Mayendedwe a Nucleic-acid amplification, omwe amadziwikanso kuti NATs kapena NAATs, amagwiritsidwa ntchito kudziŵitsa DNA kapena RNA yochepa muzoyezetsa mayeso. Pankhani ya kuyezetsa matenda a STD , pali ma NAT omwe alipo omwe amatha kuzindikira mitundu yosiyanasiyana ya matenda opatsirana pogonana. Ndipotu, mayeso ambiri amtundu wa STD amapangidwa pogwiritsa ntchito mayesero amphamvu okhudzidwa ndi nucleic acid.
Kodi Nucleic-Acid Amplification Imayesa Ntchito?
Pali mitundu yambiri ya ma nucleic acid acid amplification test, koma zonsezi zimagwirizana ndi mfundo yomweyo.
NAT imagwiritsa ntchito makina osiyanasiyana mobwerezabwereza kuti apange ma CD ambiri a DNA kapena RNA omwe madokotala akuyesera kuwazindikira. Kuchita izi kumalimbikitsa chizindikiro cha nucleic acid mu test test kuti zikhale zosavuta kuzindikira. Ndizosavuta kupeza makope 10,000 a jini kuposa 10.
Kodi Izi Zili ndi Chiyani Ndi Mayeso a Edzi?
Njira yowonjezera mabakiteriya kapena mavairasi a nucleic siyokha ayi yesero la STD . M'malo mwake, pokhapokha kuchuluka kwa DNA kapena RNA mu chitsanzo pogwiritsira ntchito PCR kapena LCR , mayesero ochiritsira amodzi amagwiritsidwa ntchito kuti azindikire. Mayeserowa nthawi zambiri amakhala ndi mtundu wina wa nucleic acid hybridation. Mu mayeserowa, chitsanzochi chimapangidwa ndi DNA kapena RNA yomwe imapangidwa moyenera yomwe imawunikira mosavuta. Zingakuthandizeni kuzijambula ngati zowala mumdima wakuda womwe umangokhala pa chidziwitso chimodzi chodziwika bwino.
Kuyeza kwa nucleic-acid kukuthandizira kwambiri pa kuyesa kwa STD. Amalola madokotala kuti azindikire tizilombo toyambitsa matenda opatsirana pogonana ngakhale pamene pali zamoyo zochepa kwambiri. Ndi mtundu wa teknoloji umene wapangitsa kuti kuyetsetsa mkodzo kwa matenda opatsirana pogonana omwe poyamba analiwoneka ndi swab.
Komanso, popeza mayeso a nucleic-acid amplification ali ovuta kwambiri ngakhale ngakhale tizilombo toyambitsa matenda a DNA, ndi ofunika kwambiri kuti tiwonetse magazi. Mayeserowa amachititsa kuti athe kupeza kachilombo kakang'ono ka HIV ndi tizilombo toyambitsa matenda omwe mwina sitingathe kutero.
Palinso mayeso osapulidwa a nucleic acid omwe amapezeka kwa matenda ena opatsirana pogonana, monga gonorrhea ndi chlamydia . Mayeso osakanizidwa a nucleic acid ayesetsedwe kuti agwiritsidwe ntchito nthawi zambiri pamene mabakiteriya kapena mavairasi a DNA (kapena RNA) ayenera kuyembekezera kukhalapo, monga chithunzithunzi cha chigololo kapena muchitsanzo cha bakiteriya . Zikatero, palibe kuwonjezeka n'kofunikira. Mu zitsanzo izi, ngati DNA kapena RNA ilipo, iyenera kukhalapo pamtundu woyenera.
Chitsanzo cha mayesero awa pochita
Mayendedwe a nucleic-acid amplification ndi njira zodabwitsa kwambiri zodziwira ngati mabakiteriya kapena kachilombo kamapezeka muzitsanzo zamoyo. Pofika pozindikira tizilombo toyambitsa matenda m'thupi mwa munthu amene ali ndi zizindikiro, mayeserowa amakhala ngati njira yodalirika yotsatira chikhalidwe cha tizilombo . Zikhalidwe zachilombo zingakhale zovuta kwa ma laboratories ena kuti azichita. Mosiyana ndi mayesero a magazi a herpes , NAT imaphatikizapo kutsimikizira kuti kachilombo ka HIV kalipo mu chitsanzo kusiyana ndi kuyang'ana anti-herpes antibodies.
Kukula kwa nucleic-acid kunaloledwanso kuti chitukuko cha chlamydia ndi gonorrhea chisefukire padziko lonse lapansi. Tsopano kuyerekezera kotereku kungathe kuchitidwa pazitsulo zamkodzo mmalo mopempha chikhomo cha mitsempha. Izi zakhala zosavuta kuyesa chiwerengero chachikulu cha abambo ndi abambo ku matenda opatsirana pogonana m'magulu osiyanasiyana ochizira komanso osakaniza. Kusonkhanitsa mkodzo sikungasowe luso la zachipatala, ndipo anthu amatha kukhala okonzeka kuwona chikho kusiyana ndi kugwiritsidwa ntchito pochita chiwerewere.
Ochita kafukufuku agwiritsanso ntchito mayeso a nucleic-acid amplification kuti adziwe zambiri zokhudza kukula kwa vuto la matenda opatsirana pogonana ku United States.
Mapulogalamu akuluakulu owonetseredwa ndi NAT akhala akugwiritsidwa ntchito m'masewera, m'mizinda ya m'midzi, mwa amuna omwe amagonana ndi amuna, komanso m'magulu ena omwe ali pangozi kwambiri. Mayeserowa amalola kupezeka kwa matenda opatsirana pogonana muzitsanzo zazing'ono zomwe nthawi zambiri zimatengedwa ngati mbali ya maphunziro akuluakulu a kafukufuku wathanzi la anthu.
> Zotsatira:
> Bernstein KT, Chow JM, Pathela P, TL ya mphatso. Matenda a Bacterial Sexually Transmitted Screening kunja kwa chipatala - Zotsatira za ndondomeko ya matenda opatsirana pogonana masiku ano. Kugonana Kwadongosolo. 2016 Feb; 43 (2 Suppl 1): S42-52. do: 10.1097 / OLQ.0000000000000343.
> Chow EPF, Walker S, Werengani TRH, Chen WANGA, Bradshaw CS, Fairley CK. Gwiritsani Ntchito Yodzidzimutsa ya Mphungu ndi Pharyngeal Gonorrhea Kuzindikira ndi Nucleic Acid Kupopera Kuyesa. Kugonana Kwadongosolo. 2017 Oct; 44 (10): 593-595. lembani: 10.1097 / OLQ.0000000000000654.
> Trembizki E, Costa AM, Tabrizi SN, Whiley DM, Twin J. Mavuto ndi zovuta za kuyesa maselo kuti apeze tizilombo toyambitsa matenda. Matenda. 2015 Apr; 47 (3): 219-26. onetsani: 10.1097 / PAT.0000000000000239.