Compazine, Thorazine, ndi Reglan for Attraps Migraine ndi Nausea
Oposa theka la anthu amayamba kusokonezeka ndi kusanza panthawi ya migraine. Popeza kuti dopamine ya neurotransmitter yakhala ikuyambitsa mkaka wambiri pamtundu wa migraine, mankhwala omwe amaletsa dopamine receptors (otchedwa dopamine antagonists) amathandiza kuchepetsa kunyowa ndi kusanza. N'zochititsa chidwi kuti mankhwalawa amachepetsanso kupweteka kwa migraine, choncho nthawi zambiri amagwiritsidwa ntchito ngati mankhwala okhawo pochiza matenda aakulu a migraine.
Compazine mu Migraine Treatment
Antipsychotics ngati Compazine (prochlorperazine) amagwiritsidwa ntchito kwambiri pofuna kuthana ndi migraines yoopsa ndi yogwirizana ndi matendawa.
Kuwonjezera pa kuthana ndi mseru ndi kusanza kwakukulu, Compazine imagwiritsidwanso ntchito pochiza schizophrenia ndi chithandizo cham'mafupipafupi cha chisokonezo chomwe sichikhala ndi maganizo. Compazine imapezeka ngati mapiritsi, capsules otulutsidwa-osungunuka, mawonekedwe a pamlomo, suppositories ndi mbale - zomwe zimaperekedwa mkati mwa mitsempha (kupyolera mu mitsempha) kapena mkati mwa mitsempha. Chifukwa cha vuto la mankhwala opatsirana ndi mankhwala osokoneza bongo, kuphatikizapo kuchepa, Compazine amaperekedwa mwakachetechete kapena mwakachetechete popereka chithandizo cha matenda - kawirikawiri m'chipinda chodzidzimutsa, kuchipatala mwamsanga, kapena kuchipatala.
Zotsatira zowopsa za Compazine ndi kugona, chizunguliro, masomphenya osowa, khungu, kutsika kwa magazi, ndi kutulutsa magazi. Zotsatira za extrapyramidal zingakhalenso ngati minofu ya minofu, kupumula, parkinsonism , kapena tardive dyskinesia.
Chosavuta koma chomwe chingathe kupha moyo kwa Compazine (ndi zina zoteteza antipsychotics) ndi Neuroleptic Malignant syndrome, zomwe zimayambitsa zizindikiro zosiyanasiyana kuphatikizapo malungo, kuthamanga kwa minofu, ndi chisokonezo.
Thorazine mu Migraine Treatment
Thorazine (chlorpromazine) ndi antipsychotic ina yomwe nthawi zina amagwiritsidwa ntchito pochizira migraines yovuta komanso yogwirizana ndi kusanza ndi kusanza.
Mofanana ndi Compazine, kawirikawiri amaperekedwa mwachangu kapena mwachangu pofuna kuthandizira migraine ndi mseru. Malinga ndi kafukufuku wa 2013 mu Journal of Emergency Medicine , Thorazine adapangitsa ululu kupweteka kwa mutu, kupwetekedwa mtima, komanso kukhudzidwa kuti anthu azikhala ndi migraine poyerekeza ndi anthu omwe amatenga placebo (saline infusion). Koma mu phunziro ili, anthu ambiri adayamba kugona ndi chizungulire poyimirira akamatenga Thorazine, poyerekezera ndi anthu omwe analandira malowa.
Reglan mu Chithandizo cha Migraine
Reglan (metoclopramide) imathandizenso kuchepetsa dopamine receptors. Koma mosiyana ndi ena antipsychotics, amagwiritsidwa ntchito kuwonjezera chapamimba motility kwa anthu omwe ali ndi vuto kuthetsa mimba zawo, monga anthu omwe ali ndi shuga. Mofanana ndi Compazine, Reglan amagwiritsidwanso ntchito pochiza nsomba ndi kusanza, makamaka m'chipinda chodzidzimutsa kapena pamalo ochezera mwamsanga, ndipo ndizothandiza kwambiri. Ndipotu, kafukufuku wina wa chaka cha 2013 wa Cochrane anapeza kuti reglan ndi aspirin zinathandiza kuti migraine iwonongeke komanso kusanza ndi zotsatira zochepa poyerekeza ndi triptan Imitrex (sumatriptan).
Ngakhale Reglan amakhala ndi zotsatira zochepa kusiyana ndi zotsutsana ndi zina zotere:
- kupuma
- kutopa
- chizungulire
- mutu
- chisokonezo
- mavuto ogona
Monga Compazine ngakhale, zotsatira zoyipa monga zizindikiro za extrapyramidal ndi Neuroleptic Malignant Syndrome zingachitike (zosavuta). Komanso, Reglan akhoza kuonjezera chiopsezo cha munthu kuvutika maganizo ndi kudzipha.
Pansi
Kuchotsa mitsempha ya migraine ndi kusanza, mankhwala omwe amaletsa dopamine receptors mu ubongo (antopamine antagonists) amagwiritsidwa ntchito, makamaka Compazine, Thorazine, kapena Reglan. Ngakhale mankhwalawa ali othandiza kwambiri, amakhala ndi chiopsezo. Onetsetsani kuti adziwe dokotala akukuthandizani chifukwa cha matenda onse ndi mankhwala, kuphatikizapo mavitamini, zakudya zowonjezereka, komanso mankhwala ochiritsira.
Zotsatira:
Bigal ME, Bordini CA & Speciali JG. Intravenous chlorpromazine mu chithandizo chodzidzimutsa chithandizo cha migraines: kuyesedwa kosasinthika. J Emerg Med . 2002 Aug, 23 (2): 141-8.
Flake ZA, Linn BS & Hornecker JR. Kusankhidwa kothandiza kwa antiemetics mu malo oyendetsa. Am Phys Physician 2015 Mar 1; 91 (5): 29306.
Láinez M JA, García-Casado A & Gascón. Kukonzekera bwino kwa mseru ndi kusanza mu migraine: kukulitsa zotsatira za m "modzi. Zotsatira Zachibale Zopirira . 2013; 4: 61-73.
US Food and Drug Administration. Malangizo a mankhwala: Compazine. Inapezeka pa February 4th 2016.
US Food and Drug Administration. Malangizo a Mankhwala: Reglan (metoclopramide jekeseni). Inapezeka pa February 5th 2016.
KUDZIZIRANI: Zomwe zili pa tsamba ili ndi zolinga za maphunziro okha. Sitiyenera kugwiritsidwa ntchito ngati choloweza m'malo mwa chisamaliro cha munthu wodwala wovomerezeka. Chonde funsani dokotala wanu kuti apeze matenda ndi chithandizo cha chilichonse chokhudza zizindikiro kapena matenda .