Munthu sangathe kulankhula momveka bwino za kansa ya prostate popanda kudziwa ntchito ya PSA magazi . Anthu ambiri amadziwa kugwiritsa ntchito PSA kuti apeze kansa ya prostate kumayambiriro. Komabe, pali zofunikira zina zofunika kwa PSA.
Ntchito Zosiyanasiyana za PSA
PSA ili ndi maudindo osiyanasiyana. Odziwika bwino ndi owonetsa khansa. Amagwiritsidwanso ntchito popanga amuna omwe atulukira kumene.
Mwachitsanzo, amuna omwe ali otsika kwambiri ali ndi PSA pansi pa khumi . Amuna omwe ali ndi kachilombo ka HIV amakhala ndi PSA pakati pa 10 ndi 20. Amuna omwe ali ndi nkhanza ali ndi mazinga a PSA pamwamba pa 20. PSA ingagwiritsidwe ntchito kuti azindikire kuti khansara imatha pambuyo poti opaleshoni kapena ma radiation. Matendawa amatha kuchita molakwika kapena akhoza kukula mofulumira. Chochititsa chidwi ndi chakuti kuchuluka kwa PSA kukwera, nthawi yomwe imatenga nthawi iwiri, kumapereka chidziwitso chozama cha momwe khansara idzachitire zoipa m'tsogolomu. Chithandizochi chimatha kuchokera ku zozizwitsa mpaka ku radiation kapena cryotherapy ku testosterone kuchipatala mankhwala ndi Lupron komanso chemotherapy.
Kuwunika PSA Pambuyo Opaleshoni kapena Mazira
PSA ndi yofunika kwambiri pozindikira kubwezeretsa khansa pambuyo pochita ma opaleshoni kapena ma radiation. Kawirikawiri, pambuyo pa opaleshoni PSA iyenera kugwera pamtundu wosawoneka. Ngakhale kuchepa kwapang'ono kwa PSA ndi chizindikiro chotheka kuti kansa ikubwereranso. Pambuyo pa ma radiation , poganiza kuti matendawa adachiritsidwa, PSA imakhala pansi pa 1.0 nthawi zonse.
Komabe, ndi ma radiation pali zosiyana. Choyamba, miyezo ya PSA imachepa pang'onopang'ono pambuyo poizoni, nthawi zina imatenga zaka zingapo kuti ifike pamtunda wawo. Chachiwiri, kuphuka kwapang'onopang'ono ku PSA kungatheke, makamaka pambuyo pa mtundu wa mbeu. Kuwonjezeka kwa PSA kosasunthika, kotchedwa "PSA Bumps" kungapangitse patapita zaka 1 mpaka 4, kuyambitsa kudzidzimutsa za kuthekera kwa kubwereza khansa.
PSA Bump imalingaliridwa chifukwa cha kuchedwa kwa chitetezo cha mthupi mu prostate. Nkhani yabwino ndi yakuti PSA Bump ingakhale yogwirizana ndi mankhwala apamwamba. Nkhani yoipa ndi yakuti kusokoneza bump monga kubwereza kungawopsyeze amuna (ndi madokotala awo) kuti ayambe mankhwala oyenera a homoni.
Kufotokozera Mitundu Yosiyanasiyana ya Kubwereza
Ngati kugwiritsidwa ntchito kwa khansa kumatsimikiziridwa, mlingo wa PSA kawiri umasonyeza kuti chotupacho n'chosautsa. Mwachitsanzo, PSA yomwe imafuna miyezi yoposa 12 kuti iwirirenso, imayimira kubwereza kochepa kwambiri. Komabe, khansara yomwe imafuna miyezi yosachepera itatu kuti iwirirenso ndikuchita zachiwawa. Potsirizira pake, chithandizo cha matenda obwereranso chimatsogoleredwa ndi zinthu zitatu: gawo loyambitsa chiopsezo chisanayambe opaleshoni kapena ma radiation ( otsika poyerekeza ndi apakati pakati ), nthawi ya PSA yowirikiza ndi malo a khansa yobwereranso yomwe yatsimikiziridwa momwe ingathere posinthana , kapena ndi dokotala wodziwika bwino wa khansa ya prostate.
PSA Nthawi Yokamba
Kusankha mankhwala kumakhudzidwa kwambiri ndi kuchuluka kwa PSA kuuka. Mwachitsanzo, ngati PSA imadutsa m'miyezi itatu (kapena yosachepera miyezi isanu ndi umodzi), mankhwala oopsa ndi Lupron plus radiation (kapena mankhwala opangira mankhwala omwe amapezeka kale ndi ma radiation) amafunikira.
Ngati mlingo wa PSA wokhala pawiri uli pakati pa miyezi isanu ndi umodzi ndi isanu ndi umodzi, chithandizo chochepa chaukali ndi ma radiation okha, mankhwala opangira mankhwala opangira mankhwala okhaokha kapena Lupron mkati mwake angakhale ololera. Amuna ena omwe ali ndi matenda a PSA omwe ali ndi matendawa amakhala ndi chikhalidwe chomwe chimakula pang'onopang'ono ndipo palibe mankhwala omwe amafunika. Izi ndizomwe zimatenga nthawi yoposa chaka kuti PSA iwirirenso.
PSA Nthawi Yokhumudwitsa Pakati pa miyezi 6 mpaka 12
Nanga bwanji "pakati" pamene matenda omwe amapezeka nthawi zonse amawoneka kuti akupezeka kwa prostate kapena prostate fossa, node ndi zomveka bwino, gulu loyambitsa chiopsezo ndilopakatikati-pangozi ndi nthawi ya PSA yowirikiza pakati pa miyezi isanu ndi umodzi kapena 12?
Kodi munthu amene ali ndi khansara ya prostate ayenera kukhala ndi mankhwala okhaokha ndi radiation kapena cryotherapy? Nanga bwanji Lupron mkati mwake? Kodi tifunika kuchita ma radiation ndi maphunziro aifupi a Lupron? Yankho labwino kwambiri ndilokuti sitidziwa. Muzochitika zoterezi, odwala ayenera kudzidziŵa okha ndi zotsatira zake zonse zomwe zikhoza kuchitika. Kukonda kwanu ndi njira yosankhika yokwanira.
Nthawi Yopititsa PSA Nthawi Yokwiya
Nthawi yowonjezera ya PSA nthawi ziwiri, imati miyezi itatu kapena yocheperapo, ndi chisonyezero champhamvu cha mkhalidwe woopsya wa moyo. Ngakhale kuti ma scans angakhale omveka, mankhwala ayenera kukhala achiwawa. Ngakhale kugwiritsa ntchito mankhwala osayenera kungakhale koyenera. Otsopano monga Zytiga kapena Xtandi angaganizidwe. Kafukufuku wam'tsogolo akuwonetsanso kuti amuna amapulumuka bwino pamene atenga Taxotere sikisi limodzi ndi Lupron.
Gawo Loyamba Loopsa
Kawirikawiri, mankhwala ayenera kukhala amphamvu kwambiri (kuphatikizapo kuphatikiza kwa Lupron ndi miyendo ya m'mimba). Chithandizo chiyenera kutsamira ku njira yovuta-cryotherapy yokhayokha, ma radiation okha kapena Lupron yekha-ngati gulu loyambitsa chiopsezo linali Low-Risk .
Kufufuza malo a Khansa
Amuna omwe ali ndi PSA akukula pambuyo poti opaleshoni kapena ma radiation ayenera poyamba ayambe kufufuza masewera olimbitsa thupi pofuna kuyesa malo omwe ali ndi khansa. Mwamwayi, "muyezo" umawoneka ngati CT ndi MRI nthawi zambiri satha kuzindikira khansa yowonongeka, makamaka ngati PSA pansi pa 10. Kupititsa patsogolo PET kumayang'ana ndi C11 acetate kapena choline akhoza kudziwa malo omwe ali ndi matenda omwe ali ndi PSA kwambiri. Mwamwayi, zolemba za PETzi ndizatsopano zatsopano kuti inshuwalansi ingathe kupezeka.
Zowonongeka zomwe zimagwiritsidwa ntchito ndi:
- Mankhwala a Doppler ultrasound kapena multi-parametric MRI angagwiritsidwe ntchito kuyang'ana khansara yotsalira mu opaleshoni ya opaleshoni pambuyo pa opaleshoni kapena mu prostate gland mwa amuna omwe poyamba ankachitidwa ndi radiation.
- MRI yamalasi kapena CT amagwiritsidwa ntchito poyang'ana kufalikira kwa maselo a m'mimba.
- Technetium fufuzani fupa ndiyeso yachikale. Zatsopano zatsopano za F18 PET zimayang'ana chifukwa zimatha kuzindikira khansa yaying'ono kwambiri kuposa technetium bone.
Pamene Zithunzi Zisawononge Metastases Patatha Opaleshoni
Kawirikawiri, amuna omwe anali otsika kwambiri kapena omwe amatha kupha opaleshoniyo asanayambe opaleshoni ndipo omwe amayamba kukula kwa PSA ndi nthawi yowirikiza pakati pa miyezi isanu ndi umodzi ndi iwiri adzakhala ndi mankhwala abwino ochiritsira ndi salvage ndi radiation kwa prostate fossa. Momwemonso, amuna omwe akuda nkhawa za zotsatira za ma radiation angaganize kupondereza PSA ndi Lupron yomwe imayendetsedwa kwa miyezi isanu ndi umodzi. Amuna omwe ali ndi nthawi zobwereza mofulumizitsa, pansi pa miyezi isanu ndi umodzi, mwachitsanzo, ayenera kukhala ndi miyezi yambiri yomwe ili ndi Lupron, kunena miyezi 12 mpaka 18. Amuna omwe anali Oopsa kwambiri ayenera kulingalira za miyezi ya miyezi 12 mpaka 18 ya Lupron. Angaganizire kuwonjezera zowonjezera mphamvu monga Zytiga, Xtandi kapena Taxotere.
Pamene Zithunzi Zidzatha Pambuyo pa Mvula
PSA yowonjezereka pambuyo pa ma radiation, njira imodzi yotchuka kwambiri imakhala yozizira khansa yotsalayo mu prostate ndi mankhwala opangira mankhwala. Njirayi yakhala yotchuka kwambiri pakubwera kwa ma scans omwe amathandiza kuti cryosurgeon ikhale yosankha gawo limodzi la gland ndikuchiza khansara ndi mankhwala oyamba m'malo mochiza prostate yonse. Zotsatira zoyipa ndi focal cryotherapy zimakhala zovuta kwambiri poyerekezera ndi kuzizira kwambiri ndipo zimakhala zosaopsa kwambiri kuposa kuyesa prostate opaleshoni. Kuchotsa opaleshoni ya prostate pambuyo pa kutuluka kwa dzuwa sikuyenera kuganiziridwa konse chifukwa cha kusadzikuza kwakukulu komanso kupanda mphamvu.
Chinthu chinanso chomwe chilipo pa izi ndi kupereka Lupron mwachindunji. Izi zidzathetseratu matendawa ndipo izi ndizolingalira mwachidziwikire kwa amuna omwe ali ndi nthawi zowirikiza pakadutsa miyezi isanu ndi umodzi ngati gulu loyambitsa chiopsezo linali Low-Risk kapena Intermediate-Risk . Amuna omwe amabwerera kwawo kumudzi koma omwe anali pachiopsezo chachikulu amakhala opambana ndi kuyesedwa koopsa kuti athe kuchiritsa matendawa pogwiritsa ntchito mankhwala osokoneza bongo kapena kuyika mbewu m'malo mochotsa matendawa ndi Lupron okha.
Lupron Yokha Pokhapokha Opaleshoni Kapena Mafilimu Pamene Zojambula Zili Zowonekera
Monga momwe tafotokozera pamwambapa, ngati zowonongeka zatha ndipo malo akubwezereka akuwoneka ngati akumeneko, abambo amakhalanso ndi mwayi wothana ndi matenda a Lupron. Lupron yokha, komabe, imakhala ndi zotsatira zosiyana ndipo sizingawathandize konse kuchiza. Ngakhale zili choncho, matenda opatsirana kwa zaka zopitirira khumi ndi ofala. Pofuna kuchepetsa mavuto, Lupron ikhoza kugwiritsidwa ntchito mwachidule. Pulogalamu yowonjezereka imakhala ndi chithandizo chomwe chimaperekedwa kwa miyezi isanu ndi umodzi kapena 12 kenako Lupron imaletsedwa. Patapita nthawi, testosterone imachira ndipo PSA imayamba kuwuka. Lupron yachiwiri ikuyamba pamene PSA ikubweranso ku maziko oyambirira a PSA, kapena mpaka kufika pa zitatu kapena zisanu ndi chimodzi, zilizonse zotsika. Lupron yodalirika yakhala njira yowonetsera kuti azilamulira amuna omwe ali ndi PSA kubwerera kwa zaka zoposa 20. Lupron yekha ndiye njira yabwino kwambiri yothetsera vutoli ngati sitingagwire ntchito pogwiritsa ntchito radiation kapena cryotherapy.
Kuziyika Izo Palimodzi
Kotero kuti mwachidule, pazifukwa zabwino zowoneka kuti kansa sinafalikire ku nodes, mankhwala ndi mankhwala opangira mankhwala okhaokha kapena ma radiation okha ndi oyenera ngati nthawi yomwe kale idawonongeke komanso nthawi ya PSA kawiri ndi yabwino. Inde, ngakhale pamene zosawonetsera siziwonetsa metastases, kuthekera kwa zamoyo zazikuluzikulu mu nthiti za m'mimba zimayenera kuganiziridwa. Matenda a Microscopic amapezeka kwambiri mwa amuna omwe ali ndi nthawi yofulumira ya PSA kapena omwe anali Oopsa Kwambiri pa nthawi yoyamba atapezeka ndi khansa ya prostate. Muzochitika izi, kuwonjezera kwa prophylactic mitsempha yamatenda ya mitsempha yowonjezera kuwonjezera pa njira yowonjezereka ya Lupron ikuyenera.
Njira yothandizira anthu omwe ali ndi PSA kubwezeretsa ndi yovuta. Njirayi imayamba pomanga mbiri ya wodwala pogwiritsa ntchito gulu loyambitsa chiopsezo, nthawi ya PSA yowirikiza, ndi kufufuza kwasanthu. Mwamwayi, malo a khansa yosalekeza akhoza kukhala osatsimikizika, ngakhale atapanga zozizwitsa zabwino kwambiri. Ngati zili choncho, kuchuluka kwa matenda kungafunike katswiri wodziwa "kulingalira" pogwiritsa ntchito nthawi ya PSA yowirikiza ndi gulu loyambirira. Ngakhale kuti pali zovuta zonsezi komanso zosadziwika, uthenga wabwino ndi wakuti njira zosiyanasiyana zochiritsira zilipo. Kwa amuna ambiri, matendawa amatha kulamulidwa nthawi yaitali, ndipo ena amachiritsidwa. Malingaliro onse ndi chiyembekezo. Ngakhale kwa omwe sanachiritsidwe, ambiri adzatha kuteteza matenda awo kwa zaka zingapo popanda zaka.