Makangaza , omwe poyamba ankawoneka osasangalatsa, tsopano ndi otchuka kwambiri. Msuzi wa makangaza amapezeka pafupi ndi sitolo iliyonse ku North America.
Koma nkhani ina yofalitsidwa mu magazini ya American Journal of Cardiology ya September 1, 2006, ikusonyeza kuti makangaza angagwirizane ndi mankhwala ofala.
Mnyamata wina wazaka 48 anali kutenga ezetimibe (Zetia®) 10 mg tsiku ndi rosuvastatin (Crestor®) 5 mg tsiku lililonse kwa miyezi 17.
Mankhwalawa onse amagwiritsidwa ntchito pa cholesterol.
Anayamba kumwa madzi a makangaza (200 ml kawiri mlungu uliwonse) ndipo patangotha masabata atatu, anavomera kupsinjika ndi ululu wa ntchafu ndi msinkhu wa serum creatine kinase (138,030 U / L, yachibadwa <200 U / L). Zonsezi ndi zizindikiro za rhabdomyolysis, vuto lalikulu lomwe limayambitsa kusokonezeka kwa minofu ndi kukhoza kufooka kwa impso.
Rosuvastatin ndi mankhwala omwe amatchedwa HMG-CoA reductase inhibitors, kapena 'statins'. Madzi a mphesa amadziwika kuti amachititsa chiopsezo cha myopathy, koma mpaka lero, panalibe kanthu kakang'ono kokhudza ngati makangaza a mapulaneti angapangitse chiopsezo.
Madzi a makangaza ndi madzi a mphesa, onse amadziwika kuti amaletsa cytochrome P450 3A4 mavitamini a m'mimba m'matumbo. Mwa kuletsa mavitaminiwa, mazira angapangitse mankhwala ochuluka a magazi.
Kuphatikizana kwa Mankhwala a Makomamanga
- Antiarrhymics - Amiodarone (Cordarone®), disopyramide (Norpace®), quinidine
- Mafuta a calcium - Felodipine (Plendil®), nicardipine (Cardene®), nifedipine (Procardia®), nimodipine (Nimotop®), nisoldipine (Sular®)
- Statins - Atorvastatin (Lipitor®), lovastatin (Mevacor®), simvastatin (Zocor®)
- Matenda a Immunosuppressants - Cyclosporine (Sandimmune®, Neoral®), tacrolimus (Prograf®)
- Protease inhibitors - Saquinavir (Fortovase®)
Komabe, madzi a makangaza angagwirizanenso ndi mankhwala omwe alibe mndandandawu.
Mankhwalawa ezetimibe ndi rosuvastatin saganiziridwa kuti amathyoledwa ndi cytochrome P450 3A4.
Malingana ndi umboni wochepa wokhudzana ndi momwe mungagwiritsire ntchito mankhwala osokoneza bongo, nkofunika kuti muyankhule ndi dokotala ngati mukumwa mankhwala ndipo mukuganiza kuti mukumwa madzi a makangaza.
Zotsatira:
Hidaka M, Okumura M, Fujita K, Ogikubo T, Yamasaki K, Iwakiri T, Setoguchi N, Arimori K. Zotsatira za madzi a makangaza pa cytochrome ya munthu p450 3A (CYP3A) ndi carbamazepine pharmacokinetics mu makoswe. Mankhwala Osokoneza Bongo ndi Kusokoneza. 33.5 (2005): 644-8.
Kim H, Yoon YJ, Shon JH, Cha IJ, Shin JG, Liu KH. Zotsatira zoletsera za timadziti ta zipatso pa ntchito ya CYP3A. Mankhwala Osokoneza Bongo ndi Kusokoneza. 34.4 (2006): 521-3.
Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis yokhudzana ndi makangaza a madzi a makangaza. Journal ya American Cardiology. 98.5 (2006): 705-6.
Chodziwikiratu: Zomwe zili pa tsambali zimapangidwa pazinthu zophunzitsira zokha ndipo sizilowetsamo malangizo, matenda kapena chithandizo ndi dokotala wololedwa. Sichikutanthauza kubisa zonse zomwe zingatheke, kuyanjana kwa mankhwala, zochitika kapena zotsatirapo zoipa. Muyenera kupeza chithandizo chamankhwala mwamsanga pa nkhani iliyonse yathanzi ndikufunsani dokotala musanagwiritse ntchito mankhwala osakaniza kapena kusintha kwa regimen yanu.