Kuthamanga kwa maso mwamsanga kugonana kugonana ndi melatonin
REM (kuyenda mofulumira kwa diso) kugona kwa khalidwe la kugona kungakhale kokhumudwitsa ngati sikuli koopsa ndipo kwakhala kokhumudwitsa kuchiza. Kodi taphunzira chiyani za udindo wa mankhwala owonjezera a melatonin pochiza matendawa?
REM Behavior Disorders (RBD)
Mwina simunamvepo za vuto la khalidwe la REM (RBDs) , koma anthu ambiri amadziwa zitsanzo zina.
Ngati mumadziwa za wina yemwe akulota za kuukiridwa ndi munthu kapena nyama ndipo adadzuka akuwombera mwamuna wawo, mwamvapo chitsanzo. Ngati inu kapena munthu wina yemwe mumadziwa kuti wapita chifukwa cha maloto anu (pamene mukugona), zikhoza kukhala chikhalidwe chodziwika kuti RBD.
Kugona ndi RBD
Mu usiku wamba wa kugona, timadutsa m'magulu osiyanasiyana ogona. Kugona kwa REM (ndi REM kukuyendetsa kugona mofulumira) ubongo umagwira ntchito. Ndi gawo ili la tulo lomwe nthawi zambiri limagwirizanitsidwa ndi maloto. Pamene tili m'tulo la REM timakhala osagwiritsa ntchito minofu yathu, kupatulapo minofu ya maso komanso ndithu kuti tizilombo toyambitsa matenda (kotero timapuma kupuma). Ngati minofu yathu yina ilibe ziwalo panthawi imeneyi, tingathe kukhala ndi malingaliro athu. Zochita izi zimatchedwa mavuto a khalidwe la REM.
Anthu ambiri amakumana ndi REM akugona pafupi ndi mphindi 90 iliyonse. Kumayambiriro kwa usiku kugona tulo nthawiyi ndi yochepa koma imakhala pang'onopang'ono pamene tikuyandikira kudzuka m'mawa.
Kugona Kwambiri Kwambiri kumachitika mu gawo lachitatu la kugona kwa usiku.
REM Yomwe Imakhala Kugona Matenda Ovuta
Mwamwayi, maloto ambiri okhudzana ndi RBD ndi osasangalatsa ndipo amaphatikizapo kuloĊµerera kapena kuukira kwa mawonekedwe ena. Pamene malotowa amamasuliridwa muzochita, makhalidwe amatha kuphatikizapo kukopa, kukwapula, kugwa pa kama, kulankhula, kapena kulira.
Izi zikachitika zimatha kuvulaza munthu amene ali ndi RBD kapena ogonana nawo. RBD imakhudza pafupifupi 1 mwa anthu 200 ndipo imakhala yowonjezeka kwambiri pakati pa amuna a zaka zapakati, Yakhala yogwirizana ndi matenda a Parkinson ndi ziwalo zina zamaganizo, komanso kuchotsa mowa, ndipo zingachitenso ngati mankhwala osokoneza bongo amachititsa kuti mankhwalawa asokonezeke. Ikuwonetsanso kwa achinyamata omwe ali ndi vutoli .
RBD ikhoza kukhala yoopsa. Phunziro limodzi, anthu 32 mpaka 64 mwa anthu 100 alionse amene akudwala RBD anavulaza okha kapena bedi lawo. Pa 7 peresenti izi zidaphatikizapo kuphwanya fupa. Kawirikawiri, RBD yayambitsa kusokoneza kapena kuvulazidwa kwa ubongo. Ngakhale kuti kuvulala kwakukulu ndipadera, ngakhale RBD popanda kuvulala kungayambitse mavuto aakulu kwa onse omwe akukhudzidwa komanso kwa ogonana nawo.
Melatonin ndi Kugona
Melatonin ndi hormone yachilengedwe yomwe imapezeka pa-counter. Amagwiritsidwa ntchito kwambiri kugwiritsira ntchito matenda a circadian matenda , mavuto osagwirizana ndi tulo, jet, ndi zizindikiro za menopausal. Iyenso yafufuzidwa chifukwa cha zotsatira zake pa matenda a Alzheimer's , komanso chifukwa cha kuthekera kwake popewera ndi kuchiza khansa .
Melatonin imapangidwa mwachibadwa m'kati mwa ubongo pa ubongo. Mipingo yambiri imabisidwa mumdima ndipo ichi ndi chifukwa chotsatira kuti tigone m'chipinda chamdima ndi magetsi. Kuwonjezera pa kuwala usiku, matenda ndi msinkhu zingachepetse kuchuluka kwa chilengedwe. Kusungunuka kwa Melatonin kumayamba madzulo ndikukwera pakati pa usiku (pakati pa 2 ndi 4 am).
Kodi melatonin imakhala ndi ntchito yosayembekezereka pochiza matenda a REM (RBD) ?
Kugwira Ntchito kwa Melatonin kwa Matenda a Kuthyoka A REM
Melatonin yafufuzidwa chifukwa cha ntchito yake yothandizira RBD, ndipo, pakalipano, tsopano ikuvomerezedwa mzere woyamba (patsogolo pa china chirichonse) pa chithandizo cha matenda awa ogona.
Zikuwoneka kuti zimakhudza kwambiri matendawa kuposa Klonopin (clonazepam), mankhwala oyamba omwe analandilidwa kale. Sikuti kampani ya melatonin imagwira ntchito bwino, ndi yotetezeka kwambiri kuposa Klonopin.
Mu maphunziro, melatonin imachepetsanso minofu pa nthawi ya kugona kwa REM (anthu amasunthira pang'ono panthawi imeneyi) zomwe zikutanthawuza kuchepetsa luso lochita maloto. Izi zikuwoneka mu maphunziro omwe apeza kuti melatonin imachepetseratu bwino khalidwe la REM.
Zindikirani kuti mlingo wa melatonin umene umagwiritsidwa ntchito pochizira RBD nthawi zambiri umakhala wapamwamba kusiyana ndi omwe amagwiritsidwa ntchito monga chithandizo cha kugona, ndi mlingo wa 3 mg mpaka 12 mg wogwiritsidwa ntchito pa maphunziro omwe adawunika.
Mavitamini a Melatonin amawoneka ngati opambana kwa anthu omwe ali ndi matenda a Parkinson, matenda a Demokarasi a Lewy, ndi machitidwe ambirimbiri omwe amachititsa kuti azikhala ndi RBD.
Momwe Melatonin Angagwiritsire Ntchito Potengera RBD ndi Matenda a Kugona?
Ngakhale kuti zathandiza kuchepetsa mavuto a khalidwe la REM, sitidziwa bwinobwino momwe melatonin imagwirira ntchito. Melatonin ikuwoneka ngati chizindikiro mu matupi athu omwe amayang'anira kugona kwathu ndi kudzuka kumayendedwe a kuwala ndi mdima m'malo athu.
Melatonin ikhoza kuthandizira kugwirizanitsa machitidwe ogona kuti amalimbikitsa kugona. Zikuwonekeranso kuti akuthandiza kugona bwino. Pa mlingo wa maselo, GABAergic inhibition (kutetezedwa kwa m'modzi mwa akatswiri a ubongo mu ubongo) kungathandize.
Ubwino wa Melatonin
Imodzi mwa ubwino waukulu wa ntchito ya melatonin ndi yakuti ili ndi zotsatira zochepa. Poyerekeza ndi Klonopin, melatonin imakhala ndi zotsatira zochepa. Komanso sizingatheke kuti ziyanjane ndi mankhwala ena omwe munthu akuwatenga.
Zowononga ndi Zotsatira Zotsatira za Melatonin
Monga tanenera kale, mlingo wa melatonin umene umagwiritsidwa ntchito mu maphunziro pofufuza momwe amagwiritsira ntchito mu vuto la khalidwe la REM wakhala wapamwamba kuposa omwe amagwiritsidwa ntchito chifukwa cha kusoĊµa tulo kapena kupopera. Zotsatira zoyipa zomwe zimapezeka pazifukwazi zimaphatikizapo kugona m'mawa (29 peresenti), kusokonezeka kuganiza (12 peresenti), mavuto olemera (8 peresenti), nkhanza (8 peresenti) ndi kugwira ntchito kwa kugonana (8 peresenti).
Pansi pa Kugwiritsiridwa kwa Melatonin kwa Matenda a Sleep Sleep
Melatonin imawoneka kuti ndi njira yabwino komanso yosavomerezeka yothandizira mavuto a khalidwe la REM kusiyana ndi Klonopin, ngakhale kuti Klonopin yasonyezedwa bwino. Melatonin ikuwoneka kuti ikugwira ntchito bwino, ndipo mwinamwake imayamba kumayambitsa mchitidwe wosalongosoka osati kungodziwa zizindikirozo basi. Anthu ambiri omwe amapezeka kuti ali ndi RBD ali ndi zaka 50 kapena kuposerapo, ndi matenda ena, ndipo melatonin sichitha kuyanjana ndi mankhwala ena kuposa Klonopin. Zonsezi, kugwiritsidwa ntchito kwa melatonin kumapereka njira zothandiza komanso zosatetezera zothana ndi vuto la vuto la maso la kugonana mofulumira.
> Zotsatira:
> Howell, M., ndi C. Shenk. Kuthamanga kwa Osowa Mwamsanga Kugona Matenda a Khalidwe. Kupititsa patsogolo . Kusinthidwa 07/24/17.
> McGrane, I., Leung, J., St Louis, E., ndi B. Boeve. Thandizo la Melatonin la REM Sleep Sleeping Disorder: Kukambitsirana Kwambiri kwa Umboni. Kugona Mankhwala . 2015. 16 (1): 19-26.