Maselo Amng'onong'onong'onong'onong'onong'onong'onong'onong'onong'onong'onong'ana
Mankhwala otchedwa neutrophils, omwe amadziwika kuti neurocytes, ndi mtundu wa selo loyera la magazi limene limayambira pa chitetezo chathu cha mthupi. Monga mbali ya chitetezo chathu cha chitetezo cha mthupi , ma neutrophils amachita ngati mzere woyamba kuyankha, kupha mabakiteriya, mavairasi, ndi tizilombo toyambitsa matenda.
Mankhwala otchedwa neutrophils angathenso kutchulidwa ngati phagocytes ( phago- kutanthawuza kudya ndi -kutanthauza tanthauzo la selo) pamene akuteteza thupi mwa kumeza zamoyo.
Zimapangidwa m'kamwa ndi fupa la magawo 50 mpaka 70 peresenti ya maselo oyera.
Kodi Neutrophils Amatani?
Monga maselo otetezeka a chitetezo cha m'thupi, ma neutrophils ali ndi motility yapamwamba (kutanthauza kuti amatha kusuntha pokhapokha) ndipo amatha kuzungulira wothandizira kupha. Kuphatikiza pa kumeza tizilombo toyambitsa matenda, tizilombo toyambitsa matenda timatha kumasula zinthu za cytotoxic (kupha maselo) zomwe zimapangitsa kuti thupi likhale losavuta.
Mankhwalawa amatha kupeza nyama zawo pogwiritsa ntchito njira yotchedwa chemotaxis momwe amadziwira mankhwala omwe amachotsedwa kapena kudula ndikupita ku "fungo" ilo mosavuta.
Izi sizikusiyana ndi mzere wachiwiri wogwiritsira ntchito chitetezo chomwe chimapanga maselo ofanana ndi kupha tizilombo toyambitsa matenda ndi tizilombo tokha. Kachilombo koyambitsa chitetezo, mosiyana, chimapha osati mwachindunji, kuyambitsa chirichonse chimene "sichimva" moyenera.
Matenda a tizilombo amayankha matenda omwe ali mkati mwa thupi komanso pamwamba pa khungu.
Pus , imodzi mwa mankhwala okhudzana ndi matenda a khungu, makamaka amapangidwa ndi dead neutrophil, mabakiteriya, ndi maselo a khungu.
Zomwe Tizilombo Tomwe Tili ndi Neutrophil Tikutiuza
Mazira otchedwa Neutrophils amawerengedwa monga gawo la kuyesa kwathunthu kwa magazi (CBC) . Chiyeso china, chotchedwa WBC kusiyana , chimafotokoza kuchuluka kwa mtundu uliwonse wa maselo oyera a magazi mu chitsanzo cha magazi, kuphatikizapo neutrophils, lymphocytes, monocytes, basophils, ndi eosinophils.
Panthawiyi, chiwerengero cha neutrophil (ANC) chimatiuza kuchuluka kwa maselo omwe ali m'magazi omwe ali ndi "maselo" omwe ali pakati pa 1800 ndi 7800 maselo pa microliter (mL).
Chiwerengero cha neutrophil chokwanira, chomwe chimatchedwa neutrophilia , chingayambitsidwe ndi matenda alionse, kupwetekedwa mtima, kapena kutupa komwe kumayambitsa chitetezo cha mthupi. Neutrophilia ndi yowonjezereka ndi zowonjezereka, kuyaka kwakukulu, mitundu ina ya khansa ya m'magazi, ndi chikhalidwe chirichonse chimene chimayambitsa kutupa kwakukulu (monga matenda a mtima).
Mosiyana ndi zimenezi, chiŵerengero chochepa, chomwe chimatchedwa neutropenia , chingayambitsidwe ndi sepsis , chemotherapy, chithandizo cha ma radiation, ndi matenda enaake omwe amadziwika nawo. Kwa anthu ena, neutropenia ikhoza kukhala yachilendo (yopitirira ndi yotsalira) pamene ena adzakhala osakhalitsa (kawirikawiri akuyang'ana matenda kapena mankhwala osokoneza bongo).
Kuwunika Neutrophils mu Chithandizo cha Khansa
Panthawi ya chithandizo cha khansa , kuwerengera kotheratu kwa neutrophil kumafufuzidwa kawirikawiri kuti mudziwe momwe chitetezo cha mthupi chikuyankhira ku chipsinjo cha ma radiation kapena chemotherapy. Neutropenia ndi yowonongeka m'madera amenewa ndipo ikhoza kusankhidwa ngati:
- Nthenda yotchedwa neutropenia yochepa (ANC pansi pa 1500 maselo / mL) yomwe imakhala ndi chiopsezo chochepa cha matenda.
- Neutropenia yochepa (ANC pakati pa 1000 ndi 500 maselo / mL) yomwe imayambitsa matenda.
- Neutropenia yoopsa (ANC yosakwana 500 maselo / mL) yomwe imayambitsa matenda.
Ngati bungwe la ANC likudumpha pamtunda pafupifupi maselo 500 / mL, dokotala wanu angapereke mankhwala kuti azitha kuonetsetsa kuti maselo a neutrophil ndi othandizira komanso akhoza kupereka mankhwala omwe amachititsa kupewa matenda aakulu.
> Chitsime:
> Ochimwa, L .; Hiemstra, I .; Kuijsper, T .; et al. "Mapuloteni a khansa." Immunol Rev. 2016; 3273 (1): 312-28.