Mayesero Akugwiritsidwa Ntchito Mu IBD Management ndi Covered By Companies Companies
Madokotala amagwiritsa ntchito mayesero osiyanasiyana kuti awone zomwe zikuchitika mkati mwa anthu omwe ali ndi matenda opatsirana (IBD) . Kugwiritsa ntchito testos endycopy kuti muyang'ane mkati mwa matumbo aang'ono kapena aakulu ndi njira yabwino kwambiri yodziwira, koma ming'oma ikhoza kuchitidwa kambirimbiri ndipo madokotala amafunikira zambiri mobwerezabwereza kuposa izo. Ndipamene mayeso a fecal calprotectin angakhale othandiza chifukwa, mosiyana ndi njira yoperekera mapuloteni, sizowononga koma akhoza kupereka zina zomwe zingathandize kupanga chisankho.
Calprotectin ndi mtundu wa mapuloteni omwe amapezeka makamaka m'magawo ena oyera a maselo oyera omwe amatchedwa neutrophil granulocytes ndi mitundu ina ya maselo oyera a m'magazi. Chiwerengero cha calprotectin muzitsulo chikhoza kuyesedwa, ndipo zapezeka kuti anthu omwe ali ndi IBD amakonda kukhala ndi calprotectin ochulukirapo pamsana wawo (nkhani zamtundu) kuposa anthu omwe alibe IBD.
Mfundo Zachidule Zokhudza Matenda a Fecal Calprotectin (Kapena Osowa)
- Calprotectin ndi mapuloteni ambiri omwe amapezeka m'maselo oyera a magazi omwe amakhala ambiri mwa anthu omwe ali ndi IBD.
- Mayeso a fecal calprotectin amachitika pa sampula.
- Makampani ambiri a inshuwalansi adzaphimba mayeso a fecal calprotectin kuti athetse IBD.
- Pali kusiyana pakati pa maonekedwe a "fecal calprotectin" kuyambira munthu ndi munthu.
- Mafunde a Fecal calprotectin akhoza kukhala apamwamba ngakhale kuti palibe zizindikiro zoopsa za IBD.
Chifukwa chiyani anthu omwe ali ndi IBD ali ndi calprotectin yambiri muzovala zawo?
Kafukufuku wasonyeza kuti kusunga mlingo wa fecal calprotectin mu sitolo kumapindulitsa mu kuyang'anira IBD.
Izi ndi zotsatira za matenda a Crohn kapena ulcerative colitis omwe amachititsa kutupa m'magazi . Pamene kutupa kumachitika mu mucosal wosanjikiza kwa matumbo, pamene maselo a magazi akuwonjezeka nambala kuti amenyane nayo. Maselo oyera a m'magazi akhoza kuwonongeka, zomwe zikutanthauza kuti amasula zomwe zili mkati kuti ateteze maselo a thupi kuti asatuluke.
Mkati mwa maselo oyera a magazi ndi calprotectin (komanso mankhwala ena ambiri) ndipo pakakhala calprotectin yambiri muchitetezo, ndizosangalatsa kuti pali kutupa kwambiri m'matumbo.
Mayeso a Calectectin a Fecal Achitidwa Bwanji?
Kuyeza fecal calprotectin kawirikawiri kumakhala koyesedwa kosavuta kuchita chifukwa zonse zomwe zimafuna ndi chitsanzo chachithunzi, chinthu chomwe chimakhala chosavuta kubwera popanda khama. Pamene wodwala akupemphedwa kuti apereke sampulo yachithunzi, zikutanthawuza kutenga chotupa mu chidebe chosabalalitsa ndikutembenuzira ku labu, kaya kuchipatala, ku ofesi ya dokotala, kapena ku malo ogona. Mbali ya fecal calprotectin nthawi zambiri imakhala yapamwamba panthawi yamakono ndipo imatsikira panthawi yamakhululukidwe, koma mayesero sali olephera. Pali kusiyana pakati pa magulu a calprotectin ndi munthu wina ndipo pali kusiyana pakati pa munthu ndi munthu. Komabe, ndi chida china chomwe gastroenterologist chingagwiritse ntchito kuthandiza anthu omwe ali ndi IBD kukhala patsogolo pa kusintha kwa matenda awo.
Chifukwa chiyani Calectectin ya Fecal Yothandiza mu IBD?
Calprotectin ndi othandiza pa zifukwa zingapo: Choyamba ndi chakuti pamene chipezeka mu sitolo, chimakhazikika kwa nthawi yaitali. Kwa nthawi yaitali masiku asanu ndi awiri, mlingo wa calprotectin mu sampula yachitetezo udzakhalabe wofanana, kuti chiyeso chikhale chosavuta kuchita.
Kupindula kwina ndikuti fecal calprotectin mlingo amatha kupezeka ngakhale ngakhale pang'ono.
Kafukufuku wambiri wasonyeza kuti anthu omwe ali ndi IBD ali ndi calprotectin yokwanira m'magulu awo poyerekeza ndi anthu omwe alibe IBD (anthu abwinobwino mu maphunzirowa amatchedwa kulamulira). Pofuna kudziwa kuti mayeserowa ndi othandiza, maphunziro adachitidwa omwe amayeza kuchuluka kwa fecal calprotectin m'magulu mwa anthu omwe ali ndi IBD, omwe adatsatiridwa ndi testoscopy kuti ayang'ane momwe mazingawo akufanana ndi zomwe zikuchitika m'magazi. Chimene ofufuza adapeza chinali chakuti anthu omwe ali ndi IBD anali ndipamwamba kwambiri ma fecal calprotectin m'mipandoyi inakhalanso ndi kutupa kapena zilonda zomwe zinayambitsa IBD kwinakwake m'magawo awo.
Anthu omwe amaphunzirawo sanali ndi zizindikiro zoopsa kwambiri za IBD, ngakhale kuti ma fecal calprotectin anali otsika kwambiri. Izi zinali zowona makamaka mu ulcerative kolitis kuposa momwe zinaliri mu matenda a Crohn. Izi zikuwunikira phindu lina la mayeso a mchere wa calprotectin, chifukwa amatha kupereka chenjezo loyambirira kuti kutupa kwina kukuchitika m'magawo am'thupi ngakhale zizindikiro zisanayambike.
Poyerekeza calprotectin mu mpando, akatswiri amatha kuyamba njira yopezera IBD mwa wodwalayo, kapena kuyesa ntchito ya matenda m'thupi lomwe lapezeka ndi IBD. Lingaliro ndilokuti mayesero ophweka, omwe siwowopsya chifukwa amachitika pa chitseko, amatha kuwunikira kufunikira kosathako (monga sigmoidoscopy kapena colonoscopy ) nthawi zina ndikuwonetsa kufunikira koyezetsa mapepala a endoscopy kwa ena. Fecal calprotectin mayesero sangasinthe malo operecopy, koma angathandize madokotala ngati chida chowonetsera, kuti adziwe bwino ngati pakufunika kuyesa kutsatila.
Kwa ana omwe ali ndi IBD fecal calprotectin angakhale othandiza kwambiri. Pogwiritsa ntchito mayesowa, pali dokotala wodalirika kuti adziŵe ngati zizindikiro zikhoza kubwera kuchokera ku IBD kapena ayi, popanda kuyeza mayesero ovuta monga ngati mapulogalamu osungirako mankhwala kapena mayesero omwe amaphatikizapo ma radiology monga kanema wa CT.
Mafunde a Fecal calprotectin angakhalenso othandiza kwa anthu amene akufuna kupeza matenda ndi IBD ali osakaniza. Fecal calprotectin ikhoza kulamulidwa ndi dokotala wa chisamaliro chapadera kapena internist ndipo ngati icho chikukhala chokwera, chomwe chingayambitse kutumiza kwa gastroenterologist kuti apitirize kuyesa.
Kodi Pali Zowonjezera ku Fecal Calprotectin Assay?
Imodzi mwa zovuta za kuyesa fecal calprotectin ndi zotsatira zabodza kapena zotsatira zabodza, ngakhale zotsatirazi si zachilendo. Wodwala angakhale ndi IBD kapena akhoza kutupa ku IBD, koma fecal calprotectin mlingo sangakhale wapamwamba kwambiri. Izi zikutanthawuza kuti pali kutupa komwe kumachitika m'magazi am'mimba koma zotsatira za mayeso zimabwereranso ndi makina otsika a calprotectin (ngakhale izi sizowoneka). Zolakwa zingakhale zovuta makamaka kwa ana ndi achinyamata, omwe amapanga gawo lalikulu la odwala omwe ali ndi IBD.
Kodi mayeso a Fecal Calprotectin Amalembedwa Ndi Inshuwalansi?
Ma inshuwalansi ena amatha kuyesa matenda a Crohn's disease ndi ulcerative colitis chifukwa chawonetseredwa kuti ndiwothandiza. Mtengo wa mayesowa udzakhala wotsikirapo kusiyana ndi mapeto osungirako mankhwala kapena CT scan. Pakhoza kukhala makampani a inshuwalansi omwe samapereka chiyeso ichi koma mwachizolowezi chifukwa alibe mbiri yakale ya mayesero ena, ndipo makampani a inshuwalansi amayamba kuchepetsedwa kuti ayambe kusintha. Komabe, nthawi zonse pali ndondomeko, ndipo Crohn's ndi Colitis Foundation ili ndi chidziwitso chomwe dokotala angachigwiritse ntchito kupempha kufotokozera kwa mayeso kuchokera kwa inshuwalansi.
Chidziwitso Chochokera
Nthendayi ya mlingo wa calprotectin imakhala yochepa kwambiri mu IBD dziko kuposa, kunena, colonoscopy imachita. Komabe, ndi mayesero othandiza, makamaka chifukwa sichifuna chilichonse chapadera, ngati chongoganizira kapena tsiku lochoka kuntchito, kuti lichitike. Osati dokotala aliyense akhoza kulamula mayesowa, choncho ndibwino kufunsa ngati kuli koyenera nthawi zina. Makampani a inshuwalansi nthawi zambiri amawaphimba, makamaka ngati ali wodwala ndi IBD (amadziwa kuti ndi otchipa kusiyana ndi mayesero ena). Pali zina zomwe fecal calprotectin sizingabwererenso ndi magulu akuyembekezeredwa, koma izi sizowonekera.
> Zotsatira:
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> Roda G, Caponi A, Benevento M, ndi al. "Njira Zatsopano Zamakono Zopangira Matenda a Biomarker Akupeza Matenda Opatsirana Opunduka." Inflamm Bowel Dis . 2010; 16; 7: 1239-1246
> Van Rheenen PF, Van de Vijver E, Wokondedwa V. "Faecal calprotectin pofuna kufufuza odwala omwe akuganiza kuti ndi zotupa zotupa: matenda opatsirana." BMJ . 2010 Jul 15; 341: c3369.
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