Ngati ndinu mkazi wokhala ndi pang'onopang'ono kapena wamtundu wa hormone thyrotropin (yomwe imatchedwanso kakompyuta yotulutsa hormone , kapena TSH) muli ndi chiopsezo chowonjezereka cha matenda a Alzheimer's . Zomwe anapezazo zinalembedwa m'nyuzipepala ya zamankhwala, Archives of Internal Medicine .
Kafukufuku
Phunziro lalikulu, lopangidwa ngati gawo la Phunziro la Framingham, anthu oposa 2,000 ankayesedwa nthawi zonse kuti azimvetsa matenda a maganizo chifukwa cha nthawi yomwe yakhalapo zaka zoposa khumi.
Gululo linakumananso ndi zaka pafupifupi 13. Pa nthawi yotsatirayi, odwala 209 anaphunzira matenda a Alzheimer's. Mwa amayi, ma level TSH anali okhudzana kwambiri ndi matenda a Alzheimer's. Ndipotu, kwa amayi omwe ali ndi chiwerengero cha TSH m'munsimu 1.0 kapena kuposa 2.1, chiopsezo chachikulu cha matenda a Alzheimer. Chodabwitsa, palibe ubale wofanana womwe unawoneka mwa amuna.
Ofufuza sakudziwa ngati kusintha kwa chithokomiro kumagwira ntchito ndipo TSH ikuchitika musanayambe kapena pambuyo poyambira ndi matenda a Alzheimer's disease. Iwo samadziwanso njira zamasayansi kapena zamoyo zomwe zimayambitsa chibwenzicho. Iwo amachita, komabe, akupempha kuti kufufuza kwina kuchitidwe kuti mudziwe ngati pali zotsatira zina za mankhwala kapena kupewa.
Mwina chinthu chofunikira kwambiri chinali chakuti zotsatira zake zinali zofanana, kaya odwala anali ndi matenda a chithokomiro komanso amatenga mankhwala a chithokomiro m'malo mwake kapena ayi.
Chochita chowonekera chikuwonekera kuti ndi TSH mlingo.
Ngakhale kuyeza kwa hyperthyroidism kapena hypothyroidism kungayambitse mavuto amalingaliro, ndipo mavuto ndi kukumbukira, kulingalira, ndi kuphunzira, zizindikirozi zimaonedwa kukhala zosinthidwa ndi chithandizo choyenera cha chithokomiro. Komabe, phunziroli, likutsutsana ndi chiphunzitso cha chikhalidwe chakuti mavuto a chithokomiro amachititsa kuti munthu asokonezeke maganizo.
M'malo mwake, kafufuzidwe kafukufuku amasonyeza kuti kusayenerera kwa chithokomiro kumatha kukhala chinthu chothandizira kuopsa kokhala ndi matenda a Alzheimer.
Wolemba mabuku wina, Dr. Zaldy Tan, anauza Medscape kuti:
Zinali zokondweretsa kupeza kuti ziŵerengero zochepa komanso zapamwamba zogwirizanitsidwa ndi matenda a Alzheimer's. Mmene ubongo amayesera kusunga mazira a chithokomiro pafupipafupi angapangire kuti kuti ikhale yogwira ntchito bwino, iyenera kusungidwa mkati mwake kupita pansi kapena pamwambapa si chinthu chabwino.
Sindikudziwa ngati mazinga a TSH akuyambitsa Alzheimer's, kutetezera Alzheimer's, kapena matenda a Alzheimer ndi omwe amakhudza TSH. Phunzirolo linali losaiwalika ndipo silinayambe kulingalira zachilengedwe. Akatswiri amanena kuti kusamalira thupi kungathe kuwonongeka ndi matenda a Alzheimer's, kapena kuti kutentha kwa mahomoni otere kumathandiza kuti munthu adwale matenda a Alzheimer's.
Vuto lina lochititsa chidwi limene olemba mabuku amaphunzira amasonyeza kuti maselo a chithokomiro amachititsa kuti muyambe kugwiritsira ntchito jini wotchedwa amyloid precursor protein (APP), yomwe imathandizira Alzheimer's. Zingatheke kuti kusamvana kwa mahomoni a chithokomiro kungayambitse mavuto ndi malamulo a APP, motero kuwonjezera chiopsezo cha Alzheimer's.
Kuwonjezera kuphunzira mu ubale pakati pa chithokomiro, mazinga a TSH, ndi matenda a Alzheimer's. Kufufuza koteroko kungathe kumapereka zifukwa zomveka kuti gulu lachipatala lidzatenge mtundu wowerengera wa TSH.
Nkhaniyi yatsutsana. Mu 2002, American Association of Clinical Endocrinologists (AACE) inalimbikitsa kuchepetsa kutanthauzira kwa TSH kuchokera ku 0,5 mpaka 5.0 mIU / L, kuwonjezereka kwa 0.3 mpaka 3.0, ndi National Association of Clinical Biochemistry inalimbikitsa ngakhale pamwamba malire a 2.5. Ngakhale kuti madokotala ena ndi okhulupirira ena a m'magulu otchedwa endocrinologist adalimbikitsa zotsutsana, AACE anasiya malangizowo, ndipo ma laboratories ndi madokotala akuyesabe kuyesedwa kwa magazi a chithokomiro malinga ndi zaka 0,5 mpaka 5.0 zosiyana.
Mawu ochokera
Pakalipano, phunziroli likupereka umboni winanso wosonyeza kuti, kwa odwala omwe akulandira chithandizo cha chithokomiro, cholinga cha TSH chiyenera kukhala chimodzimodzi pomwe pa mankhwala ayenera kukhala pakati pa 1.0 mpaka 2.0, pokhapokha ngati pali zinthu zina zomwe zimakhalapo nthawi yomweyo. (Mwachitsanzo, odwala khansa ya chithokomiro amakhalabe ndi mankhwala okhudzana ndi chithokomiro, kuteteza chiwerengero cha TSH kwambiri, kapena nthawi zina kuponderezedwa ku magulu pafupi ndi 0, ngati njira yothetsera khansara yowonongeka.
> Chitsime:
> Tan, Zaldy ndi. al. "Ntchito ya Chithokomiro ndi Kuopsa kwa Matenda a Alzheimer: Phunziro la Framingham." Archives of Internal Medicine , 2008; 168 (14): 1514-1520.