsatira Zotsatira ndi Ngozi
Zotsatira zoyipa zimaphatikizapo kupindula, kutentha kwakukulu, matenda a sinus , mutu, ndi kuchepa kwa magazi. Zotsatira zoyipa zimaphatikizapo kusungunuka kwa madzi, mtima wosagawanika, kupweteka kwa thupi, ndi kupweteka kwa minofu. Zotsatira zina zingaphatikizepo kupweteka mutu, cholesterol, kufooketsa mafupa, mavuto a maso ndi ming'oma.
Ngakhale kulibe umboni womwe ukusonyeza kuti Actos kapena Avandia amachititsa mavuto a chiwindi, ndibwino kusamala ndi zizindikiro monga kunyoza, kusanza, kupweteka m'mimba, kutopa, kusowa chakudya, jaundice (khungu la khungu ndi maso), ndi mitsempha yamdima.
Amene Sagwiritse Ntchito Thiazolidinediones
Anthu omwe ali ndi matenda a shuga a mtundu wa 1 (omwe amafunikira insensiti yowonjezera), mtima wolephera, kapena matenda a chiwindi sayenera kugwiritsa ntchito thiazolidinediones. Ana ndi amayi omwe ali ndi pakati kapena akuyamwitsa ayenera kupeŵa kugwiritsa ntchito mankhwalawa. Anthu omwe ali ndi vuto la maso kapena phungu ayenera kukambirana ndi athandizi awo asanatenge thiazolidinediones.
Zina Zogwiritsira Ntchito Zopuma
Actos angathandize kuthana ndi cholesterol. Thiazolidinediones angathandizenso kuwonjezera ovulation ndi kubala mu polycystic ovary syndrome.
Zomwe Mungadziwe Zokhudza Thiazolidinediones
Thiazolidinediones ayenera kutengedwa tsiku lililonse.
Zitha kutenga miyezi itatu kuti zitheke. Ngati wina ali ndi zotsatirapo zina, makamaka kutupa, kupweteka mwadzidzidzi, kupuma kovuta, kuthamangira mtima, kusintha kwa msambo, kapena mafupa osweka, dziwitsani wothandizira odwala nthawi yomweyo.
Anthu omwe ali ndi shuga, sayenera kumwa kumwa mankhwala pokhapokha atapatsidwa malangizo. Ndikofunika kuonana ndi dokotala kuti azisamalidwa mwachidwi pamene akutenga thiazolidinediones. Izi zikuphatikizapo kuyezetsa shuga, kuyesa ntchito, ndi kuyesa kwa diso.
Zotsatira:
Mahaffey, Kenneth W .; Hafley, Gail; Dickerson, Sheila; Burns, Shana; Tourt-Uhlig, Sandra; White, Jennifer; Newby, L. Kristin; Komajda, Michel; McMurray, John; Bigelow, Robert; Kunyumba, Philip D.; Lopes, Renato D. (2013). "Zotsatira za kuyambiranso kwa zotsatira za mtima m'mutu wa RECORD". American Heart Journal 166 (2): 240-249.e1.
Drazen, MD, Jeffrey M., Stephen Morrissey, Ph.D., ndi Gregory D. Curfman, MD "Rosiglitazone-Anapitirizabe Kukayikira za Chitetezo." The New England Journal of Medicine. 357 (2007): 63-64.
Kulankhulana kwa Drug Safety Drug: FDA imafuna kuchotseratu malamulo ena oletsa matenda a shuga a rosiglitazone. Chipinda cha FDA. 11/25/2013. US Food and Drug Administration.
David K. McCulloch, MD. "Thiazolidinediones pochiza matenda a shuga," Dec. 17, 2015. UpToDate.