Zingamve zachilendo kuwerenga kuti kachilombo ka HIV kangayambe kukalamba, koma zikuwoneka kuti ndi zoona. Kuwonjezera pamenepo, kukalamba msanga sikungokhala nkhani ya HIV yomwe imayambitsa zizindikiro zambiri zomwe zimapezeka mwa akuluakulu. M'malo mwake, thanzi la anthu omwe ali ndi kachilombo koyambitsa matenda a HIV ndi ofanana ndi omwe alibe anthu omwe ali ndi HIV omwe ali ndi zaka pafupifupi 15.
Zina mwa matenda omwe anthu amadwala nawo ukalamba omwe amachitikirapo makamaka kwa achinyamata omwe ali ndi HIV ndi awa:
- Matenda Ozindikira - HIV ingayambitse mavuto poganiza, kukumbukira, ndi kutayika kwa ubongo.
- Fragble ya Thupi - Anthu omwe ali ndi kachilombo ka HIV ali ndipamwamba kuposa chiwopsezo chachikulu cha matenda a osteoporosis ndi fractures.
- Chiwindi - Matenda a shuga ndi ofala kwambiri kwa anthu omwe ali ndi kachilombo ka HIV, ngakhale kuti sakudziwika kuchuluka kwa izo chifukwa cha matendawa komanso kuchuluka kwa zotsatira za HAART .
- Matenda a Mtima - Chifukwa cha kusintha kwa ma lipid chifukwa cha mankhwala ena a kachilombo ka HIV, anthu omwe ali ndi kachilombo ka HIV ali pangozi yowopsa kwa matenda a mitsempha ndi mavuto ena a mtima.
- Kulephera kwa Impso - Kuopsa kwa impso chifukwa cha matendawa ndi chifukwa cha matendawa komanso kutengeka kwa matenda omwe amakhudza impso - monga hepatitis .
Anthu ambiri omwe ali ndi kachilombo ka HIV ali ndi chimodzi kapena zingapo izi zokhudzana ndi kukalamba msanga - chinthu china chotchedwa polypathology .
Ngakhale kuti polypathology ikuwonetsanso anthu akuluakulu omwe alibe kachilombo ka HIV, zimakhala zaka pafupifupi 15 m'mbuyomo mwa anthu omwe ali ndi kachilombo koyambitsa matenda a Edzi - mwa anthu omwe ali ndi zaka zoposa 40 mmalo mwa zaka zapakati pa zaka zisanu ndi ziwiri.
Kukula msinkhu kumatha kukhala ndi anthu omwe ali ndi kachilombo ka HIV ngati ali ndi mankhwala opatsirana pogonana kapena ayi.
Ndipotu, magulu ena a mankhwala ochepetsa kachilombo ka HIV angathandize kuti zizindikiro zakalamba zisanakwane.
Chifukwa chiyani kachilombo ka HIV kamayambitsa kukalamba?
Pali zifukwa zambiri zomwe zimapangitsa kuti kachilombo ka HIV kakula msanga. Zomwe mwazifufuza kwambiri ndi minochondrial poizoni ndi immunosenescence.
Kuchuluka kwa mankhwala a mitochondrial kumachitika makamaka pogwiritsira ntchito NRTI , koma zikuwoneka kuti zikupezeka ndi odwala kachirombo ka HIV omwe samakhala ndi mankhwalawa.
Mitochondria ndi malo opangira magetsi - amapanga imodzi mwa mankhwala omwe matupi athu amafunika kupitilira. Kwa anthu omwe akudwala mitochondrial poizoni, mafakitalewa amayamba kutseka ndipo sabala zipatso. Minochondrial toxicity yakhala ikugwirizana ndi zizindikiro zambiri za ukalamba msanga, kuphatikizapo mavuto a insulini ndi lipodystrophy .
Matendawa amatanthauza kuchepa kwa chitetezo cha mthupi chomwe chimapezeka ndi msinkhu, koma chomwe chimabwera mofulumira kwa anthu omwe ali ndi HIV. Amayambitsa matenda osokoneza bongo komanso matenda aakulu omwe amatha kukhala ndi thanzi labwino.
Kutentha kwakukulu ndi chizindikiro cha ukalamba akuluakulu omwe alibe kachilombo ka HIV. Komabe, zikuganiziridwa kuti nthawi zonse chitetezo cha mthupi ndi HIV ndi chimodzi mwa zifukwa zomwe zimakhalira ndi kachilombo ka HIV ali wamng'ono.
> Zotsatira:
> Capeau J. Kusakalamba Kwakale Kwambiri ndi Zakale Zakale Zosagwirizana ndi Odwala Amene Ali ndi kachilombo ka HIV: Zoona ndi Zomwe amakhulupirira. Clin Infect Dis. 2011 Dec; 53 (11): 1127-9.
> Chang L, Andres M, Sadino J, Jiang CS, Nakama H, Miller E, Ernst T. Mphamvu ya apolipoprotein E 4 ndi HIV pa kuzindikira ndi ubongo wa mtima: antagonistic pleiotropy ndi ukalamba usanafike msinkhu. Neuroimage. 2011 Oct 15; 58 (4): 1017-27.
> Paik IJ, Kotler DP. Kufala ndi matenda a shuga a matenda a shuga mu matenda opatsirana pogonana. Best Best Clinic Clinic Endocrinol Metab. 2011 Jun; 25 (3): 469-78.
> Maagaard A, Kvale D. Mitochondrial poizoni kwa odwala kachilombo ka HIV pokhapokha ndi pa mankhwala ochepetsa kachilombo ka HIV: njira yopitilirapo kapena yapadera? J Antimicrob Amatha. 2009 Nov; 64 (5): 901-9.
> Rickabaugh TM, Kilpatrick RD, Hultin LE, Hultin PM, Hausner MA, Sugar CA, Althoff KN, Margolick JB, Rinaldo CR, Detels R, Phair J, Effros RB, Jamieson BD. Zomwe zimakhudza kachilombo ka HIV-1 komanso kukalamba pa CD4 T-maselo osadziwika: zowonjezera komanso zosiyana siyana za kuwonongeka. PLoS One. 2011 Jan 26; 6 (1): e16459.