Ranexa (ranolazine) ndi mankhwala atsopano, omwe ali ndi njira yapadera yogwiritsira ntchito angina . Ranexa wakhala akuwonetseredwa kuti akuwone bwino kwambiri nthawi ya odwala omwe ali ozikika angina omwe amatha kuchita masewera olimbitsa thupi asanakhale ndi zizindikiro ndipo adavomerezedwa ndi FDA mu 2008 ngati mtsogoleri woyamba wa angina.
Poyamba ankakhulupirira kuti Ranexa amachititsa mtima wa mitsempha kuchoka pogwiritsa ntchito mafuta acidi kuti shuga ipange mphamvu, zomwe zimachepetsa mpweya wa mitsempha ya mtima yomwe ikufunika kugwira ntchito.
Posachedwapa, pali umboni wina womwe unasonyeza kuti zotsatira za Ranexa ndizoletsera zomwe zimatchedwa "sodium channel" m'maselo a mtima, omwe akuvutika ndi ischemia , kapena kusowa kwa oxygen yokhudzana ndi matenda a atherosclerosis , mu mitsempha yamakono . Kuletsa njira iyi ya sodium kumalimbitsa maselo a mtima wa ischemic, kuchepetsa kuwonongeka kwa minofu ya mtima, komanso kuchepetsa zizindikiro za angina.
Angina N'chiyani?
Angina amamva kupweteka kapena kupweteka mu chifuwa chomwe chimachokera ku minofu ya mtima yomwe ilibe magazi olemera okosijeni. Ena amamveketsa kumverera ngati kupanikizika kapena kupanikizika, ndipo kusokonezeka kumamveka pamapewa, mikono, khosi, nsagwada kapena kumbuyo kuwonjezera pa chifuwa. Mavuto a Angina angamve ngati kudzipweteka.
Angina ndi chizindikiro kusiyana ndi matenda mkati mwake. Kawirikawiri, amaimira matenda a mtima (CHD) chifukwa cha kuchepa kwa mitsempha imodzi kapena yambiri, yomwe imatchedwa ischemia.
Ranexa amagwiritsidwa ntchito pochiza angina osakwanira, koma pali mitundu yambiri ya angina, kuphatikizapo angati a microvascular, Angina a Prinzmetal, angina okhazikika, angina osakhazikika ndi angina osiyana.
Ranexa Zotsatira Zachimake
Zomwe zimachitika kwambiri za Ranexa ndizopweteka mutu, kudzimbidwa, ndi kunyoza.
Zotsatira zina zochepa kwambiri zingaphatikizepo izi:
- chizunguliro kapena kuyendayenda
- mutu
- Mlomo wouma
- kufooka
- akulira m'makutu
Kuonjezera apo, pamene mutenga Ranexa, nkofunika kumvetsera zotsatira zoopsa zotsatirazi ndikufunsani mwamsanga kwa dokotala ngati zikuchitika:
- kumverera ngati kuti mukhoza kudutsa
- kutukumula m'manja, m'magulu, kapena m'mapazi
- zipsinjo, zofulumira, kapena zopweteka mtima
- kunjenjemera
- magazi mu mkodzo
- kusamba mobwerezabwereza kapena ayi
- kupuma pang'ono
- mphutsi, kuvulaza, kupsyinjika, kupweteka, kupweteka, kapena kufooka kwa minofu
Poyamba, vuto lalikulu lokhudza Ranexa ndiloti lingathe kutalikitsa "nyengo ya QT" pa ECG (muyeso wa ntchito zamagetsi mkati mwa mtima). Mankhwala ena ndi zotsatirazi angapangitse chiopsezo chokhala ndi ziwalo zoopsa za mtima . Komabe, kufufuza mosamala kwasonyeza kuti ngoziyi ikhale yochepa kapena palibe Ranexa. Ndipotu, Ranexa tsopano wasonyezedwa kuti amachepetsa kwambiri chiopsezo chotenga ventricular arrhythmias ndi fibrillation yamagetsi .
Kuonjezera apo, anthu omwe ali ndi chiwindi (scarring) pachiwindi sayenera kutenga Ranexa, komanso anthu sayenera kutenga wort St. John ndi mankhwala ena:
- matenda a bowa
- matenda
- kudandaula
- HIV
- chifuwa chachikulu (TB)
- kugwidwa
Zotsatira:
Chaitman, BR. Ranolazine pofuna kuchiza angina osatha komanso omwe angagwiritsidwe ntchito m'maganizo ena. Kuyendayenda kwa 2006; 113: 2462.
Morrow DA, Scirica BM, Karwatowska-Prokopczuk E, et al. Zotsatira za ranolazine pa zochitika zamtima zam'tsogolo mwa odwala omwe sali opatsirana pogonana ndi syndromes. Mlandu wa MERLIN-TIMI 36 mwangozi. JAMA 2007; 297: 1775-1783.
Belardinelli L, Shryock JC, Fraser H. Njira yothandizira ranolazine kuti achepetse kutayika kwa diastolic kwa ischemia. Eur Heart J Suppl (February 2006) 8 (suppl A): A10-A13. lembani: 10.1093 / eurheartj / sui091.