Chithandizo Chosungunuka Chabwino Chothandizira Migraine Yosatha
Chithandizo cha migraine chosatha chimaphatikizapo njira zowonongeka, monga kupepesa, ndi mankhwala osokoneza bongo. Ngakhale kuti izi zimagwira ntchito kwa anthu ena, zina zimatsutsa kapena zosagwirizana ndi njira zowonongekazi. Muzochitika izi, wina angaganizire zamankhwala ena omwe si achikhalidwe, monga Botox .
Kodi Botox N'chiyani?
OnabotulinumtoxinA, yomwe imadziwika ndi dzina la malonda a Botox, ndi poizoni wopangidwa ndi bakiteriya Clostridium botulinum ndipo amagwira ntchito poletsa kugwirizanitsa mitsempha, yomwe imachepetsa minofu. Botox inavomerezedwa ndi FDA mu 2010 kuti athe kupewa matenda a migraine osatha.
Jekeseni wa Botox chifukwa cha matenda osaphatikizapo a migraine ndi njira yofulumira, yomwe imakhala nthawi yayitali kwa mphindi 10 mpaka 15, ndi malo ambiri ozungulira mutu ndi khosi akujambulidwa. Ngakhale pangakhale kutengeka kochepa komwe kumagwirizanitsidwa ndi jekeseni iliyonse, vuto limakhala lachidule, ndipo anthu ambiri amalekerera bwino.
Kodi Botox Igwira Ntchito?
Sayansi yotsatira Botox imalonjeza, ngakhale kuti maphunziro osokoneza dziko lapansi amasonyeza kuti pang'ono ndi zotsatira zimakhala zabwino.
Kafukufuku wina wa mutu wa mutu unafotokoza odwala pafupifupi 1300 omwe ali ndi matenda osagwira mtima ochokera ku PREMPT. Pulogalamu ya PREEMPT ndi mayesero a masabata asanu ndi awiri (56) omwe akuyesa kugwiritsa ntchito Onabotulinumtoxin A ngati njira yothandizira kuti munthu asatenge chithandizo cha migraine.
Mu phunziro la PREEMPT, ophunzira adangokhalira kulandira majekeseni pamutu ndi m'khosi za Onabotulinumtoxin A kutsogolo kwa jekeseni wa placebo masabata khumi ndi awiri (5 injections). Mwa omverawo, 35 peresenti adalephera katatu mankhwala ochepetsera mankhwala, koma 65 peresenti adalephera chimodzi.
Onsewa anadziŵa kuti ali ndi matenda a migraine osatha. Ophunzira ndi Botox injection sankadziwa chithandizochi, kutanthauza kuti sakudziwa kuti ali ndi jekeseni (Botox ndi Placebo).
Zotsatira zinasonyeza kuti omwe adalandira majekeseni a Onabotulinumtoxin A akhoza kuchepetsa chiwerengero cha mitu yawo pamapeto pa phunziro (masabata 56). Iwo amakhalanso ochepa kuti adzichepetse "kuchepa kwa mutu" pang'ono pa masiku omwe anali ndi mutu.
Phunziro lapadera mu Journal of Headache and Pain , odwala 254 omwe ali ndi matenda a migraine osachiritsika anajambulidwa ndi Onabotulinumtoxin A ku Clinic Hill Migraine ku England. Oposa 90 peresenti ya ophunzirawa adayesa njira zitatu zothandizira kuti asatengeke m'mbuyo ndipo sanayankhe. Iwo anapanga jekeseni wa Botox mu njira yofananamo, monga izo zinachitikira mu PREEMPT phunziro. Ophunzirawo adasunga zolemba masiku osachepera makumi atatu ndi atatu asanalandire jekeseni.
Zotsatira zinawulula kuti OnabotulinumtoxinAcheperachepera masiku ammutu ndi masiku a migraine ndi osachepera 50 peresenti, ndipo masiku ochulukirapo amayamba kupuma kuchokera pazotsatira. Chiŵerengero cha odwala omwe anapeza kuchepa kwa 75 peresenti ya masiku opweteka ndi masiku a migraine anali 14 peresenti ndipo 24 peresenti, motero.
Ntchito ya OnabotulinumtoxinUkugwiritsiranso ntchito kunabweretsa kuwonjezeka kwa ntchito.
Pomalizira, kuphunzira ku JAMA , komwe kunayesedwa kwakukulu pa mayesero angapo olamuliridwa ndi randomzedwe omwe amafanizira botulinamu poizoni A ndi placebo, naperekanso chithandizo chaching'ono cha migraine-Botox. Mwachidule, ophunzirawa anaphatikizapo mitundu yosiyanasiyana ya mutu monga: episodic migraine, kupweteka kwa mutu, komanso mutu wa mutu wa migraine.
Zotsatira zimasonyeza kuti Botox ndi yopindulitsa popewera matenda a migraine, koma osati mu episodic migraine kapena mutu wopweteka mutu. Ndikofunika kudziwa kuti kuchepetsa kwenikweni kwa nthenda ya mutu pamwezi mu phunziroli kunapezeka kuti ndi masiku awiri kapena atatu - ochepa, koma ofunika kwa ambiri.
Zili ngati kukhala ndi mlungu umodzi pamwezi wopanda mutu.
Kodi Downsides ya Botox ndi chiyani ?:
Chifukwa chimodzi, monga mankhwala alionse, pali zotheka zowononga. Phunziro la JAMA , zotsatirapo izi zinawonetsedwa mwa anthu ambiri omwe akugwira nawo jekeseni wa Botox kusiyana ndi gulu la placebo-zomwe zikunenedwa, iwo akadali ochepa, koma akuyenera kutchula.
- Kufooka kwa minofu
- Blepharoptosis
- Khungu lolimba
- Paresthesia
- Kuuma kwa misasa
- Kupweteka kwa misempha
Mutu umatha chifukwa cha jekeseni wa Botox-zovuta kwambiri-koma osadandaula, izi nthawi zambiri zimakhalitsa.
Cholakwika china ndi chakuti Botox ikhoza kukhala yotsika mtengo kwambiri. Makampani ambiri a inshuwalansi amafuna zolemba zambiri kuti mwalephera njira zina zothandizira kuti musamapange mankhwala a Botox, ndipo nthawi zina, ngakhale izi sizikugwira ntchito.
Mfundo Yofunika Kwambiri
Kafukufuku wambiri wa sayansi ku Botox angakhale othandiza. Izi zanenedwa, Botox ikuwoneka kuti ikupindulitsa popewera migraines osatha. Ndibwino kuti muzindikire kuti mungagwiritse ntchito Botox pamodzi ndi mankhwala ena a migraine-kotero zimakupatsani mpumulo wambiri womwe simunalandira ndi mankhwala anu okha.
Zotsatira:
Aurora SK, Wopambana P, Freeman MC, Spierings EL, OGU, DeGryse RE et al. OnabotulinumtoxinA M Bokosi la Zopweteka Kumutu: Botox-A ya Kuchepetsa Kugonjetsa kwa Migraine : Mafunso Ofunsidwa Kawirikawiri kapena Chithandizo cha Mthenda ya Migraine: Kusanthula Kwadongosolo kwa masabata 56 PREEMPT Clinical Program. Mutu. 2011 Oct; 51 (9): 1358-73.
Jackson JL, Kuriyama A, Hayashino Y. Botulinum Toxin A ya Prophylactic Treatment of Migraine ndi Kutsutsana Mutu mwa Akuluakulu Meta-analysis. JAMA. 2012; 307 (16): 1736-1745.
Khalil M, Zafar HW, Quarshie V, Ahmed F. Cholinga Choyesa Kugwiritsa Ntchito OnabotulinumtoxinA (BOTOX) mu Treatment of Chronic Migraine; Dongosolo la Moyo Wathu mu 254 Odwala Ochokera ku Hull, UK. J Mutu wa Mutu. 2014 Sep 1; 15: 54.
Rothrock, JS (2012). American Headache Society. Bokosi la Zopangira Mutu .