Mankhwalawa akhala ndi zotsatira zosiyana ndipo tsopano akuletsedwa ku Ulaya
Akatswiri ofufuza anafufuza Diacerein kuti aone ngati mankhwalawa amachepetsa kukula kwa matenda a osteoarthritis. Mankhwala osokoneza bongo amadziwika kuti amatha kuchiza matenda a nyamakazi komanso matenda ena a kutupa nyamakazi. Koma mankhwala omwe angasinthe kupitirira kwa matenda a osteoarthritis , kuchepetsana kuwonongeka kwa mgwirizano ndi kuchepetsa mwayi waumphawi, sungakhale wosatsutsika.
Mwamwayi, Diacerein sakanasonyezeranso kuti zoopsa zimaposa ubwino wake, ndipo mankhwala omwe amachititsa osteoarthritis sanalepheretse matendawa.
Zochitika Zachilendo Musamachepetse Matenda Opitirira
Mankhwala osagwiritsa ntchito mankhwala osokoneza bongo chifukwa cha mafupa a m'magazi ndi hip osteoarthritis , ziwalo ziwiri zomwe zimakhudzidwa ndi osteoarthritis, zimaphatikizapo kulemera kwa thupi, kuchita masewera olimbitsa thupi, ndi kupeŵa ntchito zolemetsa zomwe zimapangitsa kuti thupi likhale lopsinjika.
Mankhwalawa ndi mankhwala opatsirana amachiritsira amagwiritsa ntchito mavitamini D okwanira; analgesics monga Tylenol ; NSAIDs (antisteroidal anti-inflammatory drugs) monga naproxen ndi ibuprofen; amathandizira monga glucosamine sulfate ; ndi jekeseni zamagulu . Njira zina zochiritsira ndizo mwa njira zomwe anthu ambiri amachiritsira. Zina osati kuperewera kwa thupi, palibe umboni wosatsimikizirika wakuti mankhwalawa amachepetsa kapena amaletsa osteoarthritis.
Maphunziro a Diacerein monga Osteoarthritis Disease-Modifier
Kafukufuku asanthula kuti angathe kugwiritsa ntchito diacerein kuti athetse matenda a mitsempha ya maondo ndi chiuno. Diacerein ndi mankhwala odana ndi kutupa omwe amagwira ntchito mosiyana ndi NSAIDS. Diacerein imaletsa interleukin-1, mosiyana ndi kulepheretsa njira ya cyclooxygenase (COX) monga NSAIDs.
Mu maphunziro, odwala amalandira kalata ya 50 mg ya dialerein kawiri patsiku. Mu 2006, Cochrane Collaboration inafotokoza ndondomeko zisanu ndi ziwiri zachipatala chomwe chinaphatikizapo diacerein omwe anaphatikiza odwala 2,069. Izi zinamveka kuti diacerein inali ndi zotsatira zochepa zochepetsera ululu ndi kuchepetsa kupitirira kwa matenda a osteoarthritis poyerekeza ndi chithandizo choyenera ndi NSAIDs kapena placebo. Zotsatira zofala kwambiri zogwirizana ndi diacerein ndi kutsekula m'mimba.
Kugwirizana kwa Cochrane kunasinthira ndondomeko yawo yowonongeka mu 2013, kuwonjezera mayesero atatu atsopano a anthu okwana 141. Kafukufuku watsopanowo anatsimikizira kuti mphamvu ya umboni kwa zotsatira za diacerein inali yochepa, ndipo kuchepetsa kupweteka kunali kochepa. M'magulu a mitsempha ya m'chiuno, pangakhale phindu lapang'ono lochepetsera dera lophatikizana, koma mwina sizinali zofunikira kuchipatala. Pali chiopsezo cha makumi awiri ndi awiri (24) chakutsekula m'mimba chifukwa cha diacerein.
European Medicines Agency Imapereka Zoletsa
Pa March 19, 2014, Gulu Lothandizira Kuvomereza Mgwirizano ndi Njira Zowonongeka - Anthu (CMDh) oletsedwa diacerein mu European Union. Chigamulocho chinakhazikika pa September 4, 2014. Gululi linapanga chiganizo chake pangozi ya odwala omwe amakhala ndi matenda otsegula m'mimba komanso matenda a chiwindi chifukwa cha mankhwala.
Mwachidule, gululo linaganiza kuti zoopsa za diacerein zikhoza kupindulitsa kwambiri.
Kodi Palifukufuku Wambiri Wokhudza Diacerein Wofunika?
Katswiri wa chifuwachi, Dr. Scott J. Zashin, anakambirana za diacerein ngati mankhwala othetsera osteoarthritis. "Panthawiyi, palibe umboni wosatsutsika wakuti diacerein imabweretsa zotsatira zabwino monga mankhwala osinthira matenda a osteoarthritis," adatero. "Phunziro lina likufunika kuti pakhale chitetezo chachidule komanso chokhazikika cha diacerein cha osteoarthritis."
Mankhwalawa sapezeka ku United States, European Union, Canada, Britain, kapena Australia. Zitha kukhalapo m'mayiko osankhidwa, malinga ndi malamulo ena.
Chigamulo cha 2014 cha European Union choletsa mankhwalawa chimasonyeza kuti zotsatira zowonongeka za mankhwalawa ndizovuta kwambiri kuposa ubwino wake uliwonse.
Zotsatira:
Fidelix TS, Soares BG, Trevisani VF. "Diacerein wa osteoarthritis." Cochrane Database Rev Rev. 2006 Jan 25; (1): CD005117.
Fidelix TS, Makedoniya CR, Maxwell LJ, Fernandes Moça Trevisani V. "Diacerein wa osteoarthritis." Cochrane Database Rev. 2014 Feb 10; 2: CD005117. lembani: 10.1002 / 14651858.CD005117.pub3.