Kulumikizana kwa Estrogen
Kodi mukudziwa kuti kukhala ndi migraine kungachepetse chiopsezo cha khansa ya m'mawere m'tsogolo?
Ngakhale kuti khansa ya m'mawere ndi khansa ndizosiyana kwambiri ndi zachipatala, pali chinthu chimodzi chachikulu chomwe chimagwirizanitsa kapena kugwirizanitsa - homoni, estrogen.
Khansa ya m'mawere ndi Estrogen
Khansara ya m'mimba imachitika pamene maselo a khansa osinthika amakula mosalekeza, kawirikawiri mumakhala ndi mapepala a m'mawere.
Kukhala ndi moyo wochulukirapo kwambiri kwa estrogen kumapangitsa chiopsezo chanu cha khansa ya m'mawere. Choncho chilichonse chomwe chimapangitsa estrogen mu thupi ikhoza kuwonjezera chiopsezo cha khansa ya m'mawere. Zitsanzo za zinthu zomwe zimawonjezera estrogen ndizo:
- Chiwerengero cha moyo wautali wa kusamba (kusamba msinkhu usanafike zaka 12, kusamba kwa mimba pambuyo pa zaka 55)
- Manenepausinal obesity, pamene mankhwala a mafuta kapena mafuta amawatembenukira ku estrogen
- Kuphatikiza Mankhwala a Hormone
Migraines ndi Estrogen
Zochitika za migraine zimasiyanasiyana ndi amayi chifukwa cha msambo wawo, boma lawo lachimuna, komanso ngati ali ndi mimba. Kusintha kumeneku mufupipafupi komanso kuuma kwachilendo kumagwirizanitsa ndi mayendedwe a mkazi wa estrogen.
Mwachitsanzo, mafupipafupi a migraine amawonjezeka nthawi isanayambe kapena pamene amayi amayamba kusamba ( kumapeto kwa msambo ), pamene majeremusi ake amayamba kuchepa. Komabe, amayi ambiri amapeza mpumulo wa migraines pa nthawi yachiwiri ndi itatu ya mimba, boma lalikulu la estrojeni.
Migraines ndi Khansa ya M'bwere: A Controversial Connection
Mitsempha yonse ya khansa ndi khansa ya m'mawere ndi estrogen yomwe imayanjanitsidwa, kotero pakhoza kukhala mgwirizano pakati pa zochitika za migraine ndi chiopsezo chochepa cha khansa ya m'mawere. Chimodzi mwa maphunziro oyambirira kuti aunike chiyanjano ichi chinali ku Cancer Epidemiology, Biomarkers ndi Prevention.
Kafukufukuyu anapeza kuti amayi omwe amadziwika kuti ndi migraines anali ndi 33 peresenti yotseketsa ngozi yotenga matenda otchedwa hormone-receptor invasive ductal ndi lobular carcinoma m'mayiko omwe akuwombera anthu. Komabe, phunziroli silinathetsere ntchito ya NSAID , kalasi yamba ya mankhwala ogwiritsira ntchito migraines - ndipo kafukufuku wina wanena kuti ntchito ya NSAID ikhoza kukhala ndi vuto la khansa ya m'munsi.
Kafukufuku wina m'magazini ya Journal of Clinical Oncology anapeza kuti amayi omwe amatha kudzipha okhaokha omwe amadziwika kuti ali ndi migraine, amakhala ndi chiopsezo chochepa cha khansa ya m'mawere. Kafukufukuyu anapeza kuti 17 peresenti yaing'ono yaikala ya khansa yabwino ya hormone-receptor. Kuwonjezera apo, chiopsezo choterechi chinali chopanda ntchito ya NSAID, komanso kugwiritsa ntchito mowa ndi caffeine, awiri omwe amachititsa kuti migraine ayambe kuyambitsa .
Mu 2014, kafukufuku wina ku Cancer Causes and Control anafufuza zoposa 700 za khansa ya m'mawere. Ofufuzawa anapeza kuti poyerekeza ndi amayi omwe alibe mbiri ya migraines, amayi omwe anali ndi mbiri yakale ya migraines (zaka zopitirira 30) anali ndi 60 peresenti yochepa yochepetsera khansa ya m'mawere yotchedwa estrogen receptor.
Kuphatikiza apo, amayi omwe anali ndi migraine yawo yoyamba asanakwanitse zaka 20 anali ndi mwayi wopeza khansa ya m'mawere yotchedwa estrogen (onse opatsirana ndi lobular) poyerekezera ndi osagwira ntchito (akazi).
Pomalizira pake, amayi omwe ali ndi migraine omwe ali ndi aura anali ochepa (pafupifupi theka) kuti adziwe kansa ya m'mawere yotchedwa estrogen (yotchedwa ductal and lobular).
Pazomwe maphunziro a 2013 a Causcer Causes and Control oposa 7,000 ogwidwa ndi migraineurs sanapeze mgwirizano wapakati pakati pa migraines ndi chiopsezo cha khansa ya m'mawere.
Zoonadi, maphunziro onsewa ali ndi malire, ndipo ngati osankhidwa akhoza kufotokoza zotsatira zawo zosiyana. Chithunzi chachikulu apa ndi chakuti ubale umenewu ndi wokondweretsa uyenera kuyang'anitsitsa.
Mfundo Yofunika Kwambiri
Kumbukirani, kulumikizana kumatanthauzira kukhala ndi chiyanjano kapena gulu.
Sichikutanthauza kuti matenda amodzi amachititsa kapena kulepheretsa wina. Kupitiliza maphunziro owonjezereka kumafunika kuyang'ana mgwirizano wovuta pakati pa khansa ya m'mawere ndi migraines.
Kodi Zimenezi Zikutanthauza Chiyani kwa Ine?
Pitirizani kukhalabe othandizira muzamasamalidwe anu. Kambiranani za chiopsezo cha khansa ya m'mawere ndi dokotala wanu. Onaninso momwe moyo wathanzi, monga kulemera kwa thupi, ungachepetsere migraine kuvutika kuwonjezera pa chiopsezo cha khansa ya m'mawere.
Zotsatira:
Dumitrescu R, Cotarla I. Kumvetsetsa chiopsezo cha khansa ya m'mawere: tili pati mu 2005? J Cell Mol Med 2005; 9: 208-21
Harris RE, Chlebowski RT, Jackson RD, et al. Khansara ya m'mimba ndi mankhwala osagwiritsidwa ntchito poletsa kutupa: zotsatira zochokera ku Women's Health Initiative. Cancer Res 2003; 63: 6096-101.
Li CI, Mathes RW, Bluhm EC, Caan B, Cavanagh MF, Chlebowski RT. Mbiri ya Migraine ndi vuto la khansa ya m'mawere pakati pa amayi amantha. J Clin Oncol . 2010 Feb 20; 28 (6): 1005-10.
Mathes RW ndi al. Migraine m'mayi omwe amatha kutuluka m'mbuyo komanso kuopsa kwa khansa ya m'mawere. Kansa Epidemiol Biomarkers Poyamba . 2008 17: 3116-3122.
Zima Zimazizira, Rexrode KM, Lee IM, Buring JE, Tamimi RM, Kurth T. Migraine ndi chiopsezo chotere cha khansa ya m'mawere: omwe amayembekezera kuti aphunzire. Khansa Imayambitsa Kulamulira . 2013 Jan; 24 (1): 81-9.