Pali vuto lina lomwe lingakhalepo pakati pa mankhwala a Xolair (omalizumab) ndi khansa. Pambuyo pa Xolair ikuvomerezedwa kuti igwiritsidwe ntchito ku United States, lipoti loyambirira la mtsogoleri wa chitetezo cha FDA linali ndi ndime zotsatirazi:
"Kuyerekezera za malignancy rates (koma osakhazikitsa) chiwerengero chowonjezeka cha nkhani za Omalizumab ... Kufanizitsa kwa deta yophunzirira zachipatala ku chidziwitso chachikulu cha epidemiological kunanena kuti nkhani za Omalizumab zowonongeka zowonongeka kuposa momwe zinkayembekezeredwa pamene gulu lolamulira linayamba kuchepa malignancies. "
M'mayesero a kachipatala, khansa inkawonedwa mwa mmodzi mwa anthu odzipereka omwe anachitidwa ndi Xolair (odwala 20 pa 4127) poyerekeza ndi mmodzi mwa anthu odzipereka asanu omwe sanatengere Xolair (odwala 5 pa 2236). Khansa inali ya mitundu yosiyanasiyana. Khansa yomwe inachitikira kangapo mu gulu ili:
- Khansara ya m'mimba
- Khansara ya khungu (khansa ya khansa komanso malalanoma)
- Khansa ya prostate
Panali ma khansa ena asanu omwe anachitika nthawi imodzi.
Ndikofunika kuzindikira kuti ngati wina ali ndi khansa asanayambe maphunziro a Xolair, iwo sanatuluke pamaphunziro - inde, akuganiza kuti odwala asanu aliwonse ali ndi zizindikiro za khansa asanalowe muyeso ya kuchipatala. Zotsatira zake, sizikanakhala zovuta kuti Xolair iwononge khansa mwa odwala awa.
Odwala amakhalanso ndi khansa m'kanthawi kochepa atayamba mankhwala ndi Xolair. N'zosatheka kuti khansa ikhale ikukula mu nthawi yochepa - kutanthauza, iwo akhoza kale kukhala ndi khansa musanayambe Xolair.
Pambuyo pake, gulu la oncologists lanena kuti silikuganiza kuti mankhwala a Xolair amachititsa khansa yochokera pa deta yomwe ilipo.
Zomwe zimakhudza kwambiri Xolair kapena kugwiritsa ntchito kwa anthu omwe ali pachiopsezo cha khansa (monga osuta fodya kapena omwe ali ndi mbiri ya banja la khansa) sadziwika koma akupitiriza kuphunzira.
Epidemiologic Study of Xolair (omalizumab): Kuwona Kuchita Kachilombo ndi Kupewa Kwanthaŵi Yaitali kwa Odwala ndi Chisokonezo Chosavuta Kumvetsa kudzawona zotsatira za nthawi yaitali za Xolair zokhudzana ndi mitundu yosiyanasiyana ya khansa.
Kupenda kwa 2014 kwa zaka zisanu zoteteza chitetezo cha Xolair sichidawone kusiyana kwa khansa pakati pa odwala Xolair ndi omwe sankachiritsidwa ndi Xolair. Mankhwalawa agwiritsidwanso ntchito ndi zikwapulo zazing'ono zomwe zimadziwika ngati kuukira kwa ischemic kosakhalitsa . Kusokonezeka kwa mtima; zowawa mwadzidzidzi; kuthamanga kwa magazi m'mitsempha yamapapu yotchedwa pulmonary hypertension; ndi magazi mu mapapo ndi mitsempha. Komabe, a FDA sangathe kunena ngati Xolair kapena ayi ikuthandizira kuthetsa mavutowa kapena ayi chifukwa cha kuunika kwa umboni umene ukupezekapo. Chifukwa chakuti FDA silingathe kunena momveka bwino kuti pali mavuto omwe amabwera chifukwa cha mavuto a mtima ndi ubongo, a FDA adawawonjezera ku gawo la zovuta zomwe zimachitika pa tsamba la mankhwala. Mofananamo, a FDA sangathe kunena mwatsatanetsatane kuti palibe chiopsezo cha khansa ndi Xolair, kotero kuti chidziwitso chokambirana pa mutuwu chinawonjezeredwa ku gawo la machenjezo ndi ndondomeko ya mankhwala a mankhwala.
Ngati mungaganizire Xolair ngati chithandizo cha mphumu ya mwana wanu kapena ya mwana wanu muyenera kukambirana nkhaniyi ndi dokotala wanu.
A FDA akusonyeza kuti madokotala nthawi zonse amawonekeranso kufunikira kwa mankhwala opitirira Xolair odwala matenda odwala matenda a mphumu.
> Zotsatira:
> Lanier B. Osayankhidwa mafunso okhudzana ndi matenda okhudzana ndi ntchito ya > anti-immunoglobulin > E m'matope komanso osatopic matenda. Kupuma kwa mphumu Proc. Proc 27 >: S37 > -S42, 2006)
> Zovomerezeka Mbiri, Letters, Reviews, ndi Related Documents. Zolembedwa Zopangira XOLAIR (OMALIZUMAB)
Katie Eder. Pharmacy TimesFDA Imaphatikiza Mavuto a Mtima ndi Ubongo Mavuto, Khansa ku Xolair Label.
> F SA.gov FDA Drug Safety Communication: FDA imavomereza kusintha kwa chizindikiro cha mankhwala a asthma Xolair (omalizumab), kuphatikizapo kufotokoza> pang'ono > kuopsa kwa mtima ndi ubongo zochitika.