Avodart ndi Proscar ndi FDA-kuvomerezedwa kuti athandizidwe ndi zotsatira za mkodzo kuchokera kukulitsa kwa prostate . Dzina lachibadwa la Avodart ndi dutasteride; Dzina la enieni la Proscar ndiloperekera ndalama. Mankhwalawa, amakhala ndi ntchito zambiri kuposa kungowonjezera ntchito yamkodzo. Amagwira ntchito poletsa mtundu wa testosterone wotchedwa dihydrotestosterone (DHT) yomwe imayang'ana pa prostate, yomwe imalimbikitsa kuti imere ndikukula.
Pamene DHT yaletsa prostate gland kuchepa, kusintha kukwera kwa mkodzo.
Pali zotsatira zoyipa. Kupanga nyemba kumachepetsedwa. Nthaŵi zina amuna amafotokoza kuchepetsa ku libido ndi potency. Komanso, kutsegulira m'mawere kumatha. Kawirikawiri, zotsatirazi zidzatha kapena kuchepetsa malinga ngati mankhwala atayimitsidwa pa chizindikiro choyamba cha vuto. Kupatula phindu lakodzo, pali mndandanda wautali wazinthu zina zomwe zingathandize.
Avodart kapena Proscar akhoza:
- Lower PSA ndi kuchepetsa chiopsezo chopezeka ndi khansa ya prostate
- Kupititsa patsogolo chiwerengero cha khansa ya prostate yapamwamba kwambiri kwa amuna omwe akudwala matendawa
- Chifukwa Gleason 6 khansa (khansa yapamwamba) kuyambanso kapena kuponderezedwa
- Kuyanjanitsa ndi mankhwala ena ochizira kansa ya prostate monga Casodex kapena Lupron
- Thandizani kukhala ndi amuna nthawi yoyang'anitsitsa ndi kuchepetsa chiopsezo chofunikira opaleshoni kapena ma radiation
- Pewani kumeta tsitsi la amuna
- Kusachedwa kuchepa kwa amuna omwe ali ndi nthawi yowonongeka msanga
Zomwe Zimayambitsa Khansa
Kafukufuku woposerapo poyerekeza ndi Proscar ndi placebo, amuna 10,000 anadwala prostate biopsy patapita zaka zisanu ndi ziwiri za chithandizo. Amuna opatsidwa mankhwala a Proscar anapezeka kuti ali ndi khansa 25% mobwerezabwereza poyerekeza ndi amuna omwe amachitira ndi placebo.
Komabe, changu cha ntchito ya Proscar popewera khansa inachepeka chifukwa kafukufuku womwewo adalemba kuti 1% yowonjezera kudwala kansa ya prostate.
Akatswiri panthawiyo ankaganiza kuti Proscar yowonjezera kuchuluka kwa chiwerengero kusiyana ndi kuyambitsa matenda ambiri. Komabe, Peter Scardino MD, wolemba urologist wotchuka pa Memorial Sloan Kettering anafalitsa lingaliro lakuti Proscar ikhoza kuchititsa khansa yowopsa kwambiri, kukweza mitundu yonse yachisokonezo ndikukakamiza FDA kupereka chenjezo. Zoopsya zonsezi zinathetsedwa mu August 15 th , 2013, magazini ya New England Journal of Medicine yomwe inasonyeza kuti palibe khansa ya prostate yowonjezereka mwa amuna amene anachiritsidwa ndi Proscar poyerekeza ndi amuna omwe anachitidwa ndi placebo pambuyo pa zaka 18.
Kuyambira ntchito ya Avodart ndi Proscar ndi njira yomweyi, zambiri zomwe zimadziwika za Proscar zingathenso kunenedwa za Avodart. Zonsezi zimagwiritsa ntchito 5- alpha-reductase (5-AR), puloteni yomwe imatembenuza testosterone kukhala DHT. Pali mwayi wapadera wa Avodart pa Proscar chifukwa Avodart imateteza mavitamini 5-AR mwangwiro. Palibe mayesero a kachipatala, komabe, achitidwa poyerekeza mutu wothandizira awiriwo kumutu.
Popeza onse a Proscar ndi Avodart otsika PSA pafupifupi 50%, funso limabuka, "Kodi akugwedeza mphamvu ya PSA kuwonetsa kukula kwa khansa?" Mwachidule, yankho ndilo ayi. Mankhwalawa samayimitsa PSA kuti ayambe kukwera ndi amuna omwe ali ndi kansa yopitirira. Komabe, PSA imakhazikitsanso pansi pa 50% pambuyo poyambira Proscar kapena Avodart. Kawirikawiri, munthu yemwe ali ndi PSA wa 6.0 asanayambe Proscar adzagwa mpaka 3.0 mkati mwa miyezi ingapo. Pambuyo pake, ngati PSA ikukwera nthawi zonse pamwamba pa 3.0, kupititsa patsogolo khansa kuyenera kusangalatsidwa ngati chifukwa chotheka.
Proscar ndi Avodart amakhala ndi zotsatira zochepa ndipo pali zochepa ngati zimayenderana ndi mankhwala ena.
Pamene zotsatira zowonongeka zimachitika, zimakhala zosinthika. Proscar ndi Avodart ndizovuta chifukwa zingatengedwe nthawi iliyonse ya tsiku, kapena popanda chakudya. Finasteride, generic kwa Proscar ilipo komanso yotsika mtengo. Ndalama yabwinoyi komanso mafilimu omwe amawonekera pambaliyi zimapangitsa kuti odwala ali ndi kansa ya prostate, omwe amafuna kuti azikhala ndi PSA ndikukhalabe ndi moyo wabwino.