Kodi Zinbryta Zimagwira Ntchito Zotani ndipo Zingatheke Bwanji?
Mu May 2016, United States Chakudya ndi Drug Administration chinavomereza kuti mankhwalawa asinthidwe ndi matenda a Zinbryta (daclizumab) pochiritsa MS .
Zinbryta ndi mankhwala operekedwa pansi pa khungu milungu iwiri iliyonse. Zimakhulupirira kuti zimagwira ntchito potseka tsamba lokhazikika pa interleukin-2 (IL-2) -a molecule mu chitetezo cha mthupi chomwe chimayambitsa T-maselo anu.
Mwa kulepheretsa receptor pa interleukin-2, maselo a T sagwiritsidwa ntchito kuti amenyane ndi chiwalo cha myelin mu ubongo wanu ndi msana.
Zinbyta angagwiritsenso ntchito mwa kuwonjezera maselo m'thupi lomwe limatchedwa maselo achilengedwe, omwe amapha maselo a T omwe amachitidwa kuti aziteteza chigwa cha myelin.
Sayansi ya Zinbryta
Phunziro lalikulu mu The New England Journal of Medicine, anthu okwana 1841 omwe ali ndi MS obwezeretsa kachilomboka adapatsidwa mwayi wokalandira mlingo wa Zinbryta (daclizumab) milungu iwiri iliyonse kapena Avonex (interferon β-1a) mlungu uliwonse kwa zaka pafupifupi zitatu.
Zotsatira zinasonyeza kuti anthu omwe analandira Zinbryta anali ndi 45 peresenti yochepa MS amabwerera chaka chimodzi kuposa omwe adalandira Avonex.
Kuonjezera apo, chiwerengero cha zowononga za MS pa MRI chinali 54 peresenti yochepa mwa iwo omwe analandira daclizumab, poyerekeza ndi omwe anachitidwa ndi Avonex.
Mu phunziro lina ku Lancet , anthu pafupifupi 600 omwe ali ndi MS obwezeretsa kachilombo ka HIV adasinthidwa kuti alandire mlingo wa Zinbryta (150mg), mlingo waukulu wa Zinbryta (300mg), kapena injection ya placebo.
Ophunzirawo kapena ochita kafukufuku sanadziwe kuti jekeseni wapatsidwa-izi zimatchedwa kuphunzira kawiri konse khungu ndipo zimateteza zotsatirazo chifukwa chokhala osakondera. Ophunzira adalandira jekeseni mlungu uliwonse kwa chaka chimodzi.
Zotsatira zimasonyeza kuti poyerekeza ndi placebo, mlingo wazitali wa Zinbryta (150mg) unachepetsanso mphamvu ya MS kubwerera mmbuyo mwa 54 peresenti, ndipo mlingo wapamwamba (300mg) unachepetsa chiwerengero cha MS retlapse ndi 50 peresenti.
Choncho, mlingo wapansi ndi wapamwamba umapereka zotsatira zofanana kwambiri, chifukwa chake mlingo wamunsi umagwiritsidwa ntchito kuchepetsa zotsatira zovulaza.
Zotsatira Zowopsa za Zinbryta
Mofanana ndi mankhwala onse, Zinbryta amakhala ndi zotsatira zoyipa, ena mwina mwina kuopseza moyo. Izi zikutchulidwa ngati chenjezo la boxed ndipo zikuphatikizapo:
- Kuvulala kwakukulu kwa chiwindi chomwe chingakhale chakupha
- kutupa koloni
- zochita za khungu
- Zilonda zamakono zimakula
Zochenjeza zina za mankhwala zimaphatikizapo zomwe zingayambitse vutoli, komanso chiopsezo chowonjezereka chokhala ndi matenda ndi kuvutika maganizo, kuphatikizapo kudzipha.
Malingana ndi zotsatira zomwe zimawopsya, zomwe zimafotokozedwa pa phunziroli zikuyerekezera Zinbryta ndi Avonex ndizo:
- zizindikiro zozizira
- kutentha kwapakati pamatenda kapena bronchitis
- chizungu, kuthamanga, kapena khungu lina
- chimfine
- ululu wa mmero
- Zilonda zamakono
Zina zomwe zimawoneka kuti zowonongeka zimaphatikizapo kuwuka kwa chiwindi ndi chipsinjo.
Chifukwa cha zotsatira zowonongeka izi, Zinbryta ikulimbikitsidwa kwa anthu omwe ali ndi MS omwe sanayankhepo kuchipatala cha MS kapena awiri.
Kuonjezerapo, izo zikhoza kulamulidwa pokhapokha pulogalamu yotchedwa Risk Assessment and Strategic Strategies (REMS). Izi zikutanthauza kuti katswiri wanu wamaganizo ayenera kutsimikiziridwa kuti akuchitireni ndi Zinbryta.
Cholinga cha pulojekiti ndikutsimikizira kuti katswiri wanu wamagetsi akuyang'anirani inu kuti zitha kuwonongeka, monga kuyang'ana nthawi yowona chiwopsezo cha magazi.
Mawu Ochokera
Zimalimbikitsa pamene mankhwala atsopano a MS matenda amavomerezedwa ndi a FDA, ndipo uthenga wabwino ndi wakuti pali zambiri muipiipi. Izi zikunenedwa, mankhwalawa akhoza kapena sangakhale abwino kwa inu.
Pali zambiri zomwe muyenera kuziganizira mukasankha mankhwala a MS ngati matenda anu ena, kaya mutha kutenga mimba posachedwa, ndipo mungathe kukhumudwa ndi zotsatira zake zowonongeka.
Komanso, Zinbryta sangakhale "bwino" kuposa mankhwala omwe muli nawo tsopano a MS matenda. Panali phunziro limodzi lokha loyerekeza ndi Avonex. Tsono ngakhale Zinbryta atachepetsa chiwerengero cha kubwereranso poyerekeza ndi Avonex, sitingathe kuzipanga izi kuchipatala china cha MS.
Zotsatira:
Gold R et al. Daclizumab mkulu-zokolola njira yobwereza-remitting multiple sclerosis (SELECT): mayesero osadziwika, aŵiri osawona, omwe ali ndi ma placebo. Lancet. 2013; 381) 9884): 2167-75.
Kapos L et al. Daclizumab HYP motsutsana ndi Interferon Beta-1a Kubwezeretsanso Matenda a Multiple Sclerosis. N Engl J Med . 2015; 373 (15): 1418-28.
Milo R. Mphamvu ndi chitetezo cha daclizumab ndi zomwe zingathandize pakupiritsa matenda osiyanasiyana. Adv Adv Neurol Disord. 2014; 7 (1): 7-21.
US Food and Drug Administration Kulongosola Zowonjezera. (2016). Zinbryta.