Daliresp kapena Roflumilast kwa COPD

Zisonyezo, Mapindu ndi Zotsatira Zotsatira za Chithandizo

Phosphodiesterase-4-inhibitors (PDE4) monga Daliresp (roflumilast) ndi gulu latsopano la mankhwala odwala matenda osapatsirana (COPD ) ndi matenda ena a m'mapapo. Mankhwalawa amathandiza kuchepetsa kutupa mumlengalenga kwa anthu omwe sagwirizana ndi mankhwala oyenera. Daliresp (roflumilast) ndiye yekha PDE4 inhibitor amavomerezedwa ku United States.

Kodi Phosphodiesterase-4-Inhibitors Amagwira Ntchito Bwanji?

Mankhwala monga Daliresp ntchito poteteza zotsatira za phosphodiesterase 4, mavitamini omwe amachititsa kuti awononge molekyu yotchedwa cyclic adenosine monophosphate (cAMP.) Kuwonjezeka kochuluka mumsampha (chifukwa sikunasokonezedwe ndi phosphodiesterase 4) kumachepetsa kutupa mu mapapo pakati pa zinthu zina.

Chizindikiro cha COPD ndi kutupa kosatha, ndipo anthu omwe ali ndi COPD ndi mphumu kawirikawiri amakhala ndi pulojekiti yowonjezera ya PDE4 yomwe imapereka ku kuvuta kumeneku.

Pochepa kutupa, mankhwala monga Daliresp angachepetse chiwerengero cha COPD, komanso kuchepetsa kuyendetsa ndege.

Kodi PDE4 Zimatani?

Powonjezera kuchuluka kwa cAMP ndi kuchepa kutentha, PDE4 inhibitors ikhoza kuchepetsa kuchuluka kwa kuchuluka kwa COPD ndikukwaniritsa ntchito ya mapapo. Kupyolera mu kampani yowonjezera, ingayambitsenso matenda ena.

Ndikofunika kuzindikira kuti mankhwalawa samakonza mapapu, amathandiza kuchepa kutupa ndikupewa kuwonongeka komanso kuwonjezereka kwa zizindikiro.

Zinthu Pamene Daliresp (Roflumilast) Angagwiritsidwe Ntchito

Zinthu zomwe Daliresp angagwiritsidwe ntchito ndizo:

• COPD
• Phumu
• Psoriasis
• Psoriatic nyamakazi

Kodi Zimagwiritsidwa Ntchito Piti?

PDE4 inhibitors monga Daliresp amagwiritsidwa ntchito pokonza mapapu ntchito kwa anthu okhala ndi COPD omwe sagwirizana ndi mankhwala oyenera.

Ndi COPD amawoneka kuti ndi opindulitsa kwambiri kwa anthu omwe ali ndi matenda a bronchitis omwe akudwala nthawi zambiri .

Popeza mankhwalawa amagwiritsa ntchito kutukusira kosatha, sagwiritsidwa ntchito povutitsa kwambiri COPD kapena mphumu, koma m'malo mochizira matendawa.

Mosiyana ndi mankhwala opanga opaleshoni, Daliresp ndi mankhwala amodzi a tsiku ndi tsiku, omwe amapezeka kuti apangitse mapapu kugwira ntchito kwa odwala opatsidwa ndi salmeterol ndi Spiriva (tiotropium.)

Zotsatira za PDE4 inhibitors zikuwoneka kukhala zowonjezera ndi corticosteroids.

Zotsatira Zotsatira

Zotsatira zoyipa za PDE4 zowononga zimakhala ndi kutsegula m'mimba, kupweteka, ndi mutu. Zingayambitse kulemera, kotero kulemera kuyenera kuyang'aniridwa pamene akuchiritsidwa ndipo kwachititsa anthu ena kukhala ndi zizindikiro za maganizo.

Kuyanjana

Chifukwa cha kagayidwe kake ka cytochrome P-450, PDE4 inhibitors amatha kusokoneza (kuwonjezeka kapena kuchepa) mankhwala ena amathanso kugwiritsidwa ntchito motere, mwachitsanzo, mankhwala monga erythromycin, cimetidine, mapiritsi oletsa kubereka, mankhwala ena opatsirana, ndi zina zambiri.

Komanso: PDE4, kusankha phosphodiesterase-4 inhibitors

_Zotsatira:

_{Ferguson, G., ndi B. Pangani. Kusamalira matenda olepheretsa kupopa mankhwala. Zaposachedwa. Kusinthidwa 01/21/16.}

_{Mulhall, A., Droege, C., Ernst, N., Panos, R., ndi M. Zafar. Phosphodiesterase 4 inhibitors pofuna kuchiza matenda osokoneza bongo: kubwereza zamakono komanso zopanga mankhwala. Malingaliro a Akatswiri pa Mankhwala Osokoneza Bongo . 2015. 24 (12): 1597-611.}

_{Reid, D., ndi N. Pham. Roflumilast: mankhwala atsopano odwala matenda osokoneza bongo. Annals wa Pharmacotherapy. 2012. 46 (4): 521-9.}

_{Laibulale ya National National Medicine. MedlinePlus. Roflumilast. Kusinthidwa 08/15/12. https://www.nlm.nih.gov/medlineplus/druginfo/meds/a611034.html}