Niacin (nicotinic acid) ndi mankhwala otsika kwa mafuta m'thupi omwe angakhudze mbali zonse za mbiri yanu , makamaka , kafukufuku wasonyeza kuti nicotinic acid ikhoza:
- Kuwonjezera ma level HDL ndi 25%
- Cholesitala cha Lower LDL chafika 35%
- Lower triglycerides ndi 50%
Ngakhale kuti mungathe kupeza mankhwala osokoneza bongo (nicotinic acid) mwa mankhwala, palinso mitundu ina ya niacin yomwe imapezeka popanda mankhwala ndipo ndi yotchipa.
Ngakhale kuti nyakayi sangafune kuyendera wothandizira zaumoyo wanu mankhwala, izi sizikutanthauza kuti ndizotetezeka kuti mutenge. Phunziro laposachedwapa, lalikulu (phunziro la AIM-HIGH) linawulula kuti anthu omwe ali ndi matenda a mtima atulukira mawindo ambiri a HDL - koma sanawone kuchepetsa chiopsezo chawo chokhala ndi zochitika pamtima - monga matenda a stroke kapena matenda a mtima - kapena imfa. Ndipotu, panalibe kusiyana pakati pa anthu omwe ali mu phunziroli kutenga statin ndi niacin komanso kutenga statin okha. Kuonjezera apo, anthu omwe amatenga nicotinic acid mu phunziro ili anali ndi chiwerengero chokwanira cha zikwapu za ischemic. Chifukwa chakuti palibe kusintha kwa chiopsezo cha imfa kapena zovuta za matenda a mtima ndi nkhawa chifukwa cha kukwapulika kwa ischemic, ofufuzawo anaimitsa phunziroli mofulumira.
Zotsatira zofanana zomwe zimachitika ndi nthenda zimaphatikizanso khungu, kuthamanga, kutentha, komanso kutsekemera mtima.
Komabe, zotsatira zina zoopsa zikhoza kuchitika, ndipo zikhoza kuwonjezeka ngati muli ndi chimodzi mwazifukwa zotsatirazi:
- Gout - Niacin ikhoza kuwonjezera ma asidi a uric acid, kuonjezera mwayi wanu wovutikira.
- Matenda a shuga - Odwala matenda a shuga akutenga nthenda akhoza kuzindikira kuwonjezeka kwa msangamsanga wa shuga wa magazi.
- Matenda a ululu wa Peptic - Maphunziro owona kugwiritsa ntchito kutulutsidwa kwa nicotinic acid ali ndi mbiri ya kukula kwa chilonda cha zilonda. Njira yomwe izi zimapezeka sizidziwika.
- Matenda a chiwindi - Kutenga uchi kumayambitsa kuchuluka kwa michere ya chiwindi, yomwe ingakhale yowonjezereka kwambiri kwa anthu omwe amapezeka kale ndi matenda a chiwindi.
- Matenda a Impso - Kukhala ndi ntchito ya impso yovuta kungachititse kuti niacin iwonjezeke m'magazi anu, mwinamwake poizoni.
- Mimba - Sipanakhalepo maphunziro okwanira kuti aone bwinobwino za chitetezo cha mwana wamwamuna. Choncho, mufunsane ndi wothandizira zaumoyo wanu ngati muli ndi pakati, kapena mukukonzekera kutenga pakati.
- Kudyetsa mawere - Maphunziro awonetsa kuti niacin imatulutsidwa mu mkaka wa m'mawere, komabe, sidziwika bwino ngati mankhwala operekedwa kwa kuchepetsa cholesterol akhoza kuvulaza mwanayo.
- Matenda a m'mtima - Kutenga uchi kumatha kuwononga mavuto ena a mtima, monga angina wosakhazikika.
- Kusokoneza bongo - Kutenga mankhwala a niacin kungachepetse luso lanu lakutseka - ndikulitsa luso lanu lokhala ndi magazi. Izi zingachitenso ngati mutenga antiticoagulants, kapena "ochepa magazi", monga Coumadin (warfarin) kapena aspirin.
Mufukufuku, anthu ena omwe amatenga nkikoni amaletsa kuchepa kwa mlingo kapena zinachititsa kuti asikali asiye chifukwa cha zotsatira.
Chifukwa cha zotsatira zoyipa komanso zosapindulitsa pa umoyo wa mtima, niacin sichivomerezedwa ngati mankhwala oti mutenge ngati mukufuna kuchepetsa chiwerengero cha lipid. Niacin amatha kuganiziridwa ndi wothandizira zaumoyo wanu ngati simungathe kulamulira bwino mankhwala anu ndi mankhwala ena - monga kutenga statin yokha kapena kuphatikizapo statin ndi ezetimibe.
Kotero, ngati mukuyang'ana kuti mukhale ndi niacin muzomwe mukutsitsa, muuzeni wothandizira zaumoyo wanu poyamba. Angakhale ndi njira zinanso zochepetsera chitetezo chanu cha kolesterol ndi triglyceride, ndipo amatha kuganizira ngati mankhwala ena sakugwira ntchito.
Zotsatira:
Micromedex 2.0. Truven Health Analytics, Inc. Greenwood Village, CO. Kupezeka pa: http://www.micromedexsolutions.com. Inapezeka pa February 10, 2016
Dipiro JT, Talbert RL. Pharmacotherapy: Njira ya Pathophysiological, 9th, 2014.
Ofufuza AIM-HIGH. Niacin kwa odwala omwe ali ndi matenda otsika a HDL a cholesterol komanso kulandira chithandizo chamankhwala champhamvu. N Eng J Med 2011; 365: 2255-2267.
Stone NJ et al. 2013 ACC / AHA Malangizo othandizira kuti magazi azisamalidwa ndi magazi ambiri. Circulation 2014; Kuyendayenda 129 (Suppl 2): S1-45