Ngakhale kuti palibe mankhwala a Parkinson , pali mankhwala ambiri omwe angathandize kuthetsa zizindikiro za matendawa.
Kugwiritsidwa ntchito nokha kapena (mochuluka) kuphatikiza, mankhwalawa amalola kuti thupi lanu liziyenda bwino, zomwe zimakuthandizani kuchita zomwe mukufuna kapena zoyenera kuchita.
Anthu omwe ali ndi Parkinson amadzipindulitsa okha podziwa momwe mankhwalawa amathandizira, ndi phindu lanji limene angapereke, komanso zotsatira zake zomwe zingayambitse. Ndiye, pamene dokotala akusonyeza kusintha kapena kuwonjezera pa mankhwala omwe mukuwutenga, mukhoza kupanga chisankho chodziwika pa chithandizo chanu.
Dopamine Replacement Therapy
Levodopa , kapena L-dopa monga momwe zimadziŵika, zimatengedwa kuti ndizogwiritsidwa ntchito kwa golide kwa Parkinson komanso ndi mankhwala omwe amagwiritsidwa ntchito kwambiri.
Mankhwalawa amatembenuzidwa kukhala dopamine ya neurotransmitter mu ubongo, yomwe imabweretsanso zopereka za dopamine zomwe zatayika pamene matendawa akupita. Pochita zimenezi, L-dopa imathandiza kuti zizindikiro za matenda a Parkinson zikhale bwino.
L-dopa ndi othandiza koma ingayambitse mavuto ena, kuphatikizapo kayendetsedwe kadzidzidzi (kotchedwa dyskinesias). Kawirikawiri amauzidwa mothandizidwa ndi mankhwala ena otchedwa carbidopa omwe amachepetsa zotsatira zake.
Dopamine Agonists
Mankhwalawa amagwiritsidwa ntchito kwambiri chifukwa cha mankhwala a Parkinson ndi mankhwala otchedwa dopamine agonists. M'malo moika dopamine mu ubongo wanu, mankhwalawa amanyengerera ubongo wanu kuti aganizire kuti ali ndi dopamine yokwanira. Mankhwalawa amachititsa izi mwa kumangirira kuzipatala zotanthauza dopamine mu ubongo.
Dopamine agonists imathandizanso kuchepetsa zizindikiro za matenda a Parkinson. Zitha kugwiritsidwa ntchito zokha kapena kuphatikiza ndi L-dopa.
Zotsatira zoyipa za dopamine agonists zimakhala ndi kunyoza, kusanza ndi dontho la magazi. Anthu ena akhoza kukhala ndi makhalidwe opanikizika, omwe amatha kugwiritsa ntchito mankhwalawa, omwe angachepetse ntchito yawo.
Ma-B-Inhibitors
Monoamine oxidase inhibitors - omwe amadziwika kuti MAO-B inhibitors - poyamba amagwiritsidwa ntchito monga chithandizo cha kuvutika maganizo, komanso amathandiza pochiza matenda a Parkinson. Mankhwalawa amachititsa kuti thupi lanu liwonongeke m'mitsempha yanu, zomwe zimathandiza kuti dopamine ndipamwamba komanso kuchepetsa zizindikiro za Parkinson.
Mavitamini a MAO-B omwe amagwiritsidwa ntchito nthawi zambiri ku Parkinson akuphatikizapo Eldepryl ndi Zelapar (selegiline) ndi Azilect (rasagiline). Amatha kuuzidwa yekha kapena ndi mankhwala ena a Parkinson, ndipo zotsatira zake zingakhale monga kunyoza, kupweteka mutu, pakamwa, ulesi, kusowa tulo komanso kusowa chakudya.
Ochita kafukufuku ayang'ana ngati ma-B-inhibitors angathe kuchepetsa kukula kwa matenda a Parkinson (osati kungolimbikitsa zizindikiro), koma atsimikiza kuti palibe umboni wa zimenezo. Komabe, mankhwalawa amathandiza kuchiza zizindikiro za Parkinson.
Zambiri
Mankhwala Ena
Pali mankhwala ena ambiri omwe amagwiritsidwa ntchito pakufuna kupeza mankhwala oyenera bwino ndi zotsatira zochepa.
Gulu lina la mankhwala lotchedwa COMT inhibitors, mwachitsanzo, lingathandize kwambiri L-dopa kufika ku ubongo poletsa thupi kuti lisawonongeke. Comtan (entacapone) ndi Tasmar (tolcapone) ndi zitsanzo ziwiri za COMT inhibitors.
Symmetrel (amantadine) imagwira ntchito poonjezera kuchuluka kwa dopamine yomwe thupi lanu limapanga komanso kuteteza thupi lanu kuti lisamathetse dopamine. Amagwiritsidwa ntchito kumayambiriro a Parkinson kuti athetse zizindikiro, komanso akhoza kuthandizira kuti azipita ku L-dopa.
Anticholinergics monga Cogentin (benztropine) sagwiritsidwa ntchito kawirikawiri koma ingathandize odwala ena aang'ono a Parkinson kuti athetse mantha. Amalowanso khungu lina la ubongo mu ubongo - acetylcholine.
Potsirizira pake, Exelon (rivastigmine), mankhwala osokoneza bongo m'thupi mwa mankhwalawa, amavomerezedwa kuti athetse matenda a dementia ku Parkinson. Zingathandizire kukumbukira kukumbukira kwanu ndi ntchito zanu za tsiku ndi tsiku.