Ngakhale kuti melatonin ndi hormone yomwe ubongo umabala mwachilengedwe, mukhoza kudziŵa bwino ngati njira yothetsera vutoli komanso kusokonezeka kwagona. Ubongo wa pineal gland umabisa melatonin mu maola 24. Amatulanso khungu, retina la diso ndi mafupa.
Mu chilengedwe, kupanga mapiri a melatonin usiku, ndipo amaletsedwa ndi kuwala kwa tsiku.
Ndi mdima umabwera kuchuluka kwa melatonin, kumabweretsa chidziwitso ndi bata-ndikuyembekeza, kugona. Zinthu zina komanso mahomoni monga serotonin ndi ofunika kwambiri, komabe pakuwongolera kugona kwa thupi.
Kugona, Melatonin ndi Khansa
Zofukufuku zosonyeza kugwirizana pakati pa zovuta, kugona kwa melatonin ndi khansa kwachititsa chidwi kwambiri. Ntchito yogwira ntchito usiku imalumikizidwa ndi kutopa ndi kusowa tulo, m'munsi mwa melatonin m'magazi, ndi matenda osiyanasiyana kuphatikizapo matenda a mtima, matenda a kagayidwe kake-ndi khansa ya mitundu yosiyanasiyana.
Shift Ntchito ndi Khansa
Zonsezi mwazitsulo za ogwira ntchito zosuntha zinachititsa asayansi ena kudzifunsa ngati melatonin ingathandize kuteteza anthu ku matendawa. Kafukufuku wina wa ku Canada mwa amuna ogwira ntchito ogwira ntchito osamalira ntchito usiku anapeza kuti ntchito yamadzulo ija inali yogwirizana kwambiri ndi mitundu yosiyana ya khansa, kuphatikizapo sanali Hodgkin lymphoma .
Maphunziro a mtundu uwu ayang'ane kuti awone momwe chinthu chofala chimagwirizanitsa ndi china chake-iwo "amagawanika," kapena otchedwa matenda a chilengedwe.
Deta zochokera ku zofanana zomwe zikuwoneka ngati zikugwirizana ndi zomwe zingatheke ku melatonin komanso kugona kwa khansara ya m'mawere . Amayi omwe amagwira ntchito usiku usiku amakhala ndi 19 mpaka 51 peresenti yowonjezera ngozi ya khansa ya m'mawere. Ponena za kansa ya prostate , kafukufuku wina anapeza kuti amuna omwe ali ndi khansara ya prostate anali ndi makina otsika kwambiri a melatonin poyerekezera ndi amuna omwe analibe khansa koma omwe amatha kusokoneza bongo, benign prostatic hyperplasia.
Palibe mwa maphunziro awa ndiwo mtundu umene ungasonyeze chifukwa ndi zotsatira, komabe. Zomwe zimapezeka zimapangitsa kuti pakhale zoonjezera, koma sizikuthandizira kugwiritsa ntchito melatonin pofuna kupewa khansa.
Dongosolo la Zanyama ndi Zipangizo
Maphunziro a Laboratory amasonyeza kuti melatonin ndi antioxidant wamphamvu yomwe imalimbikitsa ziwalo zina za chitetezo cha mthupi, koma sichidziwika ngati zotsatirazi zimachitika mwa anthu. Melatonin ikuwoneka kuti imalepheretsa maselo ena a khansa kukula pamene akugwiritsidwa ntchito mwachindunji ku maselo awa mu ma laboratory ndi pa maphunziro a nyama-zotsatirazi zawoneka mu khansa ya m'mawere ndi melanoma.
Zofukufuku mwa anthu, komabe, sizinapangitse kuti munthu amwe mankhwala.
Malingana ndi deta ya in vitro, asayansi ena aganiza kuti kutengeka kwa chitetezo cha mthupi, ngati muli mu vivo, sikungakhale chinthu chabwino nthawi zonse. Mwachitsanzo, kupeweratu thupi kwa odwala matenda a khansa ya m'magazi kapena lymphoma kukhoza kukhala kosabala zipatso, chifukwa khansa imeneyi imakhudza maselo a chitetezo cha mthupi m'matumbo, mafupa ndi magazi.
Melatonin mu zitsanzo zoyesera zawonetsa katundu wina wotsutsa khansa, ndipo kugwedezeka kwa chitetezo cha mthupi kumalingaliridwa. Kafukufuku wa Miller adanena kuti melatonin ikugwira nawo ntchito yotsegula ma lymphocytes ndi monocytes / macrophages-mitundu yosiyanasiyana ya maselo oyera.
Mankhwala am'mimba ndi khansa omwe amachokera ku lymphocytes.
Mu vitro, melatonin ikuwoneka kuti ikugwira ntchito yowononga thupi la T-selo , kuyambitsa maselo ena omwe amatchedwa cytokines; Zingathenso kuteteza njira zowononga maselo a magazi kuchokera ku mankhwala oopsa a chemotherapy ndi radiotherapy , malinga ndi kafukufuku wina wa 2001 wa Maestroni.
Apanso, sizidziwika ngati melatonin idzakhala ndi zotsatirazi mu vivo, makamaka odwala.
Melatonin mu Chithandizo cha Khansa
Zomwe zimadziwika ndi melatonin zikagwiritsidwa ntchito kwa anthu omwe ali ndi khansa. Gulu limodzi la asayansi linaganizira mosamala zotsatira za melatonin pamene amaperekedwa pamodzi ndi mankhwala a chemotherapy, radiotherapy, chisamaliro chothandizira, ndi chisamaliro cholumala kwa odwala omwe ali ndi zotupa zamphamvu - osati khansa ya m'magazi kapena mitsemphama.
Mu phunziro ili, melatonin sinali yogwirizana ndi kuwonjezeka kwa poizoni kapena kuchepetsedwa kwa mankhwala, ndipo zinkawoneka kuti zimathandiza ndi zotsatira zina za mankhwala a chemotherapy.
Melatonin m'magulu a khansa ya magazi
Ngakhale zocheperako zimadziwika pankhani ya melatonin mwa anthu omwe ali ndi khansa ya magazi monga khansa ya m'magazi ndi lymphoma . Mndandanda wamakono wa National Comprehensive Cancer Network (NCCN) pa mafupa ena omwe si a Hodgkin, omwe ndi amodzi kwambiri a mtundu wa lymphoma, samaphatikizapo ndondomeko pa ntchito ya melatonin.
Chiwerengero cha kafukufuku amene akufalitsidwa panopa pa melatonin yomwe imayenderana ndi lymphoma ikuwonekera kuchokera ku data ya vitro ndi ya nyama, osati mayesero a zachipatala.
Nthawi zonse muzilankhulana ndi dokotala wanu za kutenga mankhwala enaake, monga zowonjezereka zingakhale ndi zotsatira zovulaza ndi kuyanjana kwa mankhwala.
Mawu ochokera:
Melatonin yagwiritsidwa ntchito mosamala ngati anthu ambiri ogona, komanso ali ndi udindo wothandizira kusokoneza mitundu yosiyanasiyana.
Melatonin ndi mankhwala a chilengedwe, koma zinthu zachilengedwe zikhoza kukhala ndi zotsatirapo ndi kuyanjana kosaganizidwe. Melatonin angagwirizane ndi mankhwala osiyanasiyana, kuphatikizapo mankhwala osokoneza bongo, antidepressants, mankhwala a mahomoni, ndi ena.
Lankhulani ndi dokotala wanu za momwe mumagwiritsira ntchito melatonin kapena zina zowonjezerapo-makamaka ngati mukuchiritsidwa ndi khansa kapena matenda ena onse.
Zotsatira
Brown SB, Hankinson SE, Eliassen AH, et al. Kugonjetsedwa kwa Uraton Melatonin ndi Kuopsa kwa Khansa ya M'bwere mu Thanzi la Achirepere Phunziro II. Am J Epidemiol . 2015; 181 (3): 155-162.
Sigurdardottir LG, Markt SC, Rider JR, et al. Mipata ya Melatonin ya Urinary, Kusokonezeka Kogona, ndi Kuopsa Kwa Khansa ya Prostate mwa Amuna Okalamba. Urology wa ku Ulaya . 2015; 67 (2): 191-194.
Zamfir Chiru A, Popescu C, Gheorghe D. Melatonin ndi khansa. J Med Life. 2014; 7 (3): 373-374.
Parent MÉ, El-Zein M, et al. Ntchito yausiku komanso chiopsezo cha khansa pakati pa amuna. Am J Epidemiol. 2012; 176 (9): 751-9.
Miller SC. Udindo wa melatonin mu kuyambitsa chithunzithunzi: Kugwiritsa ntchito khansa. Int J Exp Pathol . 2006; 87: 81-87.
Sánchez-Hidalgo M, Lee M, wa la Lastra CA, et al. Melatonin imalepheretsa kufalikira kwa maselo ndipo imapangitsa kuti maselo a caspase agwiritsidwe ntchito komanso apoptosis mu maselo oopsa a mitsempha ya lymphoid. J Pineal Res. 2012 Nov; 53 (4): 366-73.
Maestroni GJ. Matenda opangidwa ndi thupi la melatonin. Ofufuza Opin Ofufuza Mankhwala Osokoneza Bongo. 2001; 10: 467-476.
Sadeghniiat-Haghighi K, Aminian O, Pouryaghoub G, Yazdi Z. Zotsatira zogwira mtima komanso zosokoneza za melatonin mu aamuna ogwira ntchito: odwala awiri omwe ali ndi kachilombo kosaoneka bwino. J Circadian Rhythms . 2008; 6: 10.
Persengiev SP, Kyurkchiev S. Kusankhidwa kwa melatonin pa kuchuluka kwa maselo a lymphoid. Int J Biochem. 1993 Mar; 25 (3): 441-4.
Dauchy RT, Xiang S, Mao L, et al. Kusokonezeka kwa Circadian ndi Melatonin Poonekera Kuwala pa Usiku Kumayambitsa Kutsutsana kwa Intrinsic kwa Tamoxifen Therapy mu Breast Cancer. Kafukufuku wa khansa . 2014; 74 (15): 4099-4110.
Paredes SD, Rancan L, Kireev R, et al. Malatonin Zotsutsana pazithunzithunzi Zomwe zimapangitsa munthu kupweteka ndi kupweteka kwa apoptotic Sekondi kwa Ischemic Brain Kuvulala Kuchokera ku Middle Cerebral Artery Blockade mu Aging Rats. BioResearch Kutsegula . 2015; 4 (1): 407-416.
Malangizo a NCCN pa Osati Hodgkin Lymphoma. Version 1.2016. Inapezeka mu February 2016.