Matenda a Parkinson amakhudza ubongo ndi maselo a mitsempha ndipo zimayambitsa mavuto ndi kusuntha kwa minofu; Khansa ya m'magazi ndi mtundu wa khansa yomwe imakhudza mafupa ndi magazi. Matenda a Parkinson ndi osowa kwambiri kwa ana; pamene khansa ya m'magazi ndi khansa yambiri ya ubwana. Kodi matendawa angakhale osiyana bwanji?
Chabwino, anthu omwe ali ndi Parkinson ndi anthu omwe ali ndi khansa ya m'magazi amakhala ndi zofanana kwambiri-zolemetsa zokhudzana ndi matenda awo. Komabe, m'mabuku a sayansi amaperekanso ochepa omwe angakhale okhudzidwa ndi iwo omwe akufuna kugwirizana pakati pa matenda awiriwa.
Mankhwala Ochepetsa Matenda a Mthupi Amaonekera Pochepetsa Zizindikiro za Parkinson
Tasigna (nilotinib) ndi mankhwala ovomerezeka kuti athetse mitundu yambiri ya khansa ya m'magazi. Pogwiritsa ntchito gulu laling'ono la ophunzira, nilotinib ikuwoneka kuchepetsa zizindikiro kwa anthu omwe ali ndi matenda a Parkinson omwe ali ndi chifuwa chachikulu cha matenda a maganizo kapena Lewy thupi la maganizo.
Malinga ndi lipoti la NPR, mayesero a odwala 12 omwe anapatsidwa mayeso aang'ono a nilotinib adapeza kuti kayendetsedwe kake ndi kaganizidwe kake kamasintha mwa anthu 11 omwe anamaliza mayeso a miyezi isanu ndi umodzi. Akatswiri ofufuza anafotokoza zotsatirazi pa msonkhano wa Society for Neuroscience ku Chicago. Phunziro lapang'ono kwambiri, silinalinganizidwe kuti liziyenda bwino ndipo panalibenso kuyankha kwa zotsatira za placebo.
Komabe, zotsatirazi zinali zosangalatsa kwambiri ndipo zidzalimbikitsa kufufuza kwamphamvu.
Nilotinib ali m'gulu la mankhwala otchedwa kinase inhibitors. Zowonjezera, nilotinib ndilowetsa tizilombo ta BCR-ABL. Kinases ndi gulu lina la ma enzyme, GTPases, sikuti limangokhala ndi matenda a m'maganizo, koma amathandizidwa ndi matenda ena osiyanasiyana omwe amaphatikizapo khansara ndi zotupa.
Ngakhale kuti mankhwalawa sanapangidwe ndi matenda a Parkinson, sizosatheka kuti sayansi ikhale yopindulitsa kwa matendawa.
Madzi Omwa Omwe Amakhudzidwa Kwa Onse
Kafukufuku wofalitsidwa mu gazeti la "Environmental Health" la August 2014, adagwiritsa ntchito kuti madzi ena akumwa ku US Marine Corps Base Camp Lejeune, North Carolina, anali atayipitsidwa ndi kusungunula m'zaka za 1950 mpaka 1985. A gulu la ofufuza anafufuza zotsatira za ngoziyi poyerekezera zifukwa za imfa pakati pa antchito a Camp Lejeune ndi Camp Pendleton, kumene madzi anali oyera.
Zimakhala zovuta kuthetsa vuto ndi zotsatira pamene mukuyang'ana kumbuyo, ndipo zotsatira za phunziro ili zimasuliridwa mosamala. Komabe, mu phunziro ili, kunawoneka kuti pali ngozi yaikulu ya imfa yomwe imakhudzana ndi matenda osiyanasiyana, kuphatikizapo khansa ya impso, khansa ya m'magazi, myeloma, ndi matenda a Parkinson pakati pa ogwira ntchito omwe adawonekera ku Camp Lejeune.
Kuwonetsera kwa Mankhwala Ogwiritsidwa Ntchito Pamodzi
Matenda ambiri a matenda a Parkinson ndi khansa ya m'magazi amakhulupirira kuti amakhala ndi njira zambiri zowonjezera, zomwe zingakhale ndi mitundu yosiyana siyana ya zachilengedwe komanso majini ambiri okhudzana ndi chilengedwe.
Kuphunzira chitukuko cha matenda oterewa chifukwa cha chinthu chimodzi, ndipo kutero kumayang'ana kumbuyo nthawi ndizovuta kwambiri. Komabe, pali chithandizo chogwirizana pakati pa mankhwala ophera tizilombo, herbicides ndi poizoni ndi khansa ya m'magazi komanso matenda a Parkinson. Malinga ndi kafukufuku mu magazini ya May 2013 ya magazini yotchedwa Neurology , mabuku a sayansi amachirikiza lingaliro lakuti kuyang'ana mankhwala ophera tizilombo kapena solvents ndi chinthu chowopsa kwa Parkinson, koma kufufuza kwina kuli kofunikira kutsimikizira mgwirizano ndi zotsatira. Paraquat (paraquat dichloride, kapena methyl viologen), mwachitsanzo, ndi mankhwala a herbicide omwe amawoneka ngati chiopsezo cha matenda a Parkinson.
Mofananamo, gulu la ofufuza ku Costa Rica linayesa kuphunzira mgwirizano pakati pa makolo omwe adapezeka ndi mankhwala ophera tizilombo komanso omwe ali ndi chiopsezo cha khansa ya m'mimba mwa ana awo. Ngakhale kuti sakanatha kuwonetsa kuti zingakhale zosavuta kuchita pazinthu zambiri zomwe adazifufuza, adawona chizoloŵezi choonjezera chiwopsezo cha khansa ya m'magazi ndi mankhwala ophera tizilombo-makamaka amayi omwe akuwoneka ndi mankhwala ophera tizilombo pa nthawi yoyamba ndi yachiwiri ya mimba.
Zotsatira:
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NPR. Kodi Matenda a Kansa Angatsitsirenso Matenda a Parkinson ndi Dementia?
Hong L, Sklar LA. Kufufuza GTPases ku Parkinson's disease: kuyerekeza ndi mbiri yakale ya mankhwala a kinase opezeka ndi mankhwala. Malire mu Molecular Neuroscience . 2014; 7: 52.